BR112015000550B1 - Aparelho para mineralização de material biológico - Google Patents
Aparelho para mineralização de material biológico Download PDFInfo
- Publication number
- BR112015000550B1 BR112015000550B1 BR112015000550-0A BR112015000550A BR112015000550B1 BR 112015000550 B1 BR112015000550 B1 BR 112015000550B1 BR 112015000550 A BR112015000550 A BR 112015000550A BR 112015000550 B1 BR112015000550 B1 BR 112015000550B1
- Authority
- BR
- Brazil
- Prior art keywords
- mineralization
- agent
- probe
- biological material
- mineralizing
- Prior art date
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- 230000001089 mineralizing effect Effects 0.000 title claims abstract description 104
- 239000012620 biological material Substances 0.000 title claims abstract description 58
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- 239000000523 sample Substances 0.000 claims abstract description 73
- 238000002604 ultrasonography Methods 0.000 claims abstract description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 135
- 230000004044 response Effects 0.000 claims description 60
- 102000004169 proteins and genes Human genes 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 210000001519 tissue Anatomy 0.000 claims description 29
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- 238000012546 transfer Methods 0.000 claims description 13
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- 239000000463 material Substances 0.000 claims description 11
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- 238000000034 method Methods 0.000 abstract description 71
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 31
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 27
- 239000011707 mineral Substances 0.000 description 27
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 5
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- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 4
- 229910052712 strontium Inorganic materials 0.000 description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- GSFGEDGXDRCLDV-UHFFFAOYSA-H [Ca+2].P(=O)([O-])([O-])[O-].[F].P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2] Chemical compound [Ca+2].P(=O)([O-])([O-])[O-].[F].P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2] GSFGEDGXDRCLDV-UHFFFAOYSA-H 0.000 description 3
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- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
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- 230000002950 deficient Effects 0.000 description 3
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- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
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- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
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- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
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- 230000009610 hypersensitivity Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229940085991 phosphate ion Drugs 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
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- 238000012545 processing Methods 0.000 description 2
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- 235000019833 protease Nutrition 0.000 description 2
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- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
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- 238000012935 Averaging Methods 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
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- 108010035532 Collagen Proteins 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
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- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
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- 239000011573 trace mineral Substances 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
- A61C1/0007—Control devices or systems
- A61C1/0015—Electrical systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
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- A—HUMAN NECESSITIES
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- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/455—Phosphates containing halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
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| GB1212222.2 | 2012-07-10 | ||
| GB201212222A GB201212222D0 (en) | 2012-07-10 | 2012-07-10 | Improved apparatus and method for mineralising biological materials |
| PCT/GB2013/000296 WO2014009682A2 (en) | 2012-07-10 | 2013-07-09 | Improved apparatus and method for mineralising biological material |
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| BR112015000550A2 BR112015000550A2 (pt) | 2018-02-06 |
| BR112015000550B1 true BR112015000550B1 (pt) | 2021-07-27 |
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| EP (1) | EP2872213A2 (https=) |
| JP (1) | JP6548574B2 (https=) |
| CN (1) | CN104602756B (https=) |
| BR (1) | BR112015000550B1 (https=) |
| CA (1) | CA2878729C (https=) |
| GB (1) | GB201212222D0 (https=) |
| MX (1) | MX360251B (https=) |
| WO (1) | WO2014009682A2 (https=) |
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| US20170189149A1 (en) * | 2014-10-27 | 2017-07-06 | TCD Consulting LLC | Ultrasonic tooth cleaning apparatus and method |
| US20160113745A1 (en) * | 2014-10-27 | 2016-04-28 | TCD Consulting LLC | Ultrasonic tooth cleaning apparatus and method |
| CN108025165B (zh) * | 2015-09-09 | 2019-01-01 | 瑞文欧研究公司 | 用于将物质输送到骨骼中的装置 |
| WO2017091543A1 (en) | 2015-11-25 | 2017-06-01 | Corning Incorporated | Porous silicon compositions and devices and methods thereof |
| US10797221B2 (en) * | 2017-02-24 | 2020-10-06 | Baker Hughes, A Ge Company, Llc | Method for manufacturing an assembly for an ultrasonic probe |
| CN108938131A (zh) * | 2018-06-08 | 2018-12-07 | 南京医科大学附属口腔医院 | 一种用于治疗牙本质敏感的试剂盒 |
| EP3991690A1 (en) | 2020-10-27 | 2022-05-04 | Koninklijke Philips N.V. | Tooth remineralization |
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| US3019787A (en) * | 1960-10-05 | 1962-02-06 | Joe J Simmons | Apparatus for electrolytic dental desensitization |
| JPS5935208Y2 (ja) * | 1976-03-24 | 1984-09-29 | ライオン株式会社 | 超音波振動体 |
| JPS5347192A (en) * | 1976-10-13 | 1978-04-27 | Matsushita Electric Industrial Co Ltd | Device for introducing fluorine ion to tooth |
| GB9610101D0 (en) | 1996-05-15 | 1996-07-24 | Univ Dundee | Methods and apparatus for the detection of dental caries |
| AUPO566297A0 (en) * | 1997-03-13 | 1997-04-10 | University Of Melbourne, The | Calcium phosphopeptide complexes |
| DE19714167B4 (de) * | 1997-04-07 | 2010-01-28 | Hahn, Rainer, Dr. | Gerät zum Zuführen von Behandlungsmedium in Hartgewebe und Verwendung eines solchen |
| US6946142B2 (en) * | 2001-06-23 | 2005-09-20 | Lg Household & Healthcare Ltd. | Multi-layer patches for teeth whitening |
| US6801804B2 (en) * | 2002-05-03 | 2004-10-05 | Aciont, Inc. | Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis |
| CN1972642A (zh) * | 2004-07-09 | 2007-05-30 | 宝洁公司 | 口腔护理装置 |
| US20060008767A1 (en) * | 2004-07-09 | 2006-01-12 | The Procter & Gamble Company | Oral care devices |
| CA2589817A1 (en) | 2004-12-09 | 2006-06-15 | Palomar Medical Technologies, Inc. | Oral appliance with heat transfer mechanism |
| CN102008359B (zh) * | 2005-05-03 | 2013-08-21 | 乌尔特里奥公司 | 采用声波导波管的口腔卫生装置 |
| EP2705826B1 (en) | 2006-02-09 | 2019-09-11 | The University of Melbourne | Fluoride composition and methods for dental mineralization |
| NZ574160A (en) * | 2006-06-15 | 2011-09-30 | Seagull Ip Pty Ltd | A delivery system and process for applying an electric field and an ultrasonic signal |
| US20100143423A1 (en) * | 2006-12-05 | 2010-06-10 | Michael Francis Butler | Oral care product |
| KR100870232B1 (ko) | 2006-12-07 | 2008-11-24 | 재단법인서울대학교산학협력재단 | 치아용 미백기능성 물질 전달시스템 |
| GB0807224D0 (en) * | 2008-04-21 | 2008-05-28 | Univ Dundee | Remineralisation of calcified tissue |
| GB0815051D0 (en) * | 2008-08-18 | 2008-09-24 | Univ Dundee | Apparatus and method for mineralising biological materials |
| MX2011005567A (es) | 2008-11-25 | 2012-01-25 | Procter & Gamble | Composiciones para el cuidado bucal con estetica mejorada y silicio fundido. |
| JP2010155786A (ja) * | 2008-12-26 | 2010-07-15 | Nsp:Kk | 歯牙の再石灰化剤及び再石灰化方法 |
| WO2011084607A1 (en) * | 2009-12-17 | 2011-07-14 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
| US9327105B2 (en) * | 2010-03-26 | 2016-05-03 | Itrace Biomedical Inc. | Active transdermal drug delivery system and the method thereof |
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2012
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2013
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- 2013-07-09 MX MX2015000375A patent/MX360251B/es active IP Right Grant
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Also Published As
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| JP2015521931A (ja) | 2015-08-03 |
| US10076392B2 (en) | 2018-09-18 |
| BR112015000550A2 (pt) | 2018-02-06 |
| JP6548574B2 (ja) | 2019-07-24 |
| EP2872213A2 (en) | 2015-05-20 |
| US20150125808A1 (en) | 2015-05-07 |
| CN104602756B (zh) | 2018-10-19 |
| GB201212222D0 (en) | 2012-08-22 |
| CA2878729A1 (en) | 2014-01-16 |
| MX2015000375A (es) | 2015-11-23 |
| CA2878729C (en) | 2022-05-17 |
| WO2014009682A8 (en) | 2014-05-22 |
| MX360251B (es) | 2018-10-26 |
| WO2014009682A2 (en) | 2014-01-16 |
| CN104602756A (zh) | 2015-05-06 |
| WO2014009682A3 (en) | 2014-03-20 |
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