BR112013029208A2 - método para preparar um ou mais oligossarídeos de leite humano ou derivados ou precursores dos mesmos, uso de oligossacarídeos, e, composto - Google Patents

método para preparar um ou mais oligossarídeos de leite humano ou derivados ou precursores dos mesmos, uso de oligossacarídeos, e, composto

Info

Publication number
BR112013029208A2
BR112013029208A2 BR112013029208A BR112013029208A BR112013029208A2 BR 112013029208 A2 BR112013029208 A2 BR 112013029208A2 BR 112013029208 A BR112013029208 A BR 112013029208A BR 112013029208 A BR112013029208 A BR 112013029208A BR 112013029208 A2 BR112013029208 A2 BR 112013029208A2
Authority
BR
Brazil
Prior art keywords
oligosaccharides
derivatives
preparing
compound
human milk
Prior art date
Application number
BR112013029208A
Other languages
English (en)
Inventor
Schroven Andreas
Champion Elise
Dekany Gyula
Hederos Markus
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/051314 external-priority patent/WO2012127410A1/en
Application filed by Glycom As filed Critical Glycom As
Publication of BR112013029208A2 publication Critical patent/BR112013029208A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0114—Lacto-N-biosidase (3.2.1.140)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Mycology (AREA)
  • Pediatric Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Medicinal Preparation (AREA)
BR112013029208A 2011-05-13 2012-05-14 método para preparar um ou mais oligossarídeos de leite humano ou derivados ou precursores dos mesmos, uso de oligossacarídeos, e, composto BR112013029208A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11166135 2011-05-13
PCT/IB2012/051314 WO2012127410A1 (en) 2011-03-18 2012-03-19 Synthesis of new fucose-containing carbohydrate derivatives
PCT/IB2012/052400 WO2012156897A1 (en) 2011-05-13 2012-05-14 METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF

Publications (1)

Publication Number Publication Date
BR112013029208A2 true BR112013029208A2 (pt) 2017-02-14

Family

ID=47176363

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013029208A BR112013029208A2 (pt) 2011-05-13 2012-05-14 método para preparar um ou mais oligossarídeos de leite humano ou derivados ou precursores dos mesmos, uso de oligossacarídeos, e, composto

Country Status (12)

Country Link
US (1) US9234225B2 (pt)
EP (1) EP2707493A4 (pt)
JP (1) JP2014513985A (pt)
KR (1) KR20140036227A (pt)
CN (1) CN103562401A (pt)
AU (1) AU2012257395A1 (pt)
BR (1) BR112013029208A2 (pt)
CA (1) CA2835986A1 (pt)
IL (1) IL229048A0 (pt)
MX (1) MX2013013028A (pt)
RU (1) RU2013155452A (pt)
WO (1) WO2012156897A1 (pt)

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KR20140001198A (ko) 2010-07-16 2014-01-06 글리콤 에이/에스 신규 시알로올리고당 유도체들의 합성
CA2830025A1 (en) * 2011-03-18 2012-09-27 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
WO2013190529A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products
EP2864344A4 (en) * 2012-06-22 2015-12-23 Glycom As GALACTOSYL GLYCOSYLATED DISACCHARIDES, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN CONSUMABLE PRODUCTS
EP2931737A4 (en) * 2012-12-14 2016-11-16 Glycom As MIXTURE FROM FUCOSYLATE LACTOSES
GB201306689D0 (en) 2013-04-12 2013-05-29 Glycom As Synthesis of sialylated/fucosylated human milk oligosaccharides
US20160113952A1 (en) 2013-05-22 2016-04-28 Glycom As Synthetic Mixture of Oligosaccharides for Treating a Microbiota of a Mammal
US10364449B2 (en) 2013-09-06 2019-07-30 Glycom A/S Fermentative production of oligosaccharides
PL2845905T3 (pl) 2013-09-10 2021-09-27 Chr. Hansen HMO GmbH Wytwarzanie oligosacharydów
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
MY186844A (en) 2014-07-09 2021-08-25 Cadena Bio Inc Oligosaccharide compositions and methods for producing thereof
US10415021B2 (en) 2014-10-24 2019-09-17 Glycom A/S Mutated fucosidase
PL3209673T5 (pl) 2014-10-24 2023-10-23 Glycom A/S Mieszaniny hmo
EP3212197A4 (en) 2014-10-29 2018-07-11 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
ES2856053T3 (es) 2014-10-29 2021-09-27 Glycom As Composición sintética y procedimiento para promover la cicatrización de la mucosa
US10500221B2 (en) * 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
WO2016091265A1 (en) 2014-12-08 2016-06-16 Glycom A/S Synthetic composition for treating metabolic disorders
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
CN112515178A (zh) * 2015-01-26 2021-03-19 卡德纳生物股份有限公司 用于营养组合物的寡糖组合物和其制造方法
PT3354282T (pt) 2015-01-26 2021-03-18 Kaleido Biosciences Inc Produtos terapêuticos de glicanos e seus métodos relacionados
JP6722697B2 (ja) * 2015-01-26 2020-07-15 カデナ・バイオ・インコーポレイテッド 動物飼料として使用するためのオリゴ糖組成物及びその生成方法
CN115300517A (zh) * 2015-03-31 2022-11-08 格礼卡姆股份公司 包含3’-o-唾液乳糖的人乳寡糖的混合物
CA2983236A1 (en) 2015-04-23 2016-10-27 Kaleido Biosciences, Inc. Glycan therapeutics and methods of treatment
PL3307752T3 (pl) 2015-06-09 2021-11-02 Glycom A/S Mieszaniny trójskładnikowe 6’-sl, lnnt i lst c
EP3349763B1 (en) 2015-09-14 2021-08-11 Glycom A/S Composition for use in microbiota modulation
EP3368046B1 (en) 2015-10-28 2022-07-27 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
EP3368047B1 (en) 2015-10-28 2023-04-26 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
WO2017084673A1 (en) 2015-11-17 2017-05-26 Glycom A/S Synthetic Composition for Treating Antibiotic Associated Complications
US10857168B2 (en) 2016-02-24 2020-12-08 Glycom A/S Synthetic composition for microbiota modulation
KR101731263B1 (ko) * 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
WO2017190754A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for the treatment of non-infectious diarrhoea
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
WO2017198276A1 (en) 2016-05-19 2017-11-23 Glycom A/S Synthetic composition
WO2017221208A1 (en) * 2016-06-24 2017-12-28 Glycom A/S Compositions comprising hmos, their production and use for the prevention and/or treatment of viral and/or bacterial infections
WO2018031734A1 (en) * 2016-08-10 2018-02-15 University Of Maryland, College Park DESIGNER α1,6-FUCOSIDASE MUTANTS ENABLE DIRECT CORE FUCOSYLATION OF INTACT N-GLYCOPEPTIDES AND N-GLYCOPROTEINS
US11278558B2 (en) 2017-03-01 2022-03-22 Glycom A/S Synthetic composition for microbiota modulation
US11291677B2 (en) 2017-05-09 2022-04-05 Glycom A/S Synthetic composition for microbiota modulation
EP3630124A4 (en) 2017-05-24 2021-02-24 Glycom A/S SYNTHETIC COMPOSITION CONSISTING OF OLIGOSACCHARIDES AND ITS USE IN MEDICAL TREATMENT
US11541067B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing detrimental proteolytic metabolites
US11142541B2 (en) 2017-06-30 2021-10-12 Glycom A/S Purification of oligosaccharides
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
WO2019087140A1 (en) 2017-11-02 2019-05-09 Glycom A/S One or more hmos for reducing or preventing fatigue and/or improving focus or concentration
JP7327724B2 (ja) 2017-11-30 2023-08-16 グリコム・アクティーゼルスカブ 小麦過敏症を処置するためのｈｍｏの混合物
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
US11304966B2 (en) 2017-12-22 2022-04-19 Glycom A/S Composition comprising HMOs for preventing or reducing nociception
JP2021526143A (ja) 2018-05-31 2021-09-30 グリコム・アクティーゼルスカブＧｌｙｃｏｍ Ａ／Ｓ 自己免疫疾患を処置するためのｈｍｏの混合物
SG11202104207TA (en) * 2018-11-08 2021-05-28 Kaleido Biosciences Inc Oligosaccharide compositions and methods of use thereof
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
EP3670662A1 (en) 2018-12-20 2020-06-24 Basf Se Enzymatic hexosaminidation of lactose
CN110483652A (zh) * 2019-06-11 2019-11-22 中国农业大学 一种人乳寡糖及其在制备用于通过缓解肠道缺氧损伤而治疗或预防nec的药物中的用途
CN114350640B (zh) * 2019-12-13 2023-09-08 中国科学院天津工业生物技术研究所 一株表达几丁质酶重组菌的构建及高酶活突变体的筛选
CN116249781A (zh) * 2020-08-10 2023-06-09 因比奥斯公司 在细胞中的含有GlcNAc的生物产品的产生
CN112795583A (zh) * 2020-11-16 2021-05-14 上海大学 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法
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Also Published As

Publication number Publication date
JP2014513985A (ja) 2014-06-19
MX2013013028A (es) 2013-12-02
IL229048A0 (en) 2013-12-31
EP2707493A1 (en) 2014-03-19
US9234225B2 (en) 2016-01-12
EP2707493A4 (en) 2014-10-08
WO2012156897A1 (en) 2012-11-22
AU2012257395A1 (en) 2013-12-12
US20140234912A1 (en) 2014-08-21
RU2013155452A (ru) 2015-06-20
CA2835986A1 (en) 2012-11-22
CN103562401A (zh) 2014-02-05
KR20140036227A (ko) 2014-03-25

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