BR112014015603B1 - métodos para sondagem de múltiplos alvos em uma amostra biológica e para análise da amostra biológica de multiplexação de alta produtividade. - Google Patents
métodos para sondagem de múltiplos alvos em uma amostra biológica e para análise da amostra biológica de multiplexação de alta produtividade. Download PDFInfo
- Publication number
- BR112014015603B1 BR112014015603B1 BR112014015603A BR112014015603A BR112014015603B1 BR 112014015603 B1 BR112014015603 B1 BR 112014015603B1 BR 112014015603 A BR112014015603 A BR 112014015603A BR 112014015603 A BR112014015603 A BR 112014015603A BR 112014015603 B1 BR112014015603 B1 BR 112014015603B1
- Authority
- BR
- Brazil
- Prior art keywords
- biological sample
- probe
- methods
- sample
- multiple targets
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 239000012472 biological sample Substances 0.000 title abstract 6
- 239000000523 sample Substances 0.000 abstract 10
- 238000004061 bleaching Methods 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 230000027756 respiratory electron transport chain Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/336,409 US8568991B2 (en) | 2011-12-23 | 2011-12-23 | Photoactivated chemical bleaching of dyes |
| PCT/US2012/067527 WO2013095896A1 (en) | 2011-12-23 | 2012-12-03 | Photoactivated chemical bleaching of dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014015603A2 BR112014015603A2 (pt) | 2017-06-13 |
| BR112014015603A8 BR112014015603A8 (pt) | 2017-07-04 |
| BR112014015603B1 true BR112014015603B1 (pt) | 2020-04-28 |
Family
ID=48655136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014015603A BR112014015603B1 (pt) | 2011-12-23 | 2012-12-03 | métodos para sondagem de múltiplos alvos em uma amostra biológica e para análise da amostra biológica de multiplexação de alta produtividade. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8568991B2 (https=) |
| EP (1) | EP2794908B1 (https=) |
| JP (1) | JP6148682B2 (https=) |
| KR (1) | KR102046194B1 (https=) |
| CN (1) | CN104114713B (https=) |
| AU (1) | AU2012355736B2 (https=) |
| BR (1) | BR112014015603B1 (https=) |
| CA (1) | CA2860097C (https=) |
| RU (1) | RU2623880C2 (https=) |
| SG (1) | SG11201403460SA (https=) |
| WO (1) | WO2013095896A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3098487B2 (ja) | 1998-01-29 | 2000-10-16 | 日本電気株式会社 | 光ケーブル導入構造及び光ケーブル導入接続方法 |
| US11573235B2 (en) | 2012-03-30 | 2023-02-07 | Leica Microsystems Cms Gmbh | Methods for generating an image of a biological sample |
| RU2015120176A (ru) * | 2012-12-11 | 2017-01-19 | Клариент Дайагностик Сервисез, Инк. | Фотоактивированное химическое обесцвечивание красителей |
| US10677802B2 (en) * | 2012-12-17 | 2020-06-09 | Ge Healthcare Bio-Sciences Corp. | Chemical bleaching of dyes using radical photoinitiators |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| US10718011B2 (en) * | 2014-02-12 | 2020-07-21 | The Trustees Of Columbia University In The City Of New York | Single molecule electronic multiplex SNP assay and PCR analysis |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| EP3256857B1 (en) * | 2015-02-13 | 2019-07-24 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| CN105044059B (zh) * | 2015-07-13 | 2017-08-29 | 深圳市瀚海基因生物科技有限公司 | 一种可用于减缓单分子荧光漂白现象的除氧试剂及其应用方法 |
| US20170241911A1 (en) * | 2016-02-22 | 2017-08-24 | Miltenyi Biotec Gmbh | Automated analysis tool for biological specimens |
| KR102478639B1 (ko) | 2016-02-23 | 2022-12-19 | 노을 주식회사 | 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치 |
| KR20170099739A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법 |
| US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
| WO2018094113A1 (en) | 2016-11-16 | 2018-05-24 | University Of Washington | Systems and methods for cyclic fluorescence imaging |
| CZ309221B6 (cs) * | 2018-09-27 | 2022-06-01 | Mendelova Univerzita V Brně | Způsob identifikace přírodních vzorků, zejména kapalných |
| AU2022388928A1 (en) | 2021-11-16 | 2024-05-16 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| US20230140613A1 (en) * | 2022-03-30 | 2023-05-04 | Hasan Bagheri | Colorimetric system for detection of covid-19 using exhaled breath metabolites |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78065B (https=) | 1982-02-19 | 1984-09-26 | Unilever Nv | |
| DK39592D0 (da) | 1992-03-25 | 1992-03-25 | Safefood Micro Systsm As | Method of detecting microorganisms |
| US6451551B1 (en) | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
| ATE278801T1 (de) | 1995-11-22 | 2004-10-15 | Medtronic Minimed Inc | Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| CA2392534A1 (en) | 1999-11-30 | 2001-06-07 | Oncosis | Method and apparatus for selectively targeting specific cells within a cell population |
| DE10014685B4 (de) | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| AU2001253193A1 (en) | 2000-04-04 | 2001-10-15 | The Regents Of The University Of California | Fluorescent lifetime assays for non-invasive quantification of analytes |
| US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| DE10117430A1 (de) | 2001-04-06 | 2002-10-10 | Nicole Marme | Hochempfindlicher und hochspezifischer Enzymnachweis mit einer Nachweisgrenze bis in den femtomolaren Bereich |
| US7045361B2 (en) | 2001-09-12 | 2006-05-16 | Medtronic Minimed, Inc. | Analyte sensing via acridine-based boronate biosensors |
| US8062897B2 (en) | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| RU2305270C2 (ru) | 2005-05-18 | 2007-08-27 | Андрей Алексеевич Климов | Способ флуоресцентной наноскопии (варианты) |
| EP2027465A2 (en) | 2006-05-17 | 2009-02-25 | Cellumen, Inc. | Method for automated tissue analysis |
| US7993927B2 (en) | 2006-07-03 | 2011-08-09 | Beth Israel Deaconess Medical Center, Inc. | Histology methods |
| US8131476B2 (en) | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US20080032321A1 (en) | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US20080124310A1 (en) | 2006-11-01 | 2008-05-29 | Marshall John G | Bead based receptor biology |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US20100216652A1 (en) | 2007-04-25 | 2010-08-26 | The Trustees Of The Universit Of Pennsylvania | Low Level Fluorescence Detection at the Light Microscopic Level |
| US7714303B2 (en) | 2007-05-10 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for analyzing fluorescent materials with reduced authofluorescence |
| US20090263612A1 (en) | 2008-04-18 | 2009-10-22 | Nbc Universal, Inc. | System and Method for Photobleaching of Optical Media |
| US9677125B2 (en) | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2601513B1 (en) | 2010-08-05 | 2014-05-14 | Cambridge Research & Instrumentation, Inc. | Enhancing visual assessment of samples |
| US20140024024A1 (en) | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
-
2011
- 2011-12-23 US US13/336,409 patent/US8568991B2/en not_active Expired - Fee Related
-
2012
- 2012-12-03 KR KR1020147020366A patent/KR102046194B1/ko not_active Expired - Fee Related
- 2012-12-03 CN CN201280070449.4A patent/CN104114713B/zh active Active
- 2012-12-03 BR BR112014015603A patent/BR112014015603B1/pt not_active IP Right Cessation
- 2012-12-03 AU AU2012355736A patent/AU2012355736B2/en not_active Ceased
- 2012-12-03 CA CA2860097A patent/CA2860097C/en active Active
- 2012-12-03 EP EP12860159.8A patent/EP2794908B1/en active Active
- 2012-12-03 JP JP2014549074A patent/JP6148682B2/ja active Active
- 2012-12-03 RU RU2014124974A patent/RU2623880C2/ru active
- 2012-12-03 WO PCT/US2012/067527 patent/WO2013095896A1/en not_active Ceased
- 2012-12-03 SG SG11201403460SA patent/SG11201403460SA/en unknown
-
2013
- 2013-08-27 US US14/010,889 patent/US9250245B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20130165330A1 (en) | 2013-06-27 |
| AU2012355736A2 (en) | 2014-09-18 |
| RU2014124974A (ru) | 2016-02-20 |
| SG11201403460SA (en) | 2014-07-30 |
| WO2013095896A1 (en) | 2013-06-27 |
| CN104114713A (zh) | 2014-10-22 |
| US8568991B2 (en) | 2013-10-29 |
| CA2860097A1 (en) | 2013-06-27 |
| NZ626334A (en) | 2016-04-29 |
| CN104114713B (zh) | 2018-04-03 |
| KR102046194B1 (ko) | 2019-11-18 |
| US9250245B2 (en) | 2016-02-02 |
| EP2794908B1 (en) | 2017-08-02 |
| EP2794908A4 (en) | 2015-05-06 |
| EP2794908A1 (en) | 2014-10-29 |
| JP6148682B2 (ja) | 2017-06-14 |
| JP2015506469A (ja) | 2015-03-02 |
| RU2623880C2 (ru) | 2017-06-29 |
| BR112014015603A8 (pt) | 2017-07-04 |
| US20130345089A1 (en) | 2013-12-26 |
| BR112014015603A2 (pt) | 2017-06-13 |
| AU2012355736B2 (en) | 2017-12-14 |
| AU2012355736A1 (en) | 2014-07-17 |
| KR20140103350A (ko) | 2014-08-26 |
| CA2860097C (en) | 2020-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/12/2012, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2751 DE 26-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |