BR112015015319A2 - composições de nanopartícula de albumina e paclitaxel - Google Patents
composições de nanopartícula de albumina e paclitaxelInfo
- Publication number
- BR112015015319A2 BR112015015319A2 BR112015015319A BR112015015319A BR112015015319A2 BR 112015015319 A2 BR112015015319 A2 BR 112015015319A2 BR 112015015319 A BR112015015319 A BR 112015015319A BR 112015015319 A BR112015015319 A BR 112015015319A BR 112015015319 A2 BR112015015319 A2 BR 112015015319A2
- Authority
- BR
- Brazil
- Prior art keywords
- albumin
- compositions
- paclitaxel
- nanoparticle compositions
- paclitaxel nanoparticle
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 6
- 108010088751 Albumins Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 6
- 229930012538 Paclitaxel Natural products 0.000 title abstract 4
- 239000002105 nanoparticle Substances 0.000 title abstract 4
- 229960001592 paclitaxel Drugs 0.000 title abstract 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261747123P | 2012-12-28 | 2012-12-28 | |
| US13/794,705 US20140186447A1 (en) | 2012-12-28 | 2013-03-11 | Nanoparticle compositions of albumin and paclitaxel |
| PCT/US2013/076630 WO2014105644A1 (en) | 2012-12-28 | 2013-12-19 | Nanoparticle compositions of albumin and paclitaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015015319A2 true BR112015015319A2 (pt) | 2017-07-11 |
Family
ID=51017455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015015319A BR112015015319A2 (pt) | 2012-12-28 | 2013-12-19 | composições de nanopartícula de albumina e paclitaxel |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20140186447A1 (https=) |
| EP (1) | EP2938340A4 (https=) |
| JP (2) | JP2016504362A (https=) |
| KR (1) | KR20150100903A (https=) |
| CN (1) | CN105007912A (https=) |
| AU (1) | AU2013370955B2 (https=) |
| BR (1) | BR112015015319A2 (https=) |
| CA (1) | CA2896288A1 (https=) |
| CR (1) | CR20150386A (https=) |
| HK (1) | HK1216611A1 (https=) |
| IL (1) | IL239593A0 (https=) |
| MX (1) | MX2015008361A (https=) |
| NI (1) | NI201500090A (https=) |
| NZ (1) | NZ630912A (https=) |
| PH (1) | PH12015501486B1 (https=) |
| RU (1) | RU2663687C2 (https=) |
| SG (1) | SG11201505111TA (https=) |
| WO (1) | WO2014105644A1 (https=) |
| ZA (1) | ZA201504762B (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405405A (zh) | 2002-12-09 | 2013-11-27 | 阿布拉西斯生物科学有限责任公司 | 组合物和传递药剂的方法 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| KR101420445B1 (ko) | 2005-08-31 | 2014-07-16 | 아브락시스 바이오사이언스, 엘엘씨 | 수 난용성 제약학적 약제 및 항균제를 포함하는 조성물 |
| EP3470071A1 (en) | 2006-12-14 | 2019-04-17 | Abraxis BioScience, LLC | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
| JP5579057B2 (ja) * | 2007-06-01 | 2014-08-27 | アブラクシス バイオサイエンス， エルエルシー | 再発性癌の処置のための方法および組成物 |
| HRP20192259T1 (hr) | 2009-04-15 | 2020-03-06 | Abraxis Bioscience, Llc | Pripravci nanočestica bez priona i metode njihove proizvodnje |
| CA3051495A1 (en) | 2010-03-26 | 2011-09-29 | Abraxis Bioscience, Llc | Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma |
| NZ717490A (en) | 2010-03-29 | 2017-12-22 | Abraxis Bioscience Llc | Methods of treating cancer |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| BR112012030909A2 (pt) | 2010-06-04 | 2020-08-18 | Abraxis Bioscience, Llc | métodos de tratamento de câncer pancreático |
| JP6038123B2 (ja) | 2011-04-28 | 2016-12-07 | アブラクシス バイオサイエンス， エルエルシー | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| PT2707030T (pt) | 2011-05-09 | 2020-05-22 | Mayo Found Medical Education & Res | Tratamentos de cancro |
| JP6216721B2 (ja) | 2011-12-14 | 2017-10-18 | アブラクシス バイオサイエンス， エルエルシー | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
| US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| EP3698784A1 (en) | 2013-03-12 | 2020-08-26 | Abraxis BioScience, LLC | Methods of treating lung cancer |
| EP2968191B1 (en) | 2013-03-14 | 2021-06-16 | Abraxis BioScience, LLC | Methods of treating bladder cancer |
| JP6387400B2 (ja) | 2013-05-30 | 2018-09-05 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 医薬組成物、その製造および使用 |
| US20160250351A1 (en) | 2014-06-13 | 2016-09-01 | Mayo Foundation For Medical Education And Research | Treating Lymphomas |
| EP3834889A1 (en) | 2014-06-16 | 2021-06-16 | Mayo Foundation for Medical Education and Research | Treating myelomas |
| CN104224750A (zh) * | 2014-09-17 | 2014-12-24 | 四川大学 | 一种注射用卡巴他赛白蛋白纳米粒制剂及其制备方法 |
| US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
| KR102666251B1 (ko) | 2014-11-25 | 2024-05-27 | 큐라디즘 | 약학적 조성물, 이의 제조 및 용도 |
| ES2951598T3 (es) | 2014-11-25 | 2023-10-23 | Curadigm Sas | Composición farmacéutica que combina al menos dos nanopartículas distintas y un compuesto farmacéutico, preparación y usos de los mismos |
| WO2016083331A1 (en) | 2014-11-25 | 2016-06-02 | Nanobiotix | Pharmaceutical composition, preparation and uses thereof |
| DK3223796T3 (da) | 2014-11-25 | 2021-09-27 | Curadigm Sas | Farmaceutiske sammensætninger, fremstilling og anvendelser deraf |
| US10527604B1 (en) * | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
| US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
| MA43100A (fr) | 2015-05-28 | 2018-09-05 | Nanobiotix | Nanoparticules à utiliser en tant que vaccin thérapeutique |
| PL3998069T3 (pl) | 2015-06-29 | 2025-03-31 | Abraxis Bioscience, Llc | Nanocząsteczki zawierające syrolimus i albuminę do zastosowania w leczeniu nowotworów z komórek nabłonkowatych |
| TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體－抗體組合物及其製造及使用方法 |
| TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
| WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
| WO2017139698A1 (en) | 2016-02-12 | 2017-08-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
| US11305020B2 (en) | 2016-03-21 | 2022-04-19 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
| EP3432928A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC |
| US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
| CN109890419A (zh) | 2016-09-01 | 2019-06-14 | 梅约医学教育与研究基金会 | 用于治疗癌症的载体-pd-l1结合剂组合物 |
| CA3035377A1 (en) | 2016-09-01 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Nanoparticle compositions for targeting t-cell cancers |
| WO2018048816A1 (en) | 2016-09-06 | 2018-03-15 | Mayo Foundation For Medical Education And Research | Methods of treating pd-l1 expressing cancer |
| US11590098B2 (en) | 2016-09-06 | 2023-02-28 | Mayo Foundation For Medical Education And Research | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
| EP3509643A1 (en) | 2016-09-06 | 2019-07-17 | Mayo Foundation for Medical Education and Research | Paclitaxel-albumin-binding agent compositions and methods for using and making the same |
| CN106420665B (zh) * | 2016-10-28 | 2019-04-16 | 浙江省林业科学研究院 | 一种包裹紫杉烷类药物的白蛋白纳米颗粒载体的制备方法 |
| KR20250057947A (ko) | 2017-10-03 | 2025-04-29 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| IL277402B1 (en) | 2018-03-20 | 2026-04-01 | Abraxis Bioscience Llc | Methods for treating central nervous system disorders using administration of MTOR inhibitor nanoparticles and albumin |
| US20220401374A1 (en) * | 2019-09-13 | 2022-12-22 | Purdue Research Foundation | Compositions and methods for cancer treatment by enhancing antitumor immunity using tannic acid-based nanocapsules |
| JP7832108B2 (ja) * | 2019-10-28 | 2026-03-17 | アブラクシス バイオサイエンス， エルエルシー | アルブミンおよびラパマイシンの医薬組成物 |
| BR112022009018A2 (pt) * | 2019-11-11 | 2022-10-11 | Abraxis Bioscience Llc | Biomarcadores para composições de nanopartícula |
| US20230074885A1 (en) * | 2020-02-05 | 2023-03-09 | The Johns Hopkins University | Bortezomib-loaded nanoparticles |
| US20240148918A1 (en) * | 2021-03-05 | 2024-05-09 | Board Of Regents, The University Of Texas System | Loading of Alginate Microspheres |
| KR102526793B1 (ko) * | 2021-11-03 | 2023-04-28 | 주식회사 에스엔바이오사이언스 | 입도분포 유지 안정성이 개선된 알부민 결합 탁산 나노입자 제조방법 |
| WO2024118542A1 (en) * | 2022-11-28 | 2024-06-06 | Takeda Vaccines, Inc. | A method for the quantitative determination of human serum albumin monomer in virus-containing pharmaceutical compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728553A (en) * | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US6749868B1 (en) * | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| WO2000006152A1 (en) * | 1998-07-30 | 2000-02-10 | Novopharm Biotech, Inc. | Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
| PL2470173T3 (pl) * | 2009-08-25 | 2016-11-30 | Leczenie skojarzone nanocząstkowymi kompozycjami taksanu i inhibitorów hedgehog | |
| CA3051495A1 (en) * | 2010-03-26 | 2011-09-29 | Abraxis Bioscience, Llc | Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma |
| WO2012092712A1 (zh) * | 2011-01-07 | 2012-07-12 | 无锡圆容生物医药股份有限公司 | 一种含有重组人血白蛋白的纳米颗粒冷冻干燥粉末制剂 |
| CN102078306A (zh) * | 2011-01-11 | 2011-06-01 | 无锡圆容生物医药股份有限公司 | 一种含有重组人血白蛋白的紫杉醇纳米颗粒冷冻干燥制剂 |
-
2013
- 2013-03-11 US US13/794,705 patent/US20140186447A1/en not_active Abandoned
- 2013-12-19 EP EP13868481.6A patent/EP2938340A4/en not_active Withdrawn
- 2013-12-19 MX MX2015008361A patent/MX2015008361A/es unknown
- 2013-12-19 JP JP2015550675A patent/JP2016504362A/ja active Pending
- 2013-12-19 BR BR112015015319A patent/BR112015015319A2/pt not_active Application Discontinuation
- 2013-12-19 NZ NZ630912A patent/NZ630912A/en unknown
- 2013-12-19 CA CA2896288A patent/CA2896288A1/en not_active Abandoned
- 2013-12-19 WO PCT/US2013/076630 patent/WO2014105644A1/en not_active Ceased
- 2013-12-19 KR KR1020157020337A patent/KR20150100903A/ko not_active Withdrawn
- 2013-12-19 AU AU2013370955A patent/AU2013370955B2/en active Active
- 2013-12-19 CN CN201380073926.7A patent/CN105007912A/zh active Pending
- 2013-12-19 HK HK16104504.3A patent/HK1216611A1/zh unknown
- 2013-12-19 SG SG11201505111TA patent/SG11201505111TA/en unknown
- 2013-12-19 RU RU2015131141A patent/RU2663687C2/ru active
-
2015
- 2015-06-23 IL IL239593A patent/IL239593A0/en unknown
- 2015-06-26 PH PH12015501486A patent/PH12015501486B1/en unknown
- 2015-06-26 NI NI201500090A patent/NI201500090A/es unknown
- 2015-07-02 ZA ZA2015/04762A patent/ZA201504762B/en unknown
- 2015-07-22 CR CR20150386A patent/CR20150386A/es unknown
-
2018
- 2018-02-23 JP JP2018030637A patent/JP2018087241A/ja active Pending
- 2018-10-25 US US16/170,522 patent/US20190192477A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NI201500090A (es) | 2015-12-22 |
| US20190192477A1 (en) | 2019-06-27 |
| RU2663687C2 (ru) | 2018-08-08 |
| CA2896288A1 (en) | 2014-07-03 |
| HK1216611A1 (zh) | 2016-11-25 |
| WO2014105644A1 (en) | 2014-07-03 |
| EP2938340A4 (en) | 2016-08-03 |
| AU2013370955B2 (en) | 2018-12-06 |
| CR20150386A (es) | 2015-10-07 |
| AU2013370955A1 (en) | 2015-07-16 |
| PH12015501486B1 (en) | 2020-12-16 |
| US20140186447A1 (en) | 2014-07-03 |
| PH12015501486A1 (en) | 2015-09-21 |
| CN105007912A (zh) | 2015-10-28 |
| RU2015131141A (ru) | 2017-02-03 |
| NZ630912A (en) | 2017-05-26 |
| JP2016504362A (ja) | 2016-02-12 |
| JP2018087241A (ja) | 2018-06-07 |
| EP2938340A1 (en) | 2015-11-04 |
| MX2015008361A (es) | 2016-03-11 |
| ZA201504762B (en) | 2016-10-26 |
| IL239593A0 (en) | 2015-08-31 |
| KR20150100903A (ko) | 2015-09-02 |
| SG11201505111TA (en) | 2015-07-30 |
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