BR0314478A - Derivado de 6-metilpiridina, método para sua preparação e composição farmacêutica contendo o mesmo - Google Patents

Derivado de 6-metilpiridina, método para sua preparação e composição farmacêutica contendo o mesmo

Info

Publication number
BR0314478A
BR0314478A BR0314478-0A BR0314478A BR0314478A BR 0314478 A BR0314478 A BR 0314478A BR 0314478 A BR0314478 A BR 0314478A BR 0314478 A BR0314478 A BR 0314478A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
preparation
same
composition containing
hepatitis
Prior art date
Application number
BR0314478-0A
Other languages
English (en)
Inventor
Jong-Woo Kim
Sang-Wook Lee
Geun-Hyung Lee
Jae-Jin Han
Sang-Jin Park
Eul-Yong Park
Joong-Chul Shin
Original Assignee
B & C Biopharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B & C Biopharm filed Critical B & C Biopharm
Publication of BR0314478A publication Critical patent/BR0314478A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

"DERIVADO DE 6-METILPIRIDINA, MéTODO PARA SUA PREPARAçãO E COMPOSIçãO FARMACêUTICA CONTENDO O MESMO". A presente invenção refere-se a derivados de 6-metilpiridina úteis como agente antiviral e mais particularmente, a derivado de 6-metilpiridina novo com excelente efeito inibidor sobre a replicação de vírus de hepatite C (HCV) representado pela fórmula I seguinte: ou seus sais farmaceuticamente aceitáveis, a um método para sua preparação, e a uma composição farmacêutica antiviral compreendendo o composto como ingrediente ativo. O derivado de 6-metilpiridina da presente invenção possui um excelente efeito inibidor sobre a replicação de vírus de hepatite C (HCV) e pode assim ser vantajosamente utilizado como agente terapêutico ou profilático da hepatite C.
BR0314478-0A 2002-10-11 2003-10-02 Derivado de 6-metilpiridina, método para sua preparação e composição farmacêutica contendo o mesmo BR0314478A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0061994A KR100453946B1 (ko) 2002-10-11 2002-10-11 6-메틸피리딘 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물
PCT/KR2003/002034 WO2004033450A1 (en) 2002-10-11 2003-10-02 6-methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
BR0314478A true BR0314478A (pt) 2005-07-26

Family

ID=32089702

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314478-0A BR0314478A (pt) 2002-10-11 2003-10-02 Derivado de 6-metilpiridina, método para sua preparação e composição farmacêutica contendo o mesmo

Country Status (12)

Country Link
US (1) US7244731B2 (pt)
EP (1) EP1549642B1 (pt)
JP (1) JP2006506358A (pt)
KR (1) KR100453946B1 (pt)
CN (1) CN100355752C (pt)
AT (1) ATE370122T1 (pt)
AU (1) AU2003265122B2 (pt)
BR (1) BR0314478A (pt)
CA (1) CA2499642A1 (pt)
DE (1) DE60315685D1 (pt)
MX (1) MXPA05003159A (pt)
WO (1) WO2004033450A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004050283A1 (de) * 2004-10-15 2006-04-27 Lanxess Deutschland Gmbh 4-Aminophenyl-morpholinon-Derivate und deren Herstellung
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2187317B2 (pt) * 1972-06-07 1975-06-20 Hexachimie
US3878206A (en) * 1973-06-06 1975-04-15 Morton Norwich Products Inc 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines
EP0187705A3 (en) 1985-01-08 1988-05-11 Norwich Eaton Pharmaceuticals, Inc. Imidazo(4,5-f)quinolines useful as immunomodulating agents
KR100566194B1 (ko) * 1999-12-29 2006-03-29 동화약품공업주식회사 신규의 3-니트로피리딘 유도체 및 그를 포함하는 약학적조성물
KR100566193B1 (ko) * 1999-11-27 2006-03-29 동화약품공업주식회사 신규의 3-니트로피리딘 유도체 및 그를 포함하는 약학적조성물
WO2001078648A2 (en) * 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
AU2002256085A1 (en) * 2001-04-06 2002-10-21 Smithkline Beecham Corporation Quinoline inhibitors of hyak1 and hyak3 kinases

Also Published As

Publication number Publication date
CN1694880A (zh) 2005-11-09
WO2004033450A1 (en) 2004-04-22
KR20040033099A (ko) 2004-04-21
EP1549642A4 (en) 2006-09-20
DE60315685D1 (de) 2007-09-27
US7244731B2 (en) 2007-07-17
CA2499642A1 (en) 2004-04-22
ATE370122T1 (de) 2007-09-15
CN100355752C (zh) 2007-12-19
EP1549642A1 (en) 2005-07-06
AU2003265122B2 (en) 2006-11-02
MXPA05003159A (es) 2005-06-08
KR100453946B1 (ko) 2004-10-20
EP1549642B1 (en) 2007-08-15
US20060269609A1 (en) 2006-11-30
AU2003265122A1 (en) 2004-05-04
JP2006506358A (ja) 2006-02-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A , 5A , 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010.