BR112012025172A2 - células de ilhotas gabaritadas e agrupamentos de células de ilhotas pequenas para tratamento de diabetes. - Google Patents

células de ilhotas gabaritadas e agrupamentos de células de ilhotas pequenas para tratamento de diabetes.

Info

Publication number
BR112012025172A2
BR112012025172A2 BR112012025172A BR112012025172A BR112012025172A2 BR 112012025172 A2 BR112012025172 A2 BR 112012025172A2 BR 112012025172 A BR112012025172 A BR 112012025172A BR 112012025172 A BR112012025172 A BR 112012025172A BR 112012025172 A2 BR112012025172 A2 BR 112012025172A2
Authority
BR
Brazil
Prior art keywords
islet
cell clusters
templateed
small
treating diabetes
Prior art date
Application number
BR112012025172A
Other languages
English (en)
Other versions
BR112012025172B1 (pt
Inventor
Berkland Cory
Ramachandran Karthik
A Stehno Bittel Lisa
Siahaan Teruna
Original Assignee
Univ Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas filed Critical Univ Kansas
Publication of BR112012025172A2 publication Critical patent/BR112012025172A2/pt
Publication of BR112012025172B1 publication Critical patent/BR112012025172B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)

Abstract

células de ilhotas gabaritadas e agrupamentos de células de ilhotas pequenas para tratamento de diabetes. um andaime tendo células ilhotas ou agrupamentos de células de ilhotas pequenas fixados ao mesmo em uma camada múltipla e um molde tendo tufos para cultivar ilhotas, em que a formação de ilhotas é influenciada pela forma e pelas dimensões dos tufos, são divulgados.
BR112012025172A 2010-04-06 2011-03-31 células de ilhotas gabaritadas e agrupamentos de células de ilhotas pequenas para tratamento de diabetes. BR112012025172B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/798,529 US8735154B2 (en) 2006-10-30 2010-04-06 Templated islet cells and small islet cell clusters for diabetes treatment
PCT/US2011/030775 WO2011126921A2 (en) 2010-04-06 2011-03-31 Templated islet cells and small islet cell clusters for diabetes treatment

Publications (2)

Publication Number Publication Date
BR112012025172A2 true BR112012025172A2 (pt) 2017-06-27
BR112012025172B1 BR112012025172B1 (pt) 2018-08-28

Family

ID=44515145

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012025172A BR112012025172B1 (pt) 2010-04-06 2011-03-31 células de ilhotas gabaritadas e agrupamentos de células de ilhotas pequenas para tratamento de diabetes.

Country Status (10)

Country Link
US (2) US8735154B2 (pt)
EP (1) EP2555807B9 (pt)
JP (1) JP5956422B2 (pt)
CN (1) CN102958543B (pt)
AU (1) AU2011238540B2 (pt)
BR (1) BR112012025172B1 (pt)
CA (1) CA2795243C (pt)
DK (1) DK2555807T5 (pt)
MX (1) MX2012011644A (pt)
WO (1) WO2011126921A2 (pt)

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EP2286822A1 (en) 2009-08-17 2011-02-23 Universiteit Twente Diabetes treatment
US8895048B2 (en) 2010-04-06 2014-11-25 The University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment
WO2013016544A2 (en) * 2011-07-27 2013-01-31 University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment
WO2013156855A1 (en) * 2012-04-20 2013-10-24 Biolamina Ab Maintenance of differentiated cells with laminins
US20150320836A1 (en) * 2012-07-06 2015-11-12 The Regents Of The University Of California Cryopreservation of cells inside a macro-encapsulation device
JP6145257B2 (ja) * 2012-10-18 2017-06-07 株式会社クラレ エストロゲン活性を評価する方法
DK2909311T3 (da) 2012-10-18 2020-10-12 Univ Kansas Forbedret pålidelighed hos tests under anvendelse af en platform med flere fordybninger og flercellede klynger med flere kilder
KR102181336B1 (ko) 2013-06-13 2020-11-24 오르제네시스 엘티디. 세포 집단, 이의 전환분화 방법 및 이용 방법
CA2923504A1 (en) * 2013-09-19 2015-03-26 Beta-Cell Nv Method for the treatment of diabetes mellitus
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
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US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
WO2016181220A2 (en) 2015-05-13 2016-11-17 Ions Pharmaceutical S.À R.L. Therapeutic compositions and methods of use thereof
US20160106687A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
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US10597639B2 (en) 2016-10-20 2020-03-24 Washington University 3D-printed scaffold device for cell transplantation
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof
EP3630135A4 (en) * 2017-05-29 2021-03-03 Orgenesis Ltd. COMPOSITIONS AND METHOD OF PROVIDING CELL REPLACEMENT THERAPY
US20210369788A1 (en) 2017-11-08 2021-12-02 Animal Cell Therapy - Act Production of canine pancreatic islets from an immature pancreas
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Also Published As

Publication number Publication date
BR112012025172B1 (pt) 2018-08-28
AU2011238540B2 (en) 2014-12-04
DK2555807T3 (da) 2019-11-11
EP2555807B9 (en) 2021-12-08
US20100233239A1 (en) 2010-09-16
WO2011126921A2 (en) 2011-10-13
JP2013524787A (ja) 2013-06-20
CA2795243A1 (en) 2011-10-13
CA2795243C (en) 2019-06-11
US20140219997A1 (en) 2014-08-07
US8735154B2 (en) 2014-05-27
WO2011126921A3 (en) 2012-01-19
MX2012011644A (es) 2013-02-11
DK2555807T5 (da) 2022-01-03
JP5956422B2 (ja) 2016-07-27
AU2011238540A1 (en) 2012-11-29
CN102958543B (zh) 2016-01-13
CN102958543A (zh) 2013-03-06
EP2555807A2 (en) 2013-02-13
EP2555807B1 (en) 2019-07-31

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2716 DE 24-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.