BR112013032088B1 - produtos farmacêuticos anti-inflamatórios - Google Patents

produtos farmacêuticos anti-inflamatórios Download PDF

Info

Publication number
BR112013032088B1
BR112013032088B1 BR112013032088-5A BR112013032088A BR112013032088B1 BR 112013032088 B1 BR112013032088 B1 BR 112013032088B1 BR 112013032088 A BR112013032088 A BR 112013032088A BR 112013032088 B1 BR112013032088 B1 BR 112013032088B1
Authority
BR
Brazil
Prior art keywords
polypeptide
seq
residue
present
residues
Prior art date
Application number
BR112013032088-5A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112013032088A2 (pt
Inventor
Angelo P. Consalvo
Nozer M. Mehta
Mauro Perretti
Jesmond Dalli
Original Assignee
Resother Pharma Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resother Pharma Aps filed Critical Resother Pharma Aps
Publication of BR112013032088A2 publication Critical patent/BR112013032088A2/pt
Publication of BR112013032088B1 publication Critical patent/BR112013032088B1/pt

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721Lipocortins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BR112013032088-5A 2011-06-15 2012-06-15 produtos farmacêuticos anti-inflamatórios BR112013032088B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161497270P 2011-06-15 2011-06-15
US61/497,270 2011-06-15
PCT/US2012/042699 WO2012174397A2 (en) 2011-06-15 2012-06-15 Anti-inflammatory pharmaceutical products
US13/524,381 2012-06-15
US13/524,381 US9102753B2 (en) 2011-06-15 2012-06-15 Anti-inflammatory pharmaceutical products

Publications (2)

Publication Number Publication Date
BR112013032088A2 BR112013032088A2 (pt) 2016-11-22
BR112013032088B1 true BR112013032088B1 (pt) 2020-11-24

Family

ID=47357770

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013032088-5A BR112013032088B1 (pt) 2011-06-15 2012-06-15 produtos farmacêuticos anti-inflamatórios

Country Status (12)

Country Link
US (2) US9102753B2 (https=)
EP (2) EP3533457B1 (https=)
JP (1) JP6069663B2 (https=)
CN (1) CN103764669B (https=)
AU (1) AU2012271453B2 (https=)
BR (1) BR112013032088B1 (https=)
CA (1) CA2839298C (https=)
DK (1) DK2720707T3 (https=)
ES (1) ES2712805T3 (https=)
HU (1) HUE042929T2 (https=)
PL (1) PL2720707T3 (https=)
WO (1) WO2012174397A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
US9102753B2 (en) * 2011-06-15 2015-08-11 Ugp Therapeutics, Inc. Anti-inflammatory pharmaceutical products
US9457086B2 (en) 2013-03-05 2016-10-04 Enteris Biopharma, Inc. Pharmaceuticals for oral delivery
DK3244878T3 (da) 2015-01-12 2022-10-17 Enteris Biopharma Inc Faste orale sammensætningsformer
PL4200319T3 (pl) 2020-08-21 2025-08-18 Resother Pharma A/S Preparaty peptydu n-końcowego aneksyny a1 i sposoby
CN118891273A (zh) 2022-02-23 2024-11-01 雷索特制药股份有限公司 膜联蛋白a1衍生的多肽类似物
US20250345392A1 (en) 2022-06-30 2025-11-13 Resother Pharma A/S Annexin a1 liquid pharmaceutical composition
AU2024234229A1 (en) 2023-03-13 2025-09-25 Resother Pharma A/S Annexin a1 administration regime
EP4680262A1 (en) 2023-03-13 2026-01-21 Resother Pharma A/S Annexin a1 delayed dosing

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US4708934A (en) 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US5789234A (en) 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
WO1998046722A1 (en) 1997-04-16 1998-10-22 Unigene Laboratories Inc. Direct expression of peptides into culture media
US6086018A (en) 1997-12-09 2000-07-11 Mcdonnell Douglas Corporation Interlocking assembly system for an aircraft cabin
US20090163578A1 (en) * 2004-10-01 2009-06-25 University Of Medicine And Dentistry Of New Jersey Novel modification of immunomodulatory protein
US7445911B2 (en) 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
AU2006261909B2 (en) 2005-06-24 2011-08-11 Enteris Biopharma, Inc. Cell lines for expressing enzyme useful in the preparation of amidated products
CN101287503A (zh) * 2005-08-03 2008-10-15 Rq生物科技有限公司 用于诊断IgA和IgM介导的肾脏疾病的方法和组合物
CN101273059B (zh) 2005-08-26 2014-02-19 艾伯维有限公司 治疗活性的α-MSH类似物
US8691764B2 (en) * 2007-03-28 2014-04-08 The Research Foundation For The State University Of New York Inhibitors of NF-κB activity
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
GB0724953D0 (en) 2007-12-20 2008-01-30 Lytix Biopharma As Methods of peptide modification
EP2349321B1 (en) 2008-10-17 2020-04-22 London Health Sciences Centre Research Inc. Annexin and its use to treat inflammatory disorders
US8940697B2 (en) * 2009-10-16 2015-01-27 Duke University Compositions and methods for the treatment of myocardial ischemia/reperfusion injury with Annexin A1 short peptide
US9102753B2 (en) * 2011-06-15 2015-08-11 Ugp Therapeutics, Inc. Anti-inflammatory pharmaceutical products

Also Published As

Publication number Publication date
EP3533457B1 (en) 2021-08-11
CN103764669B (zh) 2017-08-15
ES2712805T3 (es) 2019-05-14
US20150315256A1 (en) 2015-11-05
US9102753B2 (en) 2015-08-11
PL2720707T3 (pl) 2019-06-28
HUE042929T2 (hu) 2019-07-29
CA2839298C (en) 2021-05-18
CN103764669A (zh) 2014-04-30
DK2720707T3 (en) 2019-04-08
AU2012271453A1 (en) 2013-12-19
CA2839298A1 (en) 2012-12-20
EP3533457A1 (en) 2019-09-04
EP2720707B1 (en) 2018-12-19
WO2012174397A2 (en) 2012-12-20
US10072055B2 (en) 2018-09-11
WO2012174397A3 (en) 2013-02-28
JP6069663B2 (ja) 2017-02-01
US20130072446A1 (en) 2013-03-21
JP2014519526A (ja) 2014-08-14
EP2720707A4 (en) 2015-05-06
BR112013032088A2 (pt) 2016-11-22
EP2720707A2 (en) 2014-04-23
AU2012271453B2 (en) 2017-07-06

Similar Documents

Publication Publication Date Title
BR112013032088B1 (pt) produtos farmacêuticos anti-inflamatórios
JP7621728B2 (ja) プロテアーゼ活性化受容体2のモジュレーター
CN116323649A (zh) 膜联蛋白a1 n-末端肽的制剂和方法
US9314497B2 (en) E2F as a target of hormone refractory prostate cancer
TW201014598A (en) Agent for treating pulmonary disease
Nishizawa et al. Highly potent antiobesity effect of a short-length peptide YY analog in mice
KR102780883B1 (ko) 신규한 항염증성 펩타이드 및 이의 용도
JP6697474B2 (ja) 代謝障害の治療薬としてのデルマトポンチン
KR20210147362A (ko) Nlrx1 유래의 신규한 항염증성 펩타이드 및 이의 용도
CN102036678A (zh) 针对脑膜炎的防卫素的用途
WO2005056784A1 (ja) インスリン誘導性ポリペプチド
CN106794225A (zh) 肉豆蔻酰化的瘦素相关肽及其用途
HK40120800A (zh) 用於治疗心源性休克的髓源性生长因子
US20050256040A1 (en) Artificially designed pore-forming proteins with anti-tumor effects
US20210238229A1 (en) Peptide for disease treatment
JP2008517045A (ja) 癌の治療法
JP2004175689A (ja) 癌転移抑制剤
CN107428809A (zh) 一种重组蛋白质药物的分子设计
KR20160127017A (ko) 폐내 염증의 완화

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ENTERIS BIOPHARMA, INC. (US)

B25A Requested transfer of rights approved

Owner name: RESOTHER PHARMA APS (DK)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/06/2012, OBSERVADAS AS CONDICOES LEGAIS.