BR112012017349A2 - "composição farmacêuticas de proteínas de igf-i, um tamponamento e um agente de tonicidade" - Google Patents
"composição farmacêuticas de proteínas de igf-i, um tamponamento e um agente de tonicidade"Info
- Publication number
- BR112012017349A2 BR112012017349A2 BR112012017349A BR112012017349A BR112012017349A2 BR 112012017349 A2 BR112012017349 A2 BR 112012017349A2 BR 112012017349 A BR112012017349 A BR 112012017349A BR 112012017349 A BR112012017349 A BR 112012017349A BR 112012017349 A2 BR112012017349 A2 BR 112012017349A2
- Authority
- BR
- Brazil
- Prior art keywords
- igf
- tonicity agent
- pharmaceutical compositions
- protein
- buffering
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000012929 tonicity agent Substances 0.000 title abstract 3
- 239000006172 buffering agent Substances 0.000 title 1
- 230000003139 buffering effect Effects 0.000 title 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 208000026072 Motor neurone disease Diseases 0.000 abstract 1
- 206010068871 Myotonic dystrophy Diseases 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 201000010901 lateral sclerosis Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006938 muscular dystrophy Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 208000002320 spinal muscular atrophy Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
patente de invenção: "composições farmacêuticas de proteínas de igf-i, um tamponamento e um agente de tonicidade". a presente invenção refere-se a uma composição farmacêutica, compreendendo uma proteína de fator de crescimento de tipo insulina i (igf-i) como ingrediente farmacêutico (api), um agente de tonicidade e um tampão. essa composição pode ser administrada como injeção ou infusão e é especialmente últil para o tratamento, prevenção e/ou atraso de progressão de desordens neurodegenerativas, em particular doença de alzheimer (ad), uma doença de neurônio motor (mnd), em particular esclerose lateral amiotrófica (als) ou atrofia muscualr espinhal (sma) ou uma distrofia muscular (md), em particular distrofia muscular de duchenne (dmd) ou distrofia miotônica (mmd).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09180607 | 2009-12-23 | ||
PCT/EP2010/070174 WO2011076702A1 (en) | 2009-12-23 | 2010-12-20 | Pharmaceutical compositions comprising igf-1 proteins, a buffering and a tonicity agent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012017349A2 true BR112012017349A2 (pt) | 2017-06-13 |
Family
ID=43598371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012017349A BR112012017349A2 (pt) | 2009-12-23 | 2010-12-20 | "composição farmacêuticas de proteínas de igf-i, um tamponamento e um agente de tonicidade" |
Country Status (10)
Country | Link |
---|---|
US (1) | US20110152188A1 (pt) |
EP (1) | EP2515868A1 (pt) |
JP (1) | JP2013514340A (pt) |
KR (1) | KR20120106854A (pt) |
CN (1) | CN102665682A (pt) |
BR (1) | BR112012017349A2 (pt) |
CA (1) | CA2780080A1 (pt) |
MX (1) | MX2012007102A (pt) |
RU (1) | RU2012130606A (pt) |
WO (1) | WO2011076702A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120294866A1 (en) * | 2010-01-19 | 2012-11-22 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation for proteins |
US20130274235A1 (en) * | 2010-10-08 | 2013-10-17 | The General Hospital Corporation | Treatment of motor neuron disease |
WO2015095650A1 (en) | 2013-12-19 | 2015-06-25 | Puretein Bioscience Llc. | Methods for treating an animal |
TWI820795B (zh) | 2015-07-30 | 2023-11-01 | 美商拜奧馬林製藥公司 | C型利尿鈉肽變異體治療骨骼發育不良之用途 |
RS63812B1 (sr) * | 2018-01-26 | 2023-01-31 | Hoffmann La Roche | Il-22 fc kompozicije i postupci primene |
WO2023139115A1 (en) * | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3486216T2 (de) | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US6235488B1 (en) * | 1988-09-29 | 2001-05-22 | Agilent Technologies, Inc. | Surface preparation for chemical-specific binding |
US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
WO1993002695A1 (en) * | 1991-08-01 | 1993-02-18 | Genentech, Inc. | Igf-1 to improve the neural condition |
US5861373A (en) * | 1991-08-01 | 1999-01-19 | Genentech, Inc | IGF-1 to improve the neural condition |
SE9300105D0 (sv) * | 1993-01-15 | 1993-01-15 | Kabi Pharmacia Ab | Stable protein solution |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
CN1246891A (zh) * | 1997-02-06 | 2000-03-08 | 诺沃挪第克公司 | 添加和/或除去了连接基团的多肽-聚合物偶联物 |
US7067485B2 (en) * | 1997-11-07 | 2006-06-27 | Chiron Corporation | IGF-I composition and its use |
AU1384799A (en) * | 1997-11-07 | 1999-05-31 | Chiron Corporation | Novel igf-i composition and its use |
US6767892B1 (en) * | 1997-11-07 | 2004-07-27 | Chrion Corporation | Compositions providing for increased IGF-I solubility |
AU3764199A (en) * | 1998-04-29 | 1999-11-16 | Genentech Inc. | Spray dried formulations of igf-i |
US6436897B2 (en) * | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
DK1141014T3 (da) * | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
AU762047B2 (en) * | 1999-01-06 | 2003-06-19 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
DK1165119T3 (da) * | 1999-04-08 | 2003-12-15 | Genentech Inc | Sammensætning baseret på modsat ladede polypeptider |
US6596849B1 (en) * | 1999-05-28 | 2003-07-22 | Academia Sinica | Monoclonal-antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules |
US7431921B2 (en) * | 2000-04-14 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
US20020082215A1 (en) | 2000-10-13 | 2002-06-27 | Chiron Corporation | Method for treating ischemic events affecting the central nervous system |
EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
AU2006330858A1 (en) * | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
ES2388827T3 (es) * | 2008-04-03 | 2012-10-19 | F. Hoffmann-La Roche Ag | Uso de variantes de IGF-I PEGiladas para el tratamiento de trastornos neuromusculares |
-
2010
- 2010-12-16 US US12/969,619 patent/US20110152188A1/en not_active Abandoned
- 2010-12-20 EP EP10798080A patent/EP2515868A1/en not_active Withdrawn
- 2010-12-20 JP JP2012543809A patent/JP2013514340A/ja active Pending
- 2010-12-20 MX MX2012007102A patent/MX2012007102A/es not_active Application Discontinuation
- 2010-12-20 CN CN201080058206XA patent/CN102665682A/zh active Pending
- 2010-12-20 WO PCT/EP2010/070174 patent/WO2011076702A1/en active Application Filing
- 2010-12-20 RU RU2012130606/15A patent/RU2012130606A/ru unknown
- 2010-12-20 CA CA2780080A patent/CA2780080A1/en not_active Abandoned
- 2010-12-20 BR BR112012017349A patent/BR112012017349A2/pt not_active Application Discontinuation
- 2010-12-20 KR KR1020127019211A patent/KR20120106854A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2515868A1 (en) | 2012-10-31 |
CN102665682A (zh) | 2012-09-12 |
KR20120106854A (ko) | 2012-09-26 |
WO2011076702A1 (en) | 2011-06-30 |
JP2013514340A (ja) | 2013-04-25 |
RU2012130606A (ru) | 2014-01-27 |
US20110152188A1 (en) | 2011-06-23 |
MX2012007102A (es) | 2012-07-23 |
CA2780080A1 (en) | 2011-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |