BR112013000962B1 - Compósito de polímero - Google Patents
Compósito de polímero Download PDFInfo
- Publication number
- BR112013000962B1 BR112013000962B1 BR112013000962-4A BR112013000962A BR112013000962B1 BR 112013000962 B1 BR112013000962 B1 BR 112013000962B1 BR 112013000962 A BR112013000962 A BR 112013000962A BR 112013000962 B1 BR112013000962 B1 BR 112013000962B1
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- Prior art keywords
- reinforcement
- polymer composite
- polymer
- composites
- weight
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- 229920000642 polymer Polymers 0.000 title claims abstract description 142
- 239000002131 composite material Substances 0.000 title claims abstract description 132
- 239000000945 filler Substances 0.000 claims abstract description 153
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- 239000001506 calcium phosphate Substances 0.000 claims abstract description 21
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 21
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 18
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 4
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 38
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- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 claims description 10
- AMFGWXWBFGVCKG-UHFFFAOYSA-N Panavia opaque Chemical compound C1=CC(OCC(O)COC(=O)C(=C)C)=CC=C1C(C)(C)C1=CC=C(OCC(O)COC(=O)C(C)=C)C=C1 AMFGWXWBFGVCKG-UHFFFAOYSA-N 0.000 claims description 10
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 108
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- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 6
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- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C—CHEMISTRY; METALLURGY
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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| US20140194363A1 (en) * | 2013-01-08 | 2014-07-10 | Beijing Allgens Medical and Technology Co, Ltd | Compression-resistant collagen-based artificial bone repair material |
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| JP2017048121A (ja) * | 2015-08-31 | 2017-03-09 | 三井化学株式会社 | 歯科用組成物、歯科用ミルブランク、歯科部材及びその製造方法、義歯床及びその製造方法、並びに、有床義歯及びその製造方法 |
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| JP6971225B2 (ja) * | 2016-05-19 | 2021-11-24 | クラレノリタケデンタル株式会社 | 歯科用樹脂組成物 |
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| CN106668945A (zh) * | 2016-12-30 | 2017-05-17 | 宁波诺丁汉大学 | 一种椎间融合器及其制备方法 |
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| CN110885071B (zh) * | 2019-12-17 | 2021-07-09 | 衢州学院 | 一种微米级超长钙基蠕虫状胶束模板及羟基钙磷灰石晶须 |
| CN112451753B (zh) * | 2021-01-28 | 2021-04-27 | 北京天星博迈迪医疗器械有限公司 | 一种纳米纤维增强可吸收骨内固定材料及其制备方法 |
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| DE60033692T2 (de) | 1999-12-07 | 2007-11-08 | William Marsh Rice University, Houston | Orientierte, in eine Polymer-Matrix eingebettete Nanofasern |
| US7758882B2 (en) * | 2000-01-31 | 2010-07-20 | Indiana University Research And Technology Corporation | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
| WO2002033004A1 (fr) * | 2000-10-16 | 2002-04-25 | Asahi Kasei Kabushiki Kaisha | Composition de resine renforcee par une apatite |
| JP2003169845A (ja) | 2001-12-07 | 2003-06-17 | Japan Science & Technology Corp | スポンジ状多孔質アパタイト・コラーゲン複合体、スポンジ状超多孔質アパタイト・コラーゲン複合体及びそれらの製造方法 |
| US7972616B2 (en) * | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| JP4463719B2 (ja) * | 2004-04-22 | 2010-05-19 | 日本特殊陶業株式会社 | 有機−無機複合多孔体、繊維状有機物の製造方法、及び有機−無機複合多孔体の製造方法 |
| US20050255779A1 (en) | 2004-04-22 | 2005-11-17 | Ngk Spark Plug Co., Ltd. | Organic-inorganic composite porous material, method for producing fibrous organic material, and method for producing organic-inorganic composite porous material |
| FI20055194L (fi) * | 2005-04-27 | 2006-10-28 | Bioretec Oy | Bioabsorboituva ja bioaktiivinen komposiittimateriaali ja menetelmä komposiitin valmistamiseksi |
| CA2609390A1 (en) * | 2005-05-26 | 2006-11-30 | Zimmer Dental, Inc. | Prosthetic dental device |
| US20090060961A1 (en) * | 2005-08-10 | 2009-03-05 | Toray Industries Inc. | Spongelike Structure and Powder, As Well As Process for Producing the Same |
| FI20065465A0 (fi) * | 2006-06-30 | 2006-06-30 | Stichtech Oy | Kuitulujitetut komposiitit ja menetelmä niiden valmistamiseksi |
| FI124017B (fi) * | 2006-06-30 | 2014-01-31 | Stick Tech Oy | Kovettavat kuitulujitetut komposiitit ja menetelmä aplikaatio-orientuneiden kuitulujitettujen komposiittien valmistamiseksi |
| CN100469738C (zh) * | 2007-01-22 | 2009-03-18 | 浙江大学 | 石材和石质文物的磷酸钙生物矿化加固方法 |
| CN101687384A (zh) | 2007-03-26 | 2010-03-31 | 康涅狄格大学 | 静电纺丝磷灰石/聚合物纳米复合支架 |
| EP2182886A4 (en) * | 2007-07-12 | 2012-05-30 | Univ North Carolina | FORMABLE BIOKERAMIC MATERIALS |
| EP2163235A1 (de) * | 2008-09-15 | 2010-03-17 | Ivoclar Vivadent AG | Dentalmaterialien mit hohem Biegemodul |
| BR112013000962B1 (pt) * | 2010-07-14 | 2020-06-23 | The Curators Of The University Of Missouri | Compósito de polímero |
-
2011
- 2011-07-14 BR BR112013000962-4A patent/BR112013000962B1/pt active IP Right Grant
- 2011-07-14 US US13/183,221 patent/US9976011B2/en active Active
- 2011-07-14 WO PCT/US2011/044040 patent/WO2012009555A2/en not_active Ceased
- 2011-07-14 DE DE112011101920T patent/DE112011101920T5/de active Pending
- 2011-07-14 CN CN2011800433500A patent/CN103096840A/zh active Pending
- 2011-07-14 JP JP2013519833A patent/JP2013535532A/ja active Pending
- 2011-07-14 CN CN201710990909.XA patent/CN107778528B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2018149346A (ja) | 2018-09-27 |
| CN107778528B (zh) | 2021-06-15 |
| US9976011B2 (en) | 2018-05-22 |
| JP2017048393A (ja) | 2017-03-09 |
| WO2012009555A2 (en) | 2012-01-19 |
| WO2012009555A3 (en) | 2012-03-29 |
| CN107778528A (zh) | 2018-03-09 |
| JP2013535532A (ja) | 2013-09-12 |
| BR112013000962A2 (pt) | 2016-05-17 |
| DE112011101920T5 (de) | 2013-05-02 |
| CN103096840A (zh) | 2013-05-08 |
| US20120129970A1 (en) | 2012-05-24 |
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