BR112013008816A2 - método de tratamento de câncer direcionado ao egfr resistente à erlotinibe ou gefitinibe, ou uso de um sal farmacêuticamente aceito em um indivíduo - Google Patents
método de tratamento de câncer direcionado ao egfr resistente à erlotinibe ou gefitinibe, ou uso de um sal farmacêuticamente aceito em um indivíduoInfo
- Publication number
- BR112013008816A2 BR112013008816A2 BR112013008816A BR112013008816A BR112013008816A2 BR 112013008816 A2 BR112013008816 A2 BR 112013008816A2 BR 112013008816 A BR112013008816 A BR 112013008816A BR 112013008816 A BR112013008816 A BR 112013008816A BR 112013008816 A2 BR112013008816 A2 BR 112013008816A2
- Authority
- BR
- Brazil
- Prior art keywords
- erlotinib
- individual
- pharmaceutically acceptable
- acceptable salt
- cancer targeted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39329110P | 2010-10-14 | 2010-10-14 | |
| PCT/US2011/056457 WO2012051587A1 (en) | 2010-10-14 | 2011-10-14 | Methods for inhibiting cell proliferation in egfr-driven cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013008816A2 true BR112013008816A2 (pt) | 2016-06-28 |
Family
ID=45938740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013008816A BR112013008816A2 (pt) | 2010-10-14 | 2011-10-14 | método de tratamento de câncer direcionado ao egfr resistente à erlotinibe ou gefitinibe, ou uso de um sal farmacêuticamente aceito em um indivíduo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140024620A1 (https=) |
| EP (1) | EP2627179A4 (https=) |
| JP (1) | JP2013539795A (https=) |
| KR (1) | KR20130139999A (https=) |
| CN (2) | CN103153064B (https=) |
| AU (1) | AU2011315831B2 (https=) |
| BR (1) | BR112013008816A2 (https=) |
| CA (1) | CA2810900A1 (https=) |
| EA (1) | EA201390550A1 (https=) |
| IL (1) | IL225351A0 (https=) |
| MX (1) | MX2013004086A (https=) |
| WO (1) | WO2012051587A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| EP2844642B8 (en) * | 2012-05-05 | 2019-12-25 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| CN102977104A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 2,4-二氯-7-氢-吡咯并（2,3）嘧啶的合成 |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| UA115388C2 (uk) * | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| CN104761544B (zh) * | 2014-01-03 | 2019-03-15 | 北京轩义医药科技有限公司 | Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 |
| US10300058B2 (en) | 2014-04-18 | 2019-05-28 | Xuanzhu Pharma Co., Ltd. | Tyrosine kinase inhibitor and uses thereof |
| US10053477B2 (en) * | 2014-07-04 | 2018-08-21 | Qilu Pharmaceutical Co., Ltd. | Spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide |
| CN106699810A (zh) * | 2015-11-17 | 2017-05-24 | 清华大学 | 一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用 |
| EP3381925B1 (en) * | 2015-11-27 | 2020-12-16 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Deuterium-modified brigatinib derivatives, pharmaceutical compositions comprising same, and use thereof |
| CN109071512A (zh) * | 2016-02-03 | 2018-12-21 | 重庆复创医药研究有限公司 | 作为激酶抑制剂的含磷化合物 |
| CN107098887B (zh) * | 2016-02-22 | 2019-08-09 | 复旦大学 | 嘧啶类化合物 |
| EP3453392B1 (en) | 2016-05-17 | 2025-10-22 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired egfr-tki resistance |
| EP3504203B1 (en) | 2016-08-29 | 2022-09-28 | The Regents of The University of Michigan | Aminopyrimidines as alk inhibitors |
| US11180482B2 (en) * | 2016-11-30 | 2021-11-23 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors |
| CN110520110A (zh) * | 2017-03-08 | 2019-11-29 | 阿瑞雅德制药公司 | 包含5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的药物制剂 |
| PH12020550034B1 (en) * | 2017-07-19 | 2024-05-22 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Aryl-phosphorus-oxygen compound as egfr kinase inhibitor |
| SG11202002060XA (en) * | 2017-09-08 | 2020-04-29 | Univ Colorado Regents | Compounds, compositions and methods for treating or preventing her-driven drug-resistant cancers |
| JP7043098B2 (ja) * | 2017-12-21 | 2022-03-29 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジアニリノピリミジン系化合物 |
| CN110305161A (zh) * | 2018-03-20 | 2019-10-08 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| CN110467638A (zh) * | 2018-05-09 | 2019-11-19 | 北京赛特明强医药科技有限公司 | 一种含有间氯苯胺类取代基的双氨基氯代嘧啶类化合物、制备方法及其应用 |
| CN110467637B (zh) * | 2018-05-09 | 2022-02-18 | 北京赛特明强医药科技有限公司 | 一种含有氧化膦类取代苯胺的双氨基氯代嘧啶类化合物、制备方法及其应用 |
| CN110526941A (zh) * | 2018-05-24 | 2019-12-03 | 北京赛特明强医药科技有限公司 | 一种含有间氯苯胺类取代基的吡咯并嘧啶类化合物、制备方法及其应用 |
| CN111836819A (zh) * | 2018-05-24 | 2020-10-27 | 北京赛特明强医药科技有限公司 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
| CN110835320B (zh) * | 2018-08-15 | 2025-12-30 | 江苏奥赛康药业有限公司 | 二氨基嘧啶类化合物及其应用 |
| JP2022517396A (ja) * | 2019-01-18 | 2022-03-08 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Ｅｇｆｒ阻害剤の塩、結晶形及びその製造方法 |
| CN111825719A (zh) * | 2019-04-15 | 2020-10-27 | 北京赛特明强医药科技有限公司 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
| CN113166103B (zh) * | 2019-04-26 | 2022-12-16 | 江苏先声药业有限公司 | Egfr抑制剂及其应用 |
| CN112513029B (zh) * | 2019-06-21 | 2023-10-24 | 上海翰森生物医药科技有限公司 | 含氮芳基磷氧化物类衍生物、其制备方法和应用 |
| JP2022539208A (ja) | 2019-07-03 | 2022-09-07 | スミトモ ファーマ オンコロジー， インコーポレイテッド | チロシンキナーゼ非受容体１（ｔｎｋ１）阻害剤およびその使用 |
| CN114430739A (zh) * | 2019-07-26 | 2022-05-03 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| WO2021018003A1 (zh) * | 2019-07-26 | 2021-02-04 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| CN112538072B (zh) * | 2019-09-21 | 2024-02-06 | 齐鲁制药有限公司 | 氨基嘧啶类egfr抑制剂 |
| CN114502564A (zh) * | 2019-09-26 | 2022-05-13 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| CN114430741A (zh) * | 2019-10-17 | 2022-05-03 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| AU2020385527B2 (en) * | 2019-11-21 | 2023-04-13 | Tyk Medicines, Inc. | Compound used as EGFR kinase inhibitor and use thereof |
| CN114728932B (zh) * | 2019-11-29 | 2024-11-29 | 江苏先声药业有限公司 | 作为egfr激酶抑制剂的多芳基化合物 |
| WO2021160087A1 (zh) * | 2020-02-14 | 2021-08-19 | 贝达药业股份有限公司 | 喹啉基膦氧化合物及其组合物和用途 |
| AU2021227907A1 (en) * | 2020-02-25 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Potent and selective degraders of ALK |
| EP4129996A4 (en) * | 2020-03-23 | 2023-07-12 | Qilu Pharmaceutical Co., Ltd. | Novel aminopyrimidine egfr inhibitor |
| CN111777592B (zh) * | 2020-06-22 | 2021-06-18 | 温州医科大学 | 一种n4-(2,5-二甲氧基苯基)-嘧啶二胺类靶向ddr1抑制剂及其制备和应用 |
| CA3196857A1 (en) * | 2020-10-30 | 2022-05-05 | Gurulingappa Hallur | Pyrimidine compounds, compositions, and medicinal applications thereof |
| CN116710444A (zh) * | 2020-10-30 | 2023-09-05 | 缆图药品公司 | 嘧啶化合物、组合物及其医药应用 |
| CN116685583A (zh) * | 2020-10-30 | 2023-09-01 | 缆图药品公司 | 嘧啶化合物、组合物及其医药应用 |
| PE20231515A1 (es) * | 2020-10-30 | 2023-09-28 | Blueprint Medicines Corp | Compuestos de pirimidina, composiciones y aplicaciones medicas de esta |
| WO2022127807A1 (zh) * | 2020-12-18 | 2022-06-23 | 江苏豪森药业集团有限公司 | 一种芳基磷氧化物类衍生物自由碱的晶型及其制备方法和应用 |
| AU2022205713A1 (en) * | 2021-01-07 | 2023-07-27 | Ontario Institute For Cancer Research (Oicr) | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof |
| WO2022147622A1 (en) * | 2021-01-07 | 2022-07-14 | Ontario Institute For Cancer Research (Oicr) | Isoindolinone aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof |
| TW202237597A (zh) * | 2021-03-19 | 2022-10-01 | 大陸商上海齊魯製藥研究中心有限公司 | 新型egfr降解劑 |
| WO2022199589A1 (zh) * | 2021-03-23 | 2022-09-29 | 南京明德新药研发有限公司 | 嘧啶衍生物 |
| BR112023019370A2 (pt) * | 2021-04-01 | 2023-12-26 | Univ Yonsei Iacf | Composto, e, composição farmacêutica para prevenir, melhorar ou tratar câncer |
| WO2022228556A1 (en) * | 2021-04-30 | 2022-11-03 | Beigene, Ltd. | Egfr degraders and associated methods of use |
| WO2022227032A1 (en) * | 2021-04-30 | 2022-11-03 | Beigene (Beijing) Co., Ltd. | Egfr degraders and associated methods of use |
| WO2023006088A1 (zh) * | 2021-07-30 | 2023-02-02 | 浙江大学智能创新药物研究院 | 一种用于egfr激酶抑制剂的化合物、组合物及其应用 |
| WO2024005516A1 (ko) * | 2022-06-28 | 2024-01-04 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
| CN115260234A (zh) * | 2022-07-01 | 2022-11-01 | 江苏医药职业学院 | 一种2-氨基-4-氨基芳基磷氧基嘧啶化合物及其制备方法与应用 |
| CN116284001B (zh) * | 2023-01-30 | 2025-06-06 | 中国药科大学 | Dclk1抑制剂、制备方法、药物组合物和应用 |
| CN117187271B (zh) * | 2023-03-07 | 2024-08-27 | 艾博生物科技(上海)有限公司 | 编码激活性EGFR突变肽的免疫调节治疗mRNA组合物 |
| CN121319053A (zh) * | 2024-07-10 | 2026-01-13 | 中国科学院基础医学与肿瘤研究所(筹) | 一类带有二乙烯基磷酰基的2-氨基嘧啶类化合物及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343782B1 (en) * | 2000-12-21 | 2009-05-06 | SmithKline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
| JP2009514876A (ja) * | 2005-11-03 | 2009-04-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼのための化合物および組成物 |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| WO2008039359A2 (en) * | 2006-09-25 | 2008-04-03 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidine kinase inhibitors |
| TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| US7989465B2 (en) * | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
| MX2010009743A (es) * | 2008-03-05 | 2010-09-28 | Novartis Ag | Uso de derivados de pirimidina para el tratamiento de las enfermedades dependientes de los receptores del factor de crecimiento epidermico (egfr) o de enfermedades que hayan adquirido resistencia a los agentes que se dirigen a los miembros de la fami |
| US8592432B2 (en) * | 2008-04-07 | 2013-11-26 | Bei Chen | Compounds and compositions as protein kinase inhibitors |
| PT2300013T (pt) * | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| TWI546290B (zh) * | 2008-06-27 | 2016-08-21 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
| PT2585470T (pt) * | 2010-06-23 | 2017-03-06 | Hanmi Science Co Ltd | Novos derivados fundidos de pirimidina para inibição da actividade da tirosina cinase |
| EP2635285B1 (en) * | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| JP5957003B2 (ja) * | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | 変異体選択的ｅｇｆｒ阻害剤およびその使用 |
-
2011
- 2011-10-14 BR BR112013008816A patent/BR112013008816A2/pt not_active IP Right Cessation
- 2011-10-14 MX MX2013004086A patent/MX2013004086A/es not_active Application Discontinuation
- 2011-10-14 CN CN201180049813.4A patent/CN103153064B/zh active Active
- 2011-10-14 EA EA201390550A patent/EA201390550A1/ru unknown
- 2011-10-14 KR KR1020137012320A patent/KR20130139999A/ko not_active Withdrawn
- 2011-10-14 EP EP11833524.9A patent/EP2627179A4/en not_active Withdrawn
- 2011-10-14 US US13/878,744 patent/US20140024620A1/en not_active Abandoned
- 2011-10-14 CN CN201510102987.2A patent/CN104814970A/zh active Pending
- 2011-10-14 WO PCT/US2011/056457 patent/WO2012051587A1/en not_active Ceased
- 2011-10-14 JP JP2013534053A patent/JP2013539795A/ja active Pending
- 2011-10-14 AU AU2011315831A patent/AU2011315831B2/en active Active
- 2011-10-14 CA CA2810900A patent/CA2810900A1/en not_active Abandoned
-
2013
- 2013-03-20 IL IL225351A patent/IL225351A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2627179A1 (en) | 2013-08-21 |
| CN103153064B (zh) | 2015-04-22 |
| AU2011315831B2 (en) | 2015-01-22 |
| EP2627179A4 (en) | 2014-04-02 |
| US20140024620A1 (en) | 2014-01-23 |
| JP2013539795A (ja) | 2013-10-28 |
| CN104814970A (zh) | 2015-08-05 |
| EA201390550A1 (ru) | 2013-08-30 |
| AU2011315831A1 (en) | 2013-03-28 |
| WO2012051587A1 (en) | 2012-04-19 |
| CN103153064A (zh) | 2013-06-12 |
| CA2810900A1 (en) | 2012-04-19 |
| KR20130139999A (ko) | 2013-12-23 |
| MX2013004086A (es) | 2013-07-05 |
| IL225351A0 (en) | 2013-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013008816A2 (pt) | método de tratamento de câncer direcionado ao egfr resistente à erlotinibe ou gefitinibe, ou uso de um sal farmacêuticamente aceito em um indivíduo | |
| BR112013023277A2 (pt) | métodos de tratamento de câncer usando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidibna-2,6-diona | |
| BR112014007603A2 (pt) | métodos de tratamento do câncer | |
| IL257330B (en) | Compositions, methods and kits for diagnosis of lung cancer | |
| IL242284A (en) | Annals 2– (2, 4, 5 – Inilino – Converted) as egfr modulators for cancer treatment | |
| IL228741A0 (en) | A method for egfr-targeted combined cancer therapy | |
| BR112012001395A2 (pt) | metodo para tratar um câncer her2 positivo em um mamifero metodo para aumentar os efetivos de antagonistas do receptor her2 em um mamifero apresentando um cancêr her2 positivo metodo para inibir o crescimento ou proliferação de células her2 positivas em um mamifero | |
| PT2897620T (pt) | Método de tratamento de cancro | |
| BR112014000235A2 (pt) | emulsões de óleo em água catiônicas | |
| BR112013025353A8 (pt) | combinação de a) um composto de fórmula ia, composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, método para tratamento de um distúrbio hiperproliferativo em um mamífero, uso de um composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, kit e produto | |
| EP2697397A4 (en) | SAFE SORTING SYSTEM | |
| EP2768385A4 (en) | METHOD AND SYSTEM FOR DIRECT COMMUNICATION | |
| DK2681227T3 (da) | Phosphoramidatderivater af 5-fluor-2'-deoxyuridin til anvendelse i behandlingen af cancer | |
| EP3821941C0 (en) | NEURAL STIMULATOR SYSTEM | |
| BRPI1008396A2 (pt) | sal de tosilato de um derivado de 5-pirazolil-2-piridona, útil no tratamento de copd | |
| LT3026064T (lt) | Antikūnai, skirti vėžio gydymui, ekspresuojantys klaudiną 6 | |
| ZA201403548B (en) | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy | |
| IL235459A0 (en) | Ways to treat non-small cell lung cancer | |
| BR112013011659A2 (pt) | métodos de tratamento do câncer | |
| ZA201309254B (en) | Method for treating non-small cell lung cancer | |
| SI2729173T1 (sl) | Terapija, ki cilja na EGFR | |
| HUE037382T2 (hu) | Eljárás rák kezelésére targeting NQOl alkalmazásával | |
| BR302012001936S1 (pt) | "configuração aplicada em ponteira de escapamento" | |
| PL2754441T3 (pl) | Kompozycja do profilaktyki i leczenia niedrobnokomórkowego raka płuc, zawierająca pochodne pirazyno-triazynowe | |
| WO2013152186A8 (en) | Methods and compositions for 6-phosphogluconate dehydrogenase (6-pgd) as a target for lung cancer therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |