BR112013013016A2 - modulação de imunogenicidade de antígeno pela eliminação de epítopos reconhecidos pelas células nkt14 - Google Patents
modulação de imunogenicidade de antígeno pela eliminação de epítopos reconhecidos pelas células nkt14Info
- Publication number
- BR112013013016A2 BR112013013016A2 BR112013013016A BR112013013016A BR112013013016A2 BR 112013013016 A2 BR112013013016 A2 BR 112013013016A2 BR 112013013016 A BR112013013016 A BR 112013013016A BR 112013013016 A BR112013013016 A BR 112013013016A BR 112013013016 A2 BR112013013016 A2 BR 112013013016A2
- Authority
- BR
- Brazil
- Prior art keywords
- nkt14
- elimination
- modulation
- cells
- epitopes recognized
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 230000008030 elimination Effects 0.000 title abstract 2
- 238000003379 elimination reaction Methods 0.000 title abstract 2
- 230000005847 immunogenicity Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 235000003869 genetically modified organism Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/641—Cysteine endopeptidases (3.4.22)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Insects & Arthropods (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
modulação de imunogenicidade de antígeno pela eliminação de epítopos reconhecidos pelas células nkt14. a presente invenção refere-se a um método e compostos para a prevenção de respostas imunológicas direcionadas a alofatores, direcionadas a vetores virais usados para terapia genética e vacinação genética, direcionadas e proteínas às quais os pacientes são naturalmente expostos, direcionadas a organismos geneticamente modificados e direcionadas a efeitos indesejáveis relacionados com a administração de vacinas para doenças alérgicas ou infecciosas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10192568 | 2010-11-25 | ||
EP10192568.3 | 2010-11-25 | ||
PCT/EP2011/070911 WO2012069575A1 (en) | 2010-11-25 | 2011-11-24 | Modulation of antigen immunogenicity by deleting epitopes recognized by nkt cells |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013013016A2 true BR112013013016A2 (pt) | 2016-09-13 |
BR112013013016B1 BR112013013016B1 (pt) | 2021-12-14 |
Family
ID=43798355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013013016-4A BR112013013016B1 (pt) | 2010-11-25 | 2011-11-24 | Método para obter um peptídeo ou um polipeptídeo isolado com a capacidade reduzida de ativar células nkt e polipeptídeo isolado |
Country Status (11)
Country | Link |
---|---|
US (3) | US9732118B2 (pt) |
EP (1) | EP2643347B1 (pt) |
JP (1) | JP2014501727A (pt) |
CN (1) | CN103596971B (pt) |
AU (1) | AU2011333756B2 (pt) |
BR (1) | BR112013013016B1 (pt) |
CA (1) | CA2819182C (pt) |
DK (1) | DK2643347T3 (pt) |
ES (1) | ES2663862T3 (pt) |
RU (1) | RU2598247C2 (pt) |
WO (1) | WO2012069575A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2666782A1 (en) * | 2012-05-22 | 2013-11-27 | Imnate Sarl | Coagulation factor VIII with reduced immunogenicity. |
WO2015077709A2 (en) * | 2013-11-22 | 2015-05-28 | World Biotechnology LLC | Method for harvesting organic compounds from genetically modified organisms |
AU2016257196B2 (en) * | 2015-05-04 | 2021-11-25 | Vcn Biosciences Sl | Oncolytic adenoviruses with mutations in immunodominant adenovirus epitopes and their use in cancer treatment |
EP3388447A1 (en) * | 2017-04-14 | 2018-10-17 | Imnate Sarl | Methods to produce peptides, polypeptides or cells for modulating immunity |
EP3756648A1 (en) | 2019-06-27 | 2020-12-30 | Imnate Sarl | Improved vaccine formulations |
EP3936867A1 (en) | 2020-07-06 | 2022-01-12 | Imnate Sarl | Cd1 peptide-epitope for use in the treatment of a disease caused by an intracellular pathogen |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001292610A1 (en) * | 2000-09-08 | 2002-03-22 | University Of Maryland Biotechnology Institute | Genetically engineered co-expression dna vaccines, construction methods and uses thereof |
US7084257B2 (en) * | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
GB0605247D0 (en) * | 2006-03-15 | 2006-04-26 | Chiron Srl | Compositions and methods for immunisation |
WO2010037395A2 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
US20110256147A1 (en) * | 2008-12-01 | 2011-10-20 | The Johns Hopkins University | Diagnostic and treatment methods for cancer based on immune inhibitors |
US8691211B2 (en) * | 2009-03-10 | 2014-04-08 | Puget Sound Blood Center | Suppression of immune response to factor VIII in hemophilia A patients |
-
2011
- 2011-11-24 AU AU2011333756A patent/AU2011333756B2/en active Active
- 2011-11-24 DK DK11788142.5T patent/DK2643347T3/en active
- 2011-11-24 JP JP2013540357A patent/JP2014501727A/ja active Pending
- 2011-11-24 RU RU2013128741/10A patent/RU2598247C2/ru active
- 2011-11-24 CN CN201180064053.4A patent/CN103596971B/zh active Active
- 2011-11-24 BR BR112013013016-4A patent/BR112013013016B1/pt active IP Right Grant
- 2011-11-24 US US13/989,352 patent/US9732118B2/en active Active
- 2011-11-24 CA CA2819182A patent/CA2819182C/en active Active
- 2011-11-24 EP EP11788142.5A patent/EP2643347B1/en active Active
- 2011-11-24 WO PCT/EP2011/070911 patent/WO2012069575A1/en active Application Filing
- 2011-11-24 ES ES11788142.5T patent/ES2663862T3/es active Active
-
2017
- 2017-07-14 US US15/650,784 patent/US11091512B2/en active Active
-
2021
- 2021-07-30 US US17/390,702 patent/US20210355162A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2014501727A (ja) | 2014-01-23 |
AU2011333756A1 (en) | 2013-06-13 |
US20180009843A1 (en) | 2018-01-11 |
CN103596971B (zh) | 2016-10-12 |
US20210355162A1 (en) | 2021-11-18 |
US9732118B2 (en) | 2017-08-15 |
AU2011333756B2 (en) | 2017-06-15 |
CN103596971A (zh) | 2014-02-19 |
EP2643347A1 (en) | 2013-10-02 |
BR112013013016B1 (pt) | 2021-12-14 |
ES2663862T3 (es) | 2018-04-17 |
WO2012069575A1 (en) | 2012-05-31 |
CA2819182C (en) | 2021-06-29 |
EP2643347B1 (en) | 2017-12-27 |
DK2643347T3 (en) | 2018-03-26 |
RU2013128741A (ru) | 2014-12-27 |
CA2819182A1 (en) | 2012-05-31 |
US11091512B2 (en) | 2021-08-17 |
US20130280284A1 (en) | 2013-10-24 |
RU2598247C2 (ru) | 2016-09-20 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |