BR112014014046A2 - composto, composição, e, método para tratar hiv - Google Patents
composto, composição, e, método para tratar hivInfo
- Publication number
- BR112014014046A2 BR112014014046A2 BR112014014046A BR112014014046A BR112014014046A2 BR 112014014046 A2 BR112014014046 A2 BR 112014014046A2 BR 112014014046 A BR112014014046 A BR 112014014046A BR 112014014046 A BR112014014046 A BR 112014014046A BR 112014014046 A2 BR112014014046 A2 BR 112014014046A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- composition
- treating hiv
- hiv
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011002105 | 2011-12-14 | ||
| PCT/CN2011/002159 WO2013091144A1 (en) | 2011-12-21 | 2011-12-21 | Propenoate derivatives of betulin |
| PCT/US2012/069688 WO2013090683A1 (en) | 2011-12-14 | 2012-12-14 | Propenoate derivatives of betulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014014046A2 true BR112014014046A2 (pt) | 2017-06-13 |
Family
ID=48613201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014014046A BR112014014046A2 (pt) | 2011-12-14 | 2012-12-14 | composto, composição, e, método para tratar hiv |
Country Status (12)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| WO2014093941A1 (en) | 2012-12-14 | 2014-06-19 | Glaxosmithkline Llc | Pharmaceutical compositions |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| CN106999425A (zh) | 2014-09-26 | 2017-08-01 | 葛兰素史克知识产权第二有限公司 | 长效药物组合物 |
| US9914747B2 (en) * | 2014-11-14 | 2018-03-13 | VIIV Healthcare UK (No.5) Limited | Extended betulinic acid analogs |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| WO2016147099A2 (en) | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors |
| AR107512A1 (es) * | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| WO2019150300A1 (en) | 2018-02-02 | 2019-08-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| TW200837074A (en) * | 2006-11-03 | 2008-09-16 | Panacos Pharmaceuticals Inc | Extended triterpene derivatives |
| CA2744908A1 (en) * | 2007-12-04 | 2009-06-11 | Myrexis, Inc. | Compounds and therapeutic use thereof |
| AU2008342537A1 (en) * | 2008-01-03 | 2009-07-09 | Virochem Pharma Inc. | Novel lupane derivatives |
| CN101328201A (zh) * | 2008-07-29 | 2008-12-24 | 浙江大学 | 一种从桦树皮中提取白桦脂醇的方法 |
| US9067966B2 (en) * | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
| CN101709322B (zh) * | 2009-11-26 | 2012-06-27 | 浙江大学 | 生物催化白桦脂醇合成白桦脂酸的方法 |
| CN101704874A (zh) * | 2009-11-26 | 2010-05-12 | 中国药科大学 | 五环三萜及其衍生物的二甲双胍盐、其制备方法及医药用途 |
| AU2011215986A1 (en) * | 2010-02-11 | 2012-08-30 | Glaxosmithkline Llc | Derivatives of betulin |
-
2012
- 2012-12-14 RU RU2014122866A patent/RU2613554C2/ru not_active IP Right Cessation
- 2012-12-14 AU AU2012352129A patent/AU2012352129B2/en not_active Ceased
- 2012-12-14 IN IN4449CHN2014 patent/IN2014CN04449A/en unknown
- 2012-12-14 CA CA2859032A patent/CA2859032A1/en not_active Abandoned
- 2012-12-14 EP EP12856832.6A patent/EP2791102B1/en active Active
- 2012-12-14 WO PCT/US2012/069688 patent/WO2013090683A1/en active Application Filing
- 2012-12-14 ES ES12856832.6T patent/ES2584684T3/es active Active
- 2012-12-14 BR BR112014014046A patent/BR112014014046A2/pt not_active Application Discontinuation
- 2012-12-14 CN CN201280069633.7A patent/CN104271550B/zh not_active Expired - Fee Related
- 2012-12-14 US US14/364,409 patent/US9340513B2/en not_active Expired - Fee Related
- 2012-12-14 KR KR1020147019366A patent/KR20140101869A/ko active IP Right Grant
- 2012-12-14 JP JP2014547472A patent/JP6091520B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2014122866A (ru) | 2016-02-10 |
| CA2859032A1 (en) | 2013-06-20 |
| CN104271550B (zh) | 2016-09-07 |
| IN2014CN04449A (US06815460-20041109-C00097.png) | 2015-09-04 |
| RU2613554C2 (ru) | 2017-03-17 |
| EP2791102B1 (en) | 2016-05-18 |
| WO2013090683A1 (en) | 2013-06-20 |
| AU2012352129B2 (en) | 2016-02-04 |
| JP2015501846A (ja) | 2015-01-19 |
| EP2791102A4 (en) | 2015-04-22 |
| ES2584684T3 (es) | 2016-09-28 |
| EP2791102A1 (en) | 2014-10-22 |
| JP6091520B2 (ja) | 2017-03-08 |
| CN104271550A (zh) | 2015-01-07 |
| AU2012352129A1 (en) | 2014-08-07 |
| US20140350032A1 (en) | 2014-11-27 |
| US9340513B2 (en) | 2016-05-17 |
| KR20140101869A (ko) | 2014-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |