BR112012011347A2 - "moduladores de receptor alfa adrenérgico." - Google Patents

"moduladores de receptor alfa adrenérgico."

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Publication number
BR112012011347A2
BR112012011347A2 BR112012011347A BR112012011347A BR112012011347A2 BR 112012011347 A2 BR112012011347 A2 BR 112012011347A2 BR 112012011347 A BR112012011347 A BR 112012011347A BR 112012011347 A BR112012011347 A BR 112012011347A BR 112012011347 A2 BR112012011347 A2 BR 112012011347A2
Authority
BR
Brazil
Prior art keywords
alpha adrenergic
receptor modulators
adrenergic receptor
compounds
alpha
Prior art date
Application number
BR112012011347A
Other languages
English (en)
Inventor
W Gil Daniel
G Corpuz Evelyn
Chow Ken
Wang Liming
K Fang Wenkui
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112012011347A2 publication Critical patent/BR112012011347A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Dermatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
  • Otolaryngology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

moduladores de receptor alfa adrenérgico. compostos são descritos neste documento úteis para tratar doenças e condições pela modução de um ou mais receptores alfa adrenérgicos, em particular o receptor alfa 2c. os compostos podem incluir derivados n-(2,3-substituído fenil)-3,4-diidro-2h-pirrol-5-amina. métodos de fazer, usar e formular estes compostos são descritos.
BR112012011347A 2009-10-21 2010-10-20 "moduladores de receptor alfa adrenérgico." BR112012011347A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25365409P 2009-10-21 2009-10-21
PCT/US2010/053327 WO2011050030A1 (en) 2009-10-21 2010-10-20 Alpha adrenergic receptor modulators

Publications (1)

Publication Number Publication Date
BR112012011347A2 true BR112012011347A2 (pt) 2019-09-24

Family

ID=43531175

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012011347A BR112012011347A2 (pt) 2009-10-21 2010-10-20 "moduladores de receptor alfa adrenérgico."

Country Status (11)

Country Link
US (1) US20120238615A1 (pt)
EP (1) EP2491017B1 (pt)
JP (1) JP2013508384A (pt)
KR (1) KR20120098720A (pt)
CN (1) CN102666484A (pt)
AU (1) AU2010310800A1 (pt)
BR (1) BR112012011347A2 (pt)
CA (1) CA2778423A1 (pt)
IN (1) IN2012DN03844A (pt)
RU (1) RU2012119247A (pt)
WO (1) WO2011050030A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS55061B1 (sr) * 2011-04-19 2016-12-30 Univ Strasbourg Novi derivati amino-pirolina i njihova upotreba u prevenciji i/ili lečenju metaboličkog sindroma
FR2974364B1 (fr) * 2011-04-19 2013-10-11 Univ Strasbourg Nouveaux derives amino-pyrroliniques, leur utilisation dans la prevention et/ou le traitement du syndrome metabolique
CA2899339C (en) 2013-02-01 2021-07-06 Ocularis Pharma, Llc Aqueous ophthalmic solutions of phentolamine and medical uses thereof
AU2014212275B2 (en) 2013-02-01 2018-09-06 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
JP2022505950A (ja) 2018-10-26 2022-01-14 オキュフィア・ファーマ・インコーポレイテッド 老眼、散瞳、および他の眼障害の治療のための方法および組成物
IT201900021435A1 (it) 2019-11-18 2021-05-18 Airmec Srl Impianto idroelettrico a vite idrodinamica
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Also Published As

Publication number Publication date
JP2013508384A (ja) 2013-03-07
EP2491017B1 (en) 2014-08-27
RU2012119247A (ru) 2013-11-27
US20120238615A1 (en) 2012-09-20
WO2011050030A1 (en) 2011-04-28
KR20120098720A (ko) 2012-09-05
CA2778423A1 (en) 2011-04-28
EP2491017A1 (en) 2012-08-29
IN2012DN03844A (pt) 2015-08-28
AU2010310800A1 (en) 2012-05-17
CN102666484A (zh) 2012-09-12

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.