BR102017016923A8 - Peptídeos ligantes à proteína catiônica eosinofílica e suas aplicações no diagnóstico da esofagite eosinofílica - Google Patents
Peptídeos ligantes à proteína catiônica eosinofílica e suas aplicações no diagnóstico da esofagite eosinofílicaInfo
- Publication number
- BR102017016923A8 BR102017016923A8 BR102017016923A BR102017016923A BR102017016923A8 BR 102017016923 A8 BR102017016923 A8 BR 102017016923A8 BR 102017016923 A BR102017016923 A BR 102017016923A BR 102017016923 A BR102017016923 A BR 102017016923A BR 102017016923 A8 BR102017016923 A8 BR 102017016923A8
- Authority
- BR
- Brazil
- Prior art keywords
- eosinophilic
- diagnosis
- cationic protein
- binding peptides
- applications
- Prior art date
Links
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 title abstract 5
- 201000000708 eosinophilic esophagitis Diseases 0.000 title abstract 5
- 125000002091 cationic group Chemical group 0.000 title abstract 4
- 238000003745 diagnosis Methods 0.000 title abstract 4
- 230000002327 eosinophilic effect Effects 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 208000026935 allergic disease Diseases 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 2
- 230000001900 immune effect Effects 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
PEPTÍDEOS LIGANTES À PROTEÍNA CATIÔNICA EOSINOFÍLICA E SUAS APLICAÇÕES NO DIAGNÓSTICO DA ESOFAGITE EOSINOFÍLICA. A presente invenção refere-se à seleção, caracterização e utilização de peptídeos ligantes da Proteína Catiônica Eosinofílica (PCE) no diagnóstico imunológico da Esofagite Eosinofílica e de doenças alérgicas/inflamatórias, controle da inflamação e tratamento de doenças alérgicas e inflamatórias. Nesse contexto, a invenção compreende 24 peptídeos desenvolvidos a partir do seu potencial de reconhecimento da proteína catiônica eosinofílica recombinante humana. Um desses ligantes selecionados foi escolhido a título de exemplificação para ser validado para o diagnóstico imunológico da Esofagite Eosinofílica (EEo) em amostras de muco esofágico de pacientes pediátricos portadores da doença.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102017016923A BR102017016923A8 (pt) | 2017-08-07 | 2017-08-07 | Peptídeos ligantes à proteína catiônica eosinofílica e suas aplicações no diagnóstico da esofagite eosinofílica |
| PCT/BR2018/050281 WO2019028539A1 (pt) | 2017-08-07 | 2018-08-07 | Peptídeos ligantes à proteína catiônica eosinofìlica e suas aplicações no diagnóstico da esofagite eosinofílica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102017016923A BR102017016923A8 (pt) | 2017-08-07 | 2017-08-07 | Peptídeos ligantes à proteína catiônica eosinofílica e suas aplicações no diagnóstico da esofagite eosinofílica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR102017016923A2 BR102017016923A2 (pt) | 2020-04-28 |
| BR102017016923A8 true BR102017016923A8 (pt) | 2022-08-23 |
Family
ID=65273197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR102017016923A BR102017016923A8 (pt) | 2017-08-07 | 2017-08-07 | Peptídeos ligantes à proteína catiônica eosinofílica e suas aplicações no diagnóstico da esofagite eosinofílica |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BR102017016923A8 (pt) |
| WO (1) | WO2019028539A1 (pt) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551791B1 (en) * | 1995-12-21 | 2003-04-22 | University Of Florida | Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit |
| US20030055231A1 (en) * | 1998-10-28 | 2003-03-20 | Jian Ni | 12 human secreted proteins |
| EP1130028A1 (en) * | 2000-02-18 | 2001-09-05 | Francesco Marcucci | Process for the preparation of a mucosal form of the eosinophil cationic protein (ECP), mucosal ECP and uses thereof as allergic phlogosis marker |
-
2017
- 2017-08-07 BR BR102017016923A patent/BR102017016923A8/pt not_active Application Discontinuation
-
2018
- 2018-08-07 WO PCT/BR2018/050281 patent/WO2019028539A1/pt active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019028539A1 (pt) | 2019-02-14 |
| BR102017016923A2 (pt) | 2020-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B03H | Publication of an application: rectification [chapter 3.8 patent gazette] |
Free format text: RELATIVA AO ITEM (74); |
|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |