BR112014009624A2 - piridina-sulfoximinas como inibidores de tirosina cinase - Google Patents

piridina-sulfoximinas como inibidores de tirosina cinase

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Publication number
BR112014009624A2
BR112014009624A2 BR112014009624A BR112014009624A BR112014009624A2 BR 112014009624 A2 BR112014009624 A2 BR 112014009624A2 BR 112014009624 A BR112014009624 A BR 112014009624A BR 112014009624 A BR112014009624 A BR 112014009624A BR 112014009624 A2 BR112014009624 A2 BR 112014009624A2
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BR
Brazil
Prior art keywords
tyrosine kinase
sulfoximines
pyridine
kinase inhibitors
modulate
Prior art date
Application number
BR112014009624A
Other languages
English (en)
Inventor
A Wurster Julie
Wang Shimiao
Boral Sougato
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112014009624A2 publication Critical patent/BR112014009624A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

abstract of the disclosure the present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. __________________ tradução do resumo resumo patente de invenção: "piridina-sulfoximinas como inibidores de tirosina cinase". a presente invenção se refere a moléculas orgânicas de formula (i) capazes de modular transdução de sinal de tirosina cinase a fim de re-gular, modular e/ou inibir proliferação celular anormal.
BR112014009624A 2011-10-20 2012-10-18 piridina-sulfoximinas como inibidores de tirosina cinase BR112014009624A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/277,842 US8558002B2 (en) 2006-11-16 2011-10-20 Sulfoximines as kinase inhibitors
PCT/US2012/060749 WO2013062843A1 (en) 2011-10-20 2012-10-18 Pyridine- sulfoximines as tyrosine kinase inhibitors

Publications (1)

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BR112014009624A2 true BR112014009624A2 (pt) 2017-05-09

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BR112014009624A BR112014009624A2 (pt) 2011-10-20 2012-10-18 piridina-sulfoximinas como inibidores de tirosina cinase

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US (1) US8558002B2 (pt)
EP (1) EP2768809B1 (pt)
JP (1) JP6067723B2 (pt)
KR (1) KR20140085522A (pt)
CN (1) CN103998431A (pt)
AU (1) AU2012329176A1 (pt)
BR (1) BR112014009624A2 (pt)
CA (1) CA2853062A1 (pt)
IN (1) IN2014DN03295A (pt)
RU (1) RU2014119705A (pt)
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US8558002B2 (en) 2013-10-15
CN103998431A (zh) 2014-08-20
WO2013062843A1 (en) 2013-05-02
IN2014DN03295A (pt) 2015-06-26
CA2853062A1 (en) 2013-05-02
JP6067723B2 (ja) 2017-01-25
JP2014530865A (ja) 2014-11-20
EP2768809B1 (en) 2016-03-09
EP2768809A1 (en) 2014-08-27
KR20140085522A (ko) 2014-07-07
US20120196902A1 (en) 2012-08-02
AU2012329176A1 (en) 2014-05-15

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