BR0316259A - Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto - Google Patents
Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e compostoInfo
- Publication number
- BR0316259A BR0316259A BR0316259-1A BR0316259A BR0316259A BR 0316259 A BR0316259 A BR 0316259A BR 0316259 A BR0316259 A BR 0316259A BR 0316259 A BR0316259 A BR 0316259A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treating
- methods
- preventing
- disorder
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000006433 tumor necrosis factor production Effects 0.000 title abstract 2
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 2
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 2
- DHKAFTYWTCIWJX-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-3-(3-oxo-1h-isoindol-2-yl)propanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CC(N)=O)N1C(=O)C2=CC=CC=C2C1 DHKAFTYWTCIWJX-UHFFFAOYSA-N 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- Psychiatry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US42737902P | 2002-11-18 | 2002-11-18 | |
| PCT/US2003/036740 WO2004045597A1 (en) | 2002-11-18 | 2003-11-17 | Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0316259A true BR0316259A (pt) | 2005-10-04 |
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Country Status (12)
| Country | Link |
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| US (1) | US20060247296A1 (https=) |
| EP (1) | EP1581205A1 (https=) |
| JP (1) | JP2006510617A (https=) |
| KR (1) | KR20050075435A (https=) |
| CN (1) | CN1738613A (https=) |
| AU (1) | AU2003294311B8 (https=) |
| BR (1) | BR0316259A (https=) |
| CA (1) | CA2506232A1 (https=) |
| MX (1) | MXPA05005164A (https=) |
| NZ (1) | NZ540547A (https=) |
| WO (1) | WO2004045597A1 (https=) |
| ZA (1) | ZA200503925B (https=) |
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| JP2006510606A (ja) * | 2002-10-15 | 2006-03-30 | セルジーン・コーポレーション | 骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物 |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
| CA2590903A1 (en) * | 2004-12-13 | 2006-06-22 | Celgene Corporation | Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| TW200716140A (en) * | 2005-06-17 | 2007-05-01 | Dynamis Therapeutics Inc | Treatment of inflammatory conditions |
| US20170105964A1 (en) * | 2014-06-18 | 2017-04-20 | The General Hospital Corporation | Methods and compositions for the modulation of beta-endorphin levels |
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-
2003
- 2003-11-17 JP JP2004553837A patent/JP2006510617A/ja not_active Withdrawn
- 2003-11-17 CN CNA2003801089239A patent/CN1738613A/zh active Pending
- 2003-11-17 KR KR1020057008935A patent/KR20050075435A/ko not_active Withdrawn
- 2003-11-17 MX MXPA05005164A patent/MXPA05005164A/es not_active Application Discontinuation
- 2003-11-17 AU AU2003294311A patent/AU2003294311B8/en not_active Expired - Fee Related
- 2003-11-17 BR BR0316259-1A patent/BR0316259A/pt not_active IP Right Cessation
- 2003-11-17 EP EP03789794A patent/EP1581205A1/en not_active Withdrawn
- 2003-11-17 NZ NZ540547A patent/NZ540547A/en unknown
- 2003-11-17 CA CA002506232A patent/CA2506232A1/en not_active Abandoned
- 2003-11-17 WO PCT/US2003/036740 patent/WO2004045597A1/en not_active Ceased
-
2005
- 2005-05-16 ZA ZA200503925A patent/ZA200503925B/xx unknown
- 2005-08-30 US US10/535,004 patent/US20060247296A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200503925B (en) | 2006-08-30 |
| EP1581205A1 (en) | 2005-10-05 |
| US20060247296A1 (en) | 2006-11-02 |
| JP2006510617A (ja) | 2006-03-30 |
| AU2003294311B2 (en) | 2008-05-08 |
| AU2003294311A1 (en) | 2004-06-15 |
| WO2004045597A1 (en) | 2004-06-03 |
| KR20050075435A (ko) | 2005-07-20 |
| CA2506232A1 (en) | 2004-06-03 |
| MXPA05005164A (es) | 2005-07-22 |
| AU2003294311B8 (en) | 2008-06-05 |
| NZ540547A (en) | 2008-03-28 |
| CN1738613A (zh) | 2006-02-22 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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