BR112013020015A2 - (5s,8s)-3-(4'-cloro-3'-flúor-4-metilbifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-ona (composto a) para terapia - Google Patents

(5s,8s)-3-(4'-cloro-3'-flúor-4-metilbifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-ona (composto a) para terapia

Info

Publication number
BR112013020015A2
BR112013020015A2 BR112013020015A BR112013020015A BR112013020015A2 BR 112013020015 A2 BR112013020015 A2 BR 112013020015A2 BR 112013020015 A BR112013020015 A BR 112013020015A BR 112013020015 A BR112013020015 A BR 112013020015A BR 112013020015 A2 BR112013020015 A2 BR 112013020015A2
Authority
BR
Brazil
Prior art keywords
methylbiphenyl
azaspiro
fluoro
chloro
methoxy
Prior art date
Application number
BR112013020015A
Other languages
English (en)
Inventor
Scholz Arne
Hilger Christoph-Stephan
Thede Kai
Eis Knut
Najjar Maher
Liu Ningshu
Lienau Philip
Fischer Reiner
Bömer Ulf
Ahmed Moradi Wahed
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102011011040A external-priority patent/DE102011011040A1/de
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of BR112013020015A2 publication Critical patent/BR112013020015A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR112013020015A 2011-02-06 2012-02-03 (5s,8s)-3-(4'-cloro-3'-flúor-4-metilbifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-ona (composto a) para terapia BR112013020015A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KW1411 2011-02-06
DE102011011040A DE102011011040A1 (de) 2011-02-08 2011-02-08 (5s,8s)-3-(4'-Chlor-3'-fluor-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-on (Verbindung A) zur Therapie
PCT/EP2012/051895 WO2012104428A1 (de) 2011-02-06 2012-02-03 (5s,8s)-3-(4'-chlor-3'-fluor-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-on (verbindung a) zur therapie

Publications (1)

Publication Number Publication Date
BR112013020015A2 true BR112013020015A2 (pt) 2017-03-21

Family

ID=49485835

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013020015A BR112013020015A2 (pt) 2011-02-06 2012-02-03 (5s,8s)-3-(4'-cloro-3'-flúor-4-metilbifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-ona (composto a) para terapia

Country Status (18)

Country Link
US (1) US9212140B2 (pt)
EP (1) EP2670408A1 (pt)
JP (1) JP2014504624A (pt)
KR (1) KR20140053844A (pt)
CN (1) CN103533932A (pt)
AP (1) AP2013007057A0 (pt)
AR (1) AR085146A1 (pt)
AU (1) AU2012213344A1 (pt)
BR (1) BR112013020015A2 (pt)
CA (1) CA2826515A1 (pt)
CL (1) CL2013002247A1 (pt)
EA (1) EA201391084A1 (pt)
IL (1) IL227804A0 (pt)
MA (1) MA34887B1 (pt)
MX (1) MX2013009065A (pt)
TN (1) TN2013000336A1 (pt)
TW (1) TW201240659A (pt)
WO (1) WO2012104428A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2923884A1 (en) 2013-09-12 2015-03-19 Pfizer Inc. Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9507275A (pt) * 1994-04-05 1997-11-18 Bayer Ag 1h-3-aril-pirrolidina-2,4-dionas alcoxi-alquil-substituídas
DE19813354A1 (de) * 1998-03-26 1999-09-30 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
DE10201239A1 (de) * 2002-01-15 2003-07-24 Bayer Cropscience Ag Fungizide biphenylsubstituierte cyclische Ketoenole
DE102006057037A1 (de) * 2006-12-04 2008-06-05 Bayer Cropscience Ag cis-Alkoxyspirocyclische biphenylsubstituierte Tetramsäure-Derivate
UY31968A (es) * 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
DE102010008644A1 (de) * 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie

Also Published As

Publication number Publication date
KR20140053844A (ko) 2014-05-08
TW201240659A (en) 2012-10-16
MA34887B1 (fr) 2014-02-01
EP2670408A1 (de) 2013-12-11
AU2012213344A1 (en) 2013-08-22
CN103533932A (zh) 2014-01-22
CL2013002247A1 (es) 2014-01-03
EA201391084A1 (ru) 2014-02-28
US9212140B2 (en) 2015-12-15
AP2013007057A0 (en) 2013-08-31
CA2826515A1 (en) 2012-08-09
JP2014504624A (ja) 2014-02-24
TN2013000336A1 (en) 2015-01-20
AR085146A1 (es) 2013-09-11
MX2013009065A (es) 2013-10-01
US20140031407A1 (en) 2014-01-30
WO2012104428A1 (de) 2012-08-09
IL227804A0 (en) 2013-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]