BR112015004406A2 - método de amostragem e dispositivo sensor - Google Patents

método de amostragem e dispositivo sensor

Info

Publication number
BR112015004406A2
BR112015004406A2 BR112015004406A BR112015004406A BR112015004406A2 BR 112015004406 A2 BR112015004406 A2 BR 112015004406A2 BR 112015004406 A BR112015004406 A BR 112015004406A BR 112015004406 A BR112015004406 A BR 112015004406A BR 112015004406 A2 BR112015004406 A2 BR 112015004406A2
Authority
BR
Brazil
Prior art keywords
magnetic particles
detection surface
retained
magnetic
chamber
Prior art date
Application number
BR112015004406A
Other languages
English (en)
Inventor
Patrick Kelly Declan
Xiao Weimin
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of BR112015004406A2 publication Critical patent/BR112015004406A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0266—Investigating particle size or size distribution with electrical classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/0213—Measuring direction or magnitude of magnetic fields or magnetic flux using deviation of charged particles by the magnetic field
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

resumo método de amostragem e dispositivo sensor a invenção propõe um dispositivo sensor e um método de amostragem. o método compreende as etapas de: a. adicionar uma amostra a uma câmara em que existam partículas magnéticas, a amostra incluindo um componente desejado e a câmara tendo uma superfície de detecção; b. exercer uma força magnética sobre as partículas magnéticas para atrair as partículas magnéticas para a superfície de detecção, em que as partículas magnéticas ligadas que capturam o componente desejado nas partículas magnéticas são retidas na superfície de detecção, e partículas magnéticas não ligadas que não capturam componente desejado nas partículas magnéticas são também retidas na superfície de detecção; c. alterar a força magnética exercida sobre as partículas magnéticas e liberar as partículas magnéticas não ligadas da superfície de detecção; d. medir a quantidade das partículas magnéticas ligadas que são retidas na superfície de detecção; e. determinar se a quantidade das partículas magnéticas ligadas que são retidas na superfície de detecção está acima de um limite predeterminado; se não, realizar as seguintes etapas de: exercer a força magnética sobre as partículas magnéticas para atrair as partículas magnéticas para a superfície de detecção; drenar pelo menos parte da amostra para fora da câmara e adicionar uma nova amostra à câmara; alterar a força magnética exercida sobre as partículas magnéticas para liberar as partículas magnéticas não ligadas da superfície de detecção; e retornar para realizar as etapas b a e. 1/1
BR112015004406A 2012-09-04 2013-09-04 método de amostragem e dispositivo sensor BR112015004406A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012080969 2012-09-04
PCT/IB2013/058272 WO2014037880A1 (en) 2012-09-04 2013-09-04 A sensor device and a method of sampling

Publications (1)

Publication Number Publication Date
BR112015004406A2 true BR112015004406A2 (pt) 2017-07-04

Family

ID=49385311

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015004406A BR112015004406A2 (pt) 2012-09-04 2013-09-04 método de amostragem e dispositivo sensor

Country Status (6)

Country Link
US (1) US9841419B2 (pt)
EP (1) EP2893335A1 (pt)
JP (1) JP6363078B2 (pt)
BR (1) BR112015004406A2 (pt)
RU (1) RU2653145C2 (pt)
WO (1) WO2014037880A1 (pt)

Families Citing this family (8)

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WO2013102850A1 (en) 2012-01-04 2013-07-11 Insituto De Engenharia De Sistemas E Computadores Para Os Microsistemas E As Nanotecnologias Monolithic device combining cmos with magnetoresistive sensors
JP2015192957A (ja) * 2014-03-31 2015-11-05 株式会社Ｊｖｃケンウッド 撹拌装置及び攪拌方法
US9770600B1 (en) * 2014-07-09 2017-09-26 Verily Life Sciences Llc Particle concentration and separation using magnets
WO2016151143A1 (en) 2015-03-26 2016-09-29 Koninklijke Philips N.V. Manufacturing of a biosensor cartridge
CN117058415A (zh) * 2016-10-28 2023-11-14 贝克曼库尔特有限公司 物质准备评估系统
US20200306758A1 (en) * 2017-12-12 2020-10-01 Ancera Llc Systems, methods and devices for magnetic scanning for ferrofluid based assay
JP7455529B2 (ja) * 2019-08-01 2024-03-26 キヤノンメディカルシステムズ株式会社 検体測定装置及び検体測定装置の制御方法
JP7467137B2 (ja) * 2020-01-28 2024-04-15 キヤノンメディカルシステムズ株式会社 検体分析装置

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US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
CN101213452B (zh) 2005-05-02 2013-05-15 柏奥斯柯勒股份有限公司 利用声学器件检测分析物的方法和设备
CN101198871A (zh) * 2005-06-17 2008-06-11 皇家飞利浦电子股份有限公司 具有集成到达时间测量的快速磁性生物传感器
CN101198870A (zh) * 2005-06-17 2008-06-11 皇家飞利浦电子股份有限公司 精密磁性生物传感器
US8945946B2 (en) 2006-03-31 2015-02-03 Canon Kabushiki Kaisha Sensor element and detection method of magnetic particles using this element, and detection method of target substance
CN101438163B (zh) 2006-05-09 2013-05-29 皇家飞利浦电子股份有限公司 利用磁场检测样品中的靶分子
CN101438142B (zh) 2006-05-10 2013-10-30 皇家飞利浦电子股份有限公司 快速磁生物传感器
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RU2460058C2 (ru) * 2006-12-19 2012-08-27 Конинклейке Филипс Электроникс Н.В. Измерение параметров агглютинации
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Also Published As

Publication number Publication date
RU2015112284A (ru) 2016-10-27
EP2893335A1 (en) 2015-07-15
WO2014037880A1 (en) 2014-03-13
RU2653145C2 (ru) 2018-05-07
JP6363078B2 (ja) 2018-07-25
JP2015528571A (ja) 2015-09-28
US9841419B2 (en) 2017-12-12
US20150233908A1 (en) 2015-08-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements