BR112012020780A2 - forma sólida, composição farmacêutica, e, uso de uma forma sólida. - Google Patents
forma sólida, composição farmacêutica, e, uso de uma forma sólida.Info
- Publication number
- BR112012020780A2 BR112012020780A2 BR112012020780A BR112012020780A BR112012020780A2 BR 112012020780 A2 BR112012020780 A2 BR 112012020780A2 BR 112012020780 A BR112012020780 A BR 112012020780A BR 112012020780 A BR112012020780 A BR 112012020780A BR 112012020780 A2 BR112012020780 A2 BR 112012020780A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid form
- pharmaceutical composition
- solid
- forms
- methylpiperazin
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 8
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- -1 (r) -4-cyclobutyl-2-methylpiperazin-1-yl Chemical group 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30558110P | 2010-02-18 | 2010-02-18 | |
| PCT/SE2011/050170 WO2011102793A1 (en) | 2010-02-18 | 2011-02-17 | Solid forms comprising a cyclopropyl amide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012020780A2 true BR112012020780A2 (pt) | 2016-05-03 |
Family
ID=44370079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012020780A BR112012020780A2 (pt) | 2010-02-18 | 2011-02-17 | forma sólida, composição farmacêutica, e, uso de uma forma sólida. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110201622A1 (https=) |
| EP (1) | EP2536701A4 (https=) |
| JP (1) | JP5746718B2 (https=) |
| KR (1) | KR20130034009A (https=) |
| CN (1) | CN103140481A (https=) |
| AR (1) | AR080203A1 (https=) |
| AU (1) | AU2011218490B9 (https=) |
| BR (1) | BR112012020780A2 (https=) |
| CA (1) | CA2789884A1 (https=) |
| CL (1) | CL2012002285A1 (https=) |
| IL (1) | IL221430A0 (https=) |
| MX (1) | MX2012009537A (https=) |
| NZ (1) | NZ602108A (https=) |
| RU (1) | RU2012136921A (https=) |
| SG (1) | SG183231A1 (https=) |
| TW (1) | TW201136898A (https=) |
| WO (1) | WO2011102793A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA08290520B1 (ar) | 2007-08-22 | 2012-02-22 | استرازينيكا ايه بي | مشتقات سيكلو بروبيل أميد وتركيبات صيدلية تحتوي عليها لعلاج حالة مرضية سببها مستقبلات هيستامين h3 |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| RU2012139082A (ru) * | 2010-02-18 | 2014-03-27 | Астразенека Аб | Способы получения производных циклопропиламида и связанных с ними промежуточных соединений |
| CN109438423A (zh) * | 2018-09-12 | 2019-03-08 | 通化师范学院 | 一种肺癌靶向化合物azd-3759的合成工艺的新方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637271A (https=) * | 1963-04-04 | 1900-01-01 | ||
| US3449427A (en) * | 1965-06-03 | 1969-06-10 | Smithkline Corp | Aminocyclopropane derivatives of 5h-dibenzo(a,d)cycloheptenes |
| US3697506A (en) * | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
| US3686335A (en) * | 1970-12-21 | 1972-08-22 | Smith Kline French Lab | 5-vinyl-5h-di benzo(a,d)cycloheptenes |
| US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| EP0435320B1 (en) * | 1989-12-29 | 1994-10-05 | Banyu Pharmaceutical Co., Ltd. | 2(2-Cyclopropylpyrrolidin-4-ylthio)-carbapenem derivatives |
| DE4131139A1 (de) * | 1991-09-19 | 1993-03-25 | Bayer Ag | Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure |
| US5721359A (en) * | 1993-03-12 | 1998-02-24 | Pharmacia & Upjohn Company | Crystalline ceftiofur free acid |
| US6383520B1 (en) * | 1998-06-26 | 2002-05-07 | Chugai Seiyaku Kabushiki Kaisha | Fine powder of L-α-aminoadipic acid derivative, oral solid preparations containing the same, and method for treatment of bulk powders |
| US6284761B1 (en) * | 1999-01-08 | 2001-09-04 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands |
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| US6521619B2 (en) * | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
| PL364625A1 (en) * | 2001-02-23 | 2004-12-13 | Merck & Co, Inc. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
| US7145002B2 (en) * | 2001-09-26 | 2006-12-05 | Merck & Co. Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
| US6861432B2 (en) * | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
| JP2005526800A (ja) * | 2002-03-22 | 2005-09-08 | エルジー・ライフ・サイエンシーズ・リミテッド | （２Ｓ）−Ｎ−５−［アミノ（イミノ）メチル］−２−チエニルメチル−１−（２Ｒ）−２−［（カルボキシルメチル）アミノ］−３，３−ジフェニルプロパノイル−２−ピロリジンカルボキサミド・ｎＨ２Ｏの新しい結晶形 |
| US20040077618A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
| US20040209858A1 (en) * | 2002-10-22 | 2004-10-21 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
| PL1615909T3 (pl) * | 2003-04-23 | 2009-01-30 | Glaxo Group Ltd | Pochodne piperazyny i ich zastosowanie w leczeniu chorób neurologicznych i psychicznych |
| AR045595A1 (es) * | 2003-09-04 | 2005-11-02 | Vertex Pharma | Composiciones utiles como inhibidores de proteinas quinasas |
| KR101336106B1 (ko) * | 2005-09-16 | 2013-12-05 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ3 수용체의 조절제로서 사이클로프로필 아민 |
| AU2007204426A1 (en) * | 2006-01-13 | 2007-07-19 | F. Hoffmann-La Roche Ag | Cyclohexyl piperazinyl methanone derivatives and their use as histamine H3 receptor modulators |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| CN103382174A (zh) * | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| TW200828371A (en) * | 2006-09-21 | 2008-07-01 | Matsushita Electric Industrial Co Ltd | Chip-type filter |
| SA08290520B1 (ar) * | 2007-08-22 | 2012-02-22 | استرازينيكا ايه بي | مشتقات سيكلو بروبيل أميد وتركيبات صيدلية تحتوي عليها لعلاج حالة مرضية سببها مستقبلات هيستامين h3 |
| MX2010003155A (es) * | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| PE20091313A1 (es) * | 2008-01-15 | 2009-09-03 | Lilly Co Eli | (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| RU2012139082A (ru) * | 2010-02-18 | 2014-03-27 | Астразенека Аб | Способы получения производных циклопропиламида и связанных с ними промежуточных соединений |
-
2011
- 2011-02-17 JP JP2012553848A patent/JP5746718B2/ja not_active Expired - Fee Related
- 2011-02-17 NZ NZ602108A patent/NZ602108A/en not_active IP Right Cessation
- 2011-02-17 WO PCT/SE2011/050170 patent/WO2011102793A1/en not_active Ceased
- 2011-02-17 MX MX2012009537A patent/MX2012009537A/es not_active Application Discontinuation
- 2011-02-17 RU RU2012136921/04A patent/RU2012136921A/ru not_active Application Discontinuation
- 2011-02-17 SG SG2012058848A patent/SG183231A1/en unknown
- 2011-02-17 EP EP20110744973 patent/EP2536701A4/en not_active Withdrawn
- 2011-02-17 BR BR112012020780A patent/BR112012020780A2/pt not_active IP Right Cessation
- 2011-02-17 AR ARP110100484A patent/AR080203A1/es unknown
- 2011-02-17 US US13/029,351 patent/US20110201622A1/en not_active Abandoned
- 2011-02-17 CN CN201180019676XA patent/CN103140481A/zh active Pending
- 2011-02-17 AU AU2011218490A patent/AU2011218490B9/en not_active Ceased
- 2011-02-17 CA CA2789884A patent/CA2789884A1/en not_active Abandoned
- 2011-02-17 TW TW100105298A patent/TW201136898A/zh unknown
- 2011-02-17 KR KR1020127024173A patent/KR20130034009A/ko not_active Withdrawn
-
2012
- 2012-08-13 IL IL221430A patent/IL221430A0/en unknown
- 2012-08-17 CL CL2012002285A patent/CL2012002285A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ602108A (en) | 2014-09-26 |
| JP5746718B2 (ja) | 2015-07-08 |
| US20110201622A1 (en) | 2011-08-18 |
| AU2011218490B9 (en) | 2014-12-18 |
| EP2536701A1 (en) | 2012-12-26 |
| IL221430A0 (en) | 2012-10-31 |
| KR20130034009A (ko) | 2013-04-04 |
| AU2011218490B2 (en) | 2014-11-13 |
| SG183231A1 (en) | 2012-09-27 |
| CA2789884A1 (en) | 2011-08-25 |
| JP2013520412A (ja) | 2013-06-06 |
| MX2012009537A (es) | 2012-08-31 |
| TW201136898A (en) | 2011-11-01 |
| WO2011102793A1 (en) | 2011-08-25 |
| EP2536701A4 (en) | 2014-05-07 |
| AU2011218490A1 (en) | 2012-10-04 |
| AR080203A1 (es) | 2012-03-21 |
| CL2012002285A1 (es) | 2013-01-25 |
| RU2012136921A (ru) | 2014-03-27 |
| CN103140481A (zh) | 2013-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |