BR112014006844A2 - composições e métodos relacionados ao ácido deoxicólico e seus polimorfos - Google Patents

composições e métodos relacionados ao ácido deoxicólico e seus polimorfos

Info

Publication number
BR112014006844A2
BR112014006844A2 BR112014006844A BR112014006844A BR112014006844A2 BR 112014006844 A2 BR112014006844 A2 BR 112014006844A2 BR 112014006844 A BR112014006844 A BR 112014006844A BR 112014006844 A BR112014006844 A BR 112014006844A BR 112014006844 A2 BR112014006844 A2 BR 112014006844A2
Authority
BR
Brazil
Prior art keywords
compositions
dca
deoxycholic acid
polymorphs
methods
Prior art date
Application number
BR112014006844A
Other languages
English (en)
Inventor
Prasad Achampeta
Gregory Reid John
Knight John
Holman Nicholas
Steinbrink Randy
Subramanian Sankar
Pfeiffer Steven
Sun Xufeng
Original Assignee
Kythera Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TW101121290A external-priority patent/TWI572616B/zh
Application filed by Kythera Biopharmaceuticals Inc filed Critical Kythera Biopharmaceuticals Inc
Priority claimed from PCT/US2012/056691 external-priority patent/WO2013044119A1/en
Publication of BR112014006844A2 publication Critical patent/BR112014006844A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

abstract provided herein are polymorphic forms of deoxycholic acid (dca), improved methods of synthesizing dca and intermediates thereto, and compositions and fat removal methods employing the dca as provided herein. 24 tradução do resumo resumo patente de invenção: "composições e métodos relacionados ao ácido deoxicólico e seus polimorfos". são proporcionadas aqui formas polimórficas de ácido deoxicólico (dca), métodos aprimorados de síntese de dca e intermediários do mesmo e composições e métodos de remoção de gordura empregando o dca conforme fornecido aqui.
BR112014006844A 2011-09-22 2012-09-21 composições e métodos relacionados ao ácido deoxicólico e seus polimorfos BR112014006844A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161538084P 2011-09-22 2011-09-22
US201161558375P 2011-11-10 2011-11-10
US201261659920P 2012-06-14 2012-06-14
TW101121290A TWI572616B (zh) 2011-06-16 2012-06-14 去氧膽酸之組成物及用途及其相關方法
PCT/US2012/056691 WO2013044119A1 (en) 2011-09-22 2012-09-21 Compositions and methods related to deoxycholic acid and its polymorphs

Publications (1)

Publication Number Publication Date
BR112014006844A2 true BR112014006844A2 (pt) 2017-04-04

Family

ID=48136454

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014006844A BR112014006844A2 (pt) 2011-09-22 2012-09-21 composições e métodos relacionados ao ácido deoxicólico e seus polimorfos

Country Status (5)

Country Link
US (1) US20130102580A1 (pt)
CN (1) CN103906517A (pt)
BR (1) BR112014006844A2 (pt)
CA (1) CA2849369C (pt)
TW (3) TWI627180B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
CN110412167A (zh) * 2019-08-07 2019-11-05 南京明捷生物医药检测有限公司 一种测定盐酸西那卡塞中2,2,6,6-四甲基哌啶氧化物含量的方法
WO2023192221A1 (en) * 2022-03-29 2023-10-05 Bilayer Therapeutics, Inc. Forms and compositions of sodium chenodeoxycholate
CN115894594A (zh) * 2022-11-17 2023-04-04 上海皓元生物医药科技有限公司 一种去氧胆酸中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2407475T3 (en) * 2007-06-19 2015-10-26 Kythera Biopharmaceuticals Inc Preparation of synthetic bile acid
GB2480632A (en) * 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
EP2721047B1 (en) * 2011-06-16 2016-11-16 Kythera Biopharmaceuticals, Inc. Methods for the synthesis and purification of deoxycholic acid

Also Published As

Publication number Publication date
TWI554516B (zh) 2016-10-21
US20130102580A1 (en) 2013-04-25
TWI627180B (zh) 2018-06-21
CA2849369C (en) 2015-06-02
TWI679979B (zh) 2019-12-21
CA2849369A1 (en) 2013-03-28
TW201319082A (zh) 2013-05-16
CN103906517A (zh) 2014-07-02
TW201831189A (zh) 2018-09-01
TW201700494A (zh) 2017-01-01

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL