BR112014001989A2 - ésteres n,n-dialquilalquilenílicos, composições dos mesmos, e métodos para uso dos mesmos - Google Patents

ésteres n,n-dialquilalquilenílicos, composições dos mesmos, e métodos para uso dos mesmos

Info

Publication number
BR112014001989A2
BR112014001989A2 BR112014001989A BR112014001989A BR112014001989A2 BR 112014001989 A2 BR112014001989 A2 BR 112014001989A2 BR 112014001989 A BR112014001989 A BR 112014001989A BR 112014001989 A BR112014001989 A BR 112014001989A BR 112014001989 A2 BR112014001989 A2 BR 112014001989A2
Authority
BR
Brazil
Prior art keywords
esters
dialkylalkylenyl
methods
compositions
stability
Prior art date
Application number
BR112014001989A
Other languages
English (en)
Inventor
W Old David
M Burk Robert
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112014001989A2 publication Critical patent/BR112014001989A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

abstract of the invention the invention provides well defined n,n-dialkylalkenyl ester compounds for treating glaucoma or ocular hypertension. the esters of the invention are particularly advantageous due to their stability in aqueous solutions. ------------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "ésteres n,n-dialquilalquilenílicos, com-posições dos mesmos, e métodos para uso dos mesmos". a invenção oferece compostos do tipo éster n,n-dialquilalque-nílico bem definidos para o tratamento de glaucoma ou hipertensão ocular. os ésteres da invenção são particularmente vantajosos devido a sua estabi-lidade em soluções aquosas.
BR112014001989A 2011-07-27 2012-07-27 ésteres n,n-dialquilalquilenílicos, composições dos mesmos, e métodos para uso dos mesmos BR112014001989A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161512119P 2011-07-27 2011-07-27
PCT/US2012/048662 WO2013016677A1 (en) 2011-07-27 2012-07-27 N,n-dialkylalkylenyl esters, compositions thereof, and methods for use thereof

Publications (1)

Publication Number Publication Date
BR112014001989A2 true BR112014001989A2 (pt) 2017-02-21

Family

ID=46939970

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001989A BR112014001989A2 (pt) 2011-07-27 2012-07-27 ésteres n,n-dialquilalquilenílicos, composições dos mesmos, e métodos para uso dos mesmos

Country Status (10)

Country Link
US (1) US8609658B2 (pt)
EP (1) EP2736880A1 (pt)
JP (1) JP2014524935A (pt)
KR (1) KR20140050080A (pt)
CN (1) CN103764622A (pt)
AU (1) AU2012286692A1 (pt)
BR (1) BR112014001989A2 (pt)
CA (1) CA2843273A1 (pt)
RU (1) RU2014106785A (pt)
WO (1) WO2013016677A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2755944B1 (en) 2011-09-16 2017-06-14 Sanofi Biarylderivatives,their preparation and their therapeutic application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JP2011510965A (ja) * 2008-02-05 2011-04-07 アステランド ユーケー リミテッド 高眼圧症の治療のためのジフルオロビフェニルアミド誘導体

Also Published As

Publication number Publication date
EP2736880A1 (en) 2014-06-04
US8609658B2 (en) 2013-12-17
KR20140050080A (ko) 2014-04-28
AU2012286692A1 (en) 2014-02-20
CN103764622A (zh) 2014-04-30
US20130029992A1 (en) 2013-01-31
CA2843273A1 (en) 2013-01-31
RU2014106785A (ru) 2015-09-10
JP2014524935A (ja) 2014-09-25
WO2013016677A1 (en) 2013-01-31

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]