BR112012010253A8 - compostos de pirimidina como moduladores do receptor delta opioide - Google Patents

compostos de pirimidina como moduladores do receptor delta opioide

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Publication number
BR112012010253A8
BR112012010253A8 BR112012010253A BR112012010253A BR112012010253A8 BR 112012010253 A8 BR112012010253 A8 BR 112012010253A8 BR 112012010253 A BR112012010253 A BR 112012010253A BR 112012010253 A BR112012010253 A BR 112012010253A BR 112012010253 A8 BR112012010253 A8 BR 112012010253A8
Authority
BR
Brazil
Prior art keywords
receptor modulators
pyrimidine compounds
delta receptor
opioid delta
compounds
Prior art date
Application number
BR112012010253A
Other languages
English (en)
Other versions
BR112012010253A2 (pt
Inventor
Bart L Decorte
Bin Zhu
Chaozhong Cai
Gilles Bignan
Haiyan Bian
Li Liu
Mark J Macielag
Peter J Connolly
Philip M Pitis
Scott L Dax
Shu-Chen Lin
Steven J Coats
Wei He
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112012010253A2 publication Critical patent/BR112012010253A2/pt
Publication of BR112012010253A8 publication Critical patent/BR112012010253A8/pt

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

compostos de pirimidina como moduladores do receptor delta opioide. a presente invenção refere-se a compostos, composições e métodos para o tratamento de várias doenças, síndromes, condições e distúrbios, incluindo dor. tais compostos são representados pela fórmula i a seguir, sendo que r^ 1~, r^ 2^, r^ 3^ e l,a e r^ a^ são aqui definidos.
BR112012010253A 2009-10-30 2010-10-28 compostos de pirimidina como moduladores do receptor delta opioide BR112012010253A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25640509P 2009-10-30 2009-10-30
PCT/US2010/054489 WO2011053705A1 (en) 2009-10-30 2010-10-28 Pyrimidine compounds as delta opioid receptor modulators

Publications (2)

Publication Number Publication Date
BR112012010253A2 BR112012010253A2 (pt) 2016-03-29
BR112012010253A8 true BR112012010253A8 (pt) 2016-10-04

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ID=43447850

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BR112012010253A BR112012010253A8 (pt) 2009-10-30 2010-10-28 compostos de pirimidina como moduladores do receptor delta opioide

Country Status (9)

Country Link
US (3) US20110269759A1 (pt)
EP (1) EP2493877B1 (pt)
JP (1) JP5782042B2 (pt)
CN (1) CN102741240B (pt)
AU (1) AU2010313401B2 (pt)
BR (1) BR112012010253A8 (pt)
CA (1) CA2779107C (pt)
RU (1) RU2568434C2 (pt)
WO (1) WO2011053705A1 (pt)

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BR112019016775A2 (pt) 2017-02-17 2020-03-31 Trevena, Inc. Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos
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CA2779107A1 (en) 2011-05-05
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EP2493877B1 (en) 2014-09-17
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US8513271B2 (en) 2013-08-20
AU2010313401B2 (en) 2015-07-23
US20110105520A1 (en) 2011-05-05
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