BR0316298A - Método e aparelho de cristalização usando uma montagem de placa de colisão - Google Patents

Método e aparelho de cristalização usando uma montagem de placa de colisão

Info

Publication number
BR0316298A
BR0316298A BR0316298-2A BR0316298A BR0316298A BR 0316298 A BR0316298 A BR 0316298A BR 0316298 A BR0316298 A BR 0316298A BR 0316298 A BR0316298 A BR 0316298A
Authority
BR
Brazil
Prior art keywords
collision plate
jet streams
plate assembly
crystallization method
pharmaceutically active
Prior art date
Application number
BR0316298-2A
Other languages
English (en)
Inventor
Steven James Brenek
David Jon Am Ende
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0316298A publication Critical patent/BR0316298A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODO E APARELHO DE CRISTALIZAçãO USANDO UMA MONTAGEM DE PLACA DE COLISãO". A presente invenção refere-se a um processo de cristalização para a produção de um produto farmacêutico a partir de soluções de compostos farmaceuticamente ativos ou seus intermediários reativos que emprega correntes de jato fluido contendo ingredientes farmaceuticamente ativos, anti-solventes apropriados e/ou seus intermediários reativos capazes da produção de um produto farmacêutico com características de tamanho de partícula desejado na mistura, reação química, nucleação e precipitação. As correntes de jato são dirigidas na direção de uma placa de colisão e a mistura ocorre à medida que as correntes de jato colidem com a placa em uma área de impato desejada.
BR0316298-2A 2002-11-27 2003-11-21 Método e aparelho de cristalização usando uma montagem de placa de colisão BR0316298A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42964302P 2002-11-27 2002-11-27
PCT/IB2003/005354 WO2004047797A2 (en) 2002-11-27 2003-11-21 Crystallization method and apparatus using an impinging plate assembly

Publications (1)

Publication Number Publication Date
BR0316298A true BR0316298A (pt) 2005-10-11

Family

ID=32393570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316298-2A BR0316298A (pt) 2002-11-27 2003-11-21 Método e aparelho de cristalização usando uma montagem de placa de colisão

Country Status (8)

Country Link
US (1) US20040098839A1 (pt)
EP (1) EP1567241A2 (pt)
JP (1) JP2006516105A (pt)
AU (1) AU2003294149A1 (pt)
BR (1) BR0316298A (pt)
CA (1) CA2500535A1 (pt)
MX (1) MXPA05005657A (pt)
WO (1) WO2004047797A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051511A1 (ja) * 2003-11-28 2005-06-09 Mitsubishi Chemical Corporation 有機化合物微粒子の製造方法
US7314516B2 (en) * 2004-12-29 2008-01-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
AU2006249808B2 (en) * 2005-05-25 2011-07-14 The Board Of Trustees Of The University Of Arkansas System and method for dissolving gases in fluids and for delivery of dissolved gases
EP1954653A4 (en) * 2005-11-23 2010-11-03 Merck Sharp & Dohme METHOD FOR PRODUCING AN AMORPHANT SOLID FOR WATER-INSOLUBLE PHARMACEUTICALS
US20090306339A1 (en) * 2006-09-19 2009-12-10 Van Boxtel Huibert Albertus Preparation of Fine Particles
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
WO2011079969A1 (en) * 2009-12-30 2011-07-07 Medichem S.A. A 1-(1h-1,2,4-triazol-1-yl)butan-2-ol derivative for pharmaceutical use, and the use of a 1-(1h-1,2,4-triazol-1-yl)butan-2-ol derivative with substantially undefined crystal shape for preparing said 1-(1h-1,2,4-triazol-1-yl)butan-2-ol derivative
FR2960164B1 (fr) * 2010-05-21 2014-03-28 Centre Nat Rech Scient Procede de production d'un materiau nanometrique et reacteur pour sa mise en oeuvre
FR2960167B1 (fr) * 2010-05-21 2013-02-08 Centre Nat Rech Scient Procede d'obtention de couches minces
US10077939B2 (en) * 2013-01-28 2018-09-18 Hewlett-Packard Development Company, L.P. To direct air to media
US9732068B1 (en) * 2013-03-15 2017-08-15 GenSyn Technologies, Inc. System for crystalizing chemical compounds and methodologies for utilizing the same
KR102092068B1 (ko) * 2018-03-26 2020-03-23 중앙대학교 산학협력단 약물 결정의 제조를 위한 비용매를 이용한 결정화 장치 및 이를 이용한 약물 결정의 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US16498A (en) * 1857-01-27 Improvement in harrows
GB741756A (en) * 1953-02-24 1955-12-14 Secr Defence Brit Method for producing fine crystals of controlled particle size
SE462704B (sv) * 1987-12-09 1990-08-20 Hg Tech Ab Foerfarande vid atomisering av vaetskor och anordning foer genomfoerande av foerfarandet
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
IE67187B1 (en) * 1990-06-15 1996-03-06 Merck & Co Inc A crystallization method to improve crystal structure and size
CA2143116A1 (en) * 1992-10-06 1994-04-14 Richard Dauer Dual jet crystallizer apparatus
ES2251965T3 (es) * 1999-01-29 2006-05-16 Bristol-Myers Squibb Company Aparato y procedimiento de cristalizacion por ultrasonidos con chorros en colision.
YU34501A (sh) * 2000-05-26 2003-10-31 Pfizer Products Inc. Postupak reaktivne kristalizacije radi povećanja veličine čestica
DE60210794T2 (de) * 2001-10-17 2007-05-10 E.I. Dupont De Nemours And Co., Wilmington Rotor-stator apparat und verfahren zur bildung von partikeln

Also Published As

Publication number Publication date
JP2006516105A (ja) 2006-06-22
EP1567241A2 (en) 2005-08-31
WO2004047797A8 (en) 2005-10-27
CA2500535A1 (en) 2004-06-10
AU2003294149A8 (en) 2004-06-18
AU2003294149A1 (en) 2004-06-18
MXPA05005657A (es) 2005-07-27
WO2004047797A2 (en) 2004-06-10
US20040098839A1 (en) 2004-05-27
WO2004047797A3 (en) 2005-05-26

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A,5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010.