BR112015015847A2 - composição farmacêutica sólida ou semi-sólida, forma de dosagem sólida ou semi-sólida, uso de um álcool polialcoxilado e método para aumentar a solubilidade ou a taxa de dissolução de um ingrediente farmacêutico ativo - Google Patents
composição farmacêutica sólida ou semi-sólida, forma de dosagem sólida ou semi-sólida, uso de um álcool polialcoxilado e método para aumentar a solubilidade ou a taxa de dissolução de um ingrediente farmacêutico ativoInfo
- Publication number
- BR112015015847A2 BR112015015847A2 BR112015015847A BR112015015847A BR112015015847A2 BR 112015015847 A2 BR112015015847 A2 BR 112015015847A2 BR 112015015847 A BR112015015847 A BR 112015015847A BR 112015015847 A BR112015015847 A BR 112015015847A BR 112015015847 A2 BR112015015847 A2 BR 112015015847A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid
- semi
- polyalkoxy
- active pharmaceutical
- alcohol
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/16—Cyclic ethers having four or more ring atoms
- C08G65/20—Tetrahydrofuran
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
resumo “composição farmacêutica sólida ou semi-sólida, forma de dosagem sólida ou semi-sólida, uso de um álcool polialcoxilado e método para aumentar a solubilidade ou a taxa de dissolução de um ingrediente farmacêutico ativo” a presente invenção refere-se ao uso de álcoois polialcoxilados da fórmula r-o-(ao)-h, sendo que r é um grupo alquila substituído ou não substituído, alquenila, alquinila, arila, aralquila ou um grupo heterocíclico tendo 7 a 25 átomos de carbono, (ao) é uma parcela de polioxialquileno da composição (bo)m(eo)n(do)r com arranjo aleatório ou um arranjo bloco a bloco (“blockwise”) das unidades de oxialquileno constituintes, onde m, n e r representam o número médio de unidades de oxibutileno (bo), unidades de oxietileno (eo) e unidades de oxialquileno derivadas de pelo menos um epóxido selecionado a partir do óxido de estireno e óxidos de alquileno tendo de 5 a 10 átomos de carbono (do) por molécula do álcool polialcoxilado, respectivamente, m sendo um número maior que ou igual a 1, n sendo um número maior que ou igual a 1 e r sendo um número na faixa de 0 a 50 sob a provisão de que (m+n+r) é menor que ou igual a 200 e a proporção n/(m+r) está na faixa de 1 a 20, como excipientes na composição farmacêutica. dito álcool polialcoxilado capacita uma solubilização muito efetiva de ingredientes farmacêuticos ativos pobremente solúveis em meio aquoso. as composições farmacêuticas sólidas ou semi-sólidas compreendendo um ou mais tais como álcool polialcoxilado combinado com pelo menos um ingrediente farmacêutico ativo sendo adicionalmente estáveis em longos períodos sob condições de armazenamento típicas e podem ser facilmente providos em várias formas de dosagens, tais como tabletes e cápsulas preenchidas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361803478P | 2013-03-20 | 2013-03-20 | |
PCT/US2014/011284 WO2014149160A1 (en) | 2013-03-20 | 2014-01-13 | Polyalkoxylated alcohols as excipients for pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015015847A2 true BR112015015847A2 (pt) | 2017-07-11 |
Family
ID=50023898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015015847A BR112015015847A2 (pt) | 2013-03-20 | 2014-01-13 | composição farmacêutica sólida ou semi-sólida, forma de dosagem sólida ou semi-sólida, uso de um álcool polialcoxilado e método para aumentar a solubilidade ou a taxa de dissolução de um ingrediente farmacêutico ativo |
Country Status (7)
Country | Link |
---|---|
US (1) | US9592294B2 (pt) |
EP (1) | EP2976108B1 (pt) |
JP (1) | JP6027285B2 (pt) |
KR (1) | KR101688852B1 (pt) |
CN (1) | CN105007946B (pt) |
BR (1) | BR112015015847A2 (pt) |
WO (1) | WO2014149160A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3169324B1 (en) | 2014-07-14 | 2019-05-08 | Orion Biotechnology Canada Ltd. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
EP3893846A1 (en) * | 2018-12-11 | 2021-10-20 | Dow Global Technologies LLC | Aqueous solutions of poorly soluble active ingredients using polyalkyoxylated amino alcohols |
BR112021008954A2 (pt) * | 2018-12-11 | 2021-08-10 | Dow Global Technologies Llc | composição, e, método |
BR112021009135A2 (pt) | 2018-12-13 | 2021-08-10 | Dow Global Technologies Llc | formulação de detergente líquido para roupas |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147131A (en) | 1995-11-15 | 2000-11-14 | The Dow Chemical Company | High internal phase emulsions (HIPEs) and foams made therefrom |
DE69904014T2 (de) | 1999-02-19 | 2003-04-30 | Warner-Lambert Co., Morris Plains | Therapeutisch wässerige Zusammensetzung enthaltend ein Hexahydro-5-pyrimidinamine Derivat und einen polyalkoxylierten Fettalkohol |
US6372251B2 (en) | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
DE50003908D1 (de) | 2000-08-04 | 2003-11-06 | W Kolb Ag Hedingen Dr | Tocopherylalkoxylate, deren Herstellung und Verwendung in kosmetischen und pharmazeutischen Formulierungen |
DE10053512A1 (de) | 2000-10-27 | 2002-05-02 | Basf Ag | Verwendung von Terpenalkohol-Ethoxylaten als Solubilisatoren in kosmetischen oder pharmazeutischen Zubereitungen oder Konzentraten für Lebensmittelzubereitungen |
US20020094945A1 (en) * | 2000-12-18 | 2002-07-18 | Gross Stephen F. | Reaction products of alkoxylated compounds and polyepoxides |
EP1401503B1 (en) | 2001-06-22 | 2007-05-09 | Pfizer Products Inc. | Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug and a solubility-enhancing polymer |
CN1280246C (zh) | 2002-04-26 | 2006-10-18 | 巴斯福股份公司 | C10链烷醇烷氧基化物及其应用 |
JP2006188619A (ja) | 2005-01-07 | 2006-07-20 | Ge Toshiba Silicones Co Ltd | 水中油型ポリオルガノシロキサンエマルジョン |
GB0907003D0 (en) | 2009-04-23 | 2009-06-03 | Syngenta Ltd | Formulation |
JP5647143B2 (ja) * | 2009-11-30 | 2014-12-24 | 株式会社 資生堂 | ポリマーソーム及び製造方法 |
EP2377556A1 (de) | 2010-04-14 | 2011-10-19 | Cognis IP Management GmbH | Eine Zusammensetzung |
-
2014
- 2014-01-13 JP JP2016500163A patent/JP6027285B2/ja not_active Expired - Fee Related
- 2014-01-13 EP EP14701660.4A patent/EP2976108B1/en not_active Not-in-force
- 2014-01-13 WO PCT/US2014/011284 patent/WO2014149160A1/en active Application Filing
- 2014-01-13 BR BR112015015847A patent/BR112015015847A2/pt not_active Application Discontinuation
- 2014-01-13 KR KR1020157026834A patent/KR101688852B1/ko active IP Right Grant
- 2014-01-13 US US14/649,721 patent/US9592294B2/en not_active Expired - Fee Related
- 2014-01-13 CN CN201480012459.1A patent/CN105007946B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2976108A1 (en) | 2016-01-27 |
CN105007946B (zh) | 2017-09-29 |
CN105007946A (zh) | 2015-10-28 |
US9592294B2 (en) | 2017-03-14 |
JP6027285B2 (ja) | 2016-11-16 |
JP2016516027A (ja) | 2016-06-02 |
EP2976108B1 (en) | 2018-10-10 |
WO2014149160A1 (en) | 2014-09-25 |
US20150374823A1 (en) | 2015-12-31 |
KR20150119962A (ko) | 2015-10-26 |
KR101688852B1 (ko) | 2016-12-22 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |