BR0308355A - Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade disto - Google Patents
Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade distoInfo
- Publication number
- BR0308355A BR0308355A BR0308355-1A BR0308355A BR0308355A BR 0308355 A BR0308355 A BR 0308355A BR 0308355 A BR0308355 A BR 0308355A BR 0308355 A BR0308355 A BR 0308355A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- need
- pharmaceutical composition
- methods
- androgen receptor
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 210000000988 bone and bone Anatomy 0.000 title abstract 6
- 102000001307 androgen receptors Human genes 0.000 title abstract 4
- 108010080146 androgen receptors Proteins 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 208000001132 Osteoporosis Diseases 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title abstract 2
- 230000002917 arthritic effect Effects 0.000 title abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000011707 mineral Substances 0.000 title abstract 2
- 230000004048 modification Effects 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 8
- 230000004913 activation Effects 0.000 title 1
- 239000003098 androgen Substances 0.000 abstract 3
- 206010006895 Cachexia Diseases 0.000 abstract 2
- 206010002261 Androgen deficiency Diseases 0.000 abstract 1
- 208000032467 Aplastic anaemia Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010027304 Menopausal symptoms Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010049088 Osteopenia Diseases 0.000 abstract 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000026500 emaciation Diseases 0.000 abstract 1
- 201000003585 eunuchism Diseases 0.000 abstract 1
- 201000003617 glucocorticoid-induced osteoporosis Diseases 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000037106 male hypogonadism Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 201000006938 muscular dystrophy Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 206010036601 premature menopause Diseases 0.000 abstract 1
- 208000017942 premature ovarian failure 1 Diseases 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 238000002278 reconstructive surgery Methods 0.000 abstract 1
- 208000001076 sarcopenia Diseases 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36382202P | 2002-03-13 | 2002-03-13 | |
| PCT/US2003/008277 WO2003077919A1 (en) | 2002-03-13 | 2003-03-07 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308355A true BR0308355A (pt) | 2005-01-25 |
Family
ID=28041817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308355-1A BR0308355A (pt) | 2002-03-13 | 2003-03-07 | Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade disto |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7186838B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1485095A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4516316B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100938136B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1652786A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003218235B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0308355A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2478186C (cg-RX-API-DMAC7.html) |
| EC (1) | ECSP045287A (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20040822A2 (cg-RX-API-DMAC7.html) |
| IL (2) | IL163825A0 (cg-RX-API-DMAC7.html) |
| IS (1) | IS7425A (cg-RX-API-DMAC7.html) |
| MA (1) | MA27112A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04008800A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20044312L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ534946A (cg-RX-API-DMAC7.html) |
| PL (1) | PL372920A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2320670C2 (cg-RX-API-DMAC7.html) |
| UA (1) | UA78029C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003077919A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200406843B (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| CA2478186C (en) * | 2002-03-13 | 2011-08-23 | Merck & Co., Inc. | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
| KR20150053811A (ko) * | 2002-05-10 | 2015-05-18 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US20070088042A1 (en) * | 2004-09-09 | 2007-04-19 | Meissner Robert S | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
| US7446110B2 (en) * | 2003-09-10 | 2008-11-04 | Merck & Co., Inc. | 17-Heterocyclic-4-azasteroid derivatives as androgen receptor modulators |
| MXPA06002462A (es) * | 2003-10-14 | 2006-06-20 | Gtx Inc | Tratamiento de desordenes relacionados con huesos con moduladores del receptor de angrogeno selectivo. |
| CA2543956A1 (en) * | 2003-10-31 | 2005-05-19 | Merck & Co., Inc. | 21-heterocyclic-4-azasteroid derivatives as androgen receptor modulators |
| CA2551737C (en) | 2004-01-07 | 2009-11-10 | Endorecherche, Inc. | Helix 12 directed steroidal pharmaceutical products |
| US20080125403A1 (en) * | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US7410977B2 (en) | 2004-04-28 | 2008-08-12 | Merck & Co., Inc. | Fluorinated 4-azasteroids as androgen receptor modulators |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| AU2005280334A1 (en) * | 2004-08-25 | 2006-03-09 | Merck Sharp & Dohme Corp. | Androgen receptor modulators |
| EP2371367A1 (en) * | 2005-03-25 | 2011-10-05 | Merck Sharp & Dohme (I.A.) Corp. | Method of treating men with testosterone supplement and 5alpha reductase inhibitor |
| US7301026B2 (en) * | 2005-05-05 | 2007-11-27 | Merck & Co., Inc | Process for making fluorinated 4-azasteroid derivatives |
| TW200730505A (en) * | 2005-12-07 | 2007-08-16 | Merck & Co Inc | Polymorphs of an androgen receptor modulator |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US8183286B2 (en) | 2006-11-16 | 2012-05-22 | Gemmus Pharma Inc. | EP2 and EP4 agonists as agents for the treatment of influenza a viral infection |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| CA2709677C (en) | 2007-12-21 | 2017-03-14 | Lin Zhi | Selective androgen receptor modulators (sarms) and uses thereof |
| EP2247597A1 (en) * | 2008-02-07 | 2010-11-10 | Bristol-Myers Squibb Company | Fused heteroaryl modulators of glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| JP2013528223A (ja) | 2010-06-10 | 2013-07-08 | アラゴン ファーマシューティカルズ，インク． | エストロゲン受容体モジュレーターおよびその用途 |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| US9193714B2 (en) | 2011-12-14 | 2015-11-24 | Seragon Pharmaceuticals, Inc. | Fluorinated estrogen receptor modulators and uses thereof |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| HUE052574T2 (hu) | 2012-07-13 | 2021-05-28 | Oncternal Therapeutics Inc | Eljárás mellrákok kezelésére szelektív ösztrogén receptor modulátorral (SARM) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US9566310B2 (en) | 2012-09-10 | 2017-02-14 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| WO2014144606A2 (en) | 2013-03-15 | 2014-09-18 | Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| EP3613418A1 (en) | 2014-01-17 | 2020-02-26 | Ligand Pharmaceuticals, Inc. | Methods and compositions for modulating hormone levels |
| KR101586345B1 (ko) * | 2014-08-06 | 2016-01-18 | 한국생명공학연구원 | 에스트라디올 벤조에이트(Estradiol benzoate) 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US12139508B2 (en) | 2018-02-11 | 2024-11-12 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
| MX2021012690A (es) | 2019-04-19 | 2022-01-31 | Ligand Pharm Inc | Formas cristalinas y metodos para producir formas cristalinas de un compuesto. |
| CN112638928B (zh) | 2019-08-07 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 一种甾族类衍生物调节剂的盐及其晶型 |
| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| CN112851745B (zh) * | 2021-01-25 | 2021-11-16 | 广西民族大学 | 氮杂甾体吡啶类化合物及其合成与应用 |
| US20240293322A1 (en) | 2021-06-23 | 2024-09-05 | University Of Iowa Research Foundation | Sustained release formulations comprising a selective androgen receptor modulator |
| CN120289552A (zh) * | 2021-07-02 | 2025-07-11 | 石家庄迪斯凯威医药科技有限公司 | 一种甾体磷酸酯化合物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187278A (en) * | 1990-08-27 | 1993-02-16 | Merck & Co., Inc. | Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids |
| IE76452B1 (en) * | 1990-10-29 | 1997-10-22 | Sankyo Co | Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use |
| GB9216284D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives |
| TW408127B (en) * | 1993-09-17 | 2000-10-11 | Glaxo Inc | Androstenones |
| WO1997010217A1 (en) * | 1995-09-15 | 1997-03-20 | Merck & Co., Inc. | 4-azasteroids for treatment of hyperandrogenic conditions |
| WO1998025623A1 (en) * | 1996-12-09 | 1998-06-18 | Merck & Co., Inc. | Methods and compositions for preventing and treating bone loss |
| CA2478186C (en) * | 2002-03-13 | 2011-08-23 | Merck & Co., Inc. | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
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| IS7425A (is) | 2004-08-26 |
| CN1652786A (zh) | 2005-08-10 |
| NO20044312L (no) | 2004-10-12 |
| HRP20040822A2 (en) | 2005-06-30 |
| JP4516316B2 (ja) | 2010-08-04 |
| WO2003077919A1 (en) | 2003-09-25 |
| PL372920A1 (en) | 2005-08-08 |
| JP2010168391A (ja) | 2010-08-05 |
| NZ534946A (en) | 2007-05-31 |
| MXPA04008800A (es) | 2004-11-26 |
| EP1485095A4 (en) | 2009-11-18 |
| MA27112A1 (fr) | 2004-12-20 |
| EP1485095A1 (en) | 2004-12-15 |
| JP2005526082A (ja) | 2005-09-02 |
| KR20040097167A (ko) | 2004-11-17 |
| AU2003218235B2 (en) | 2008-05-15 |
| UA78029C2 (en) | 2007-02-15 |
| CA2478186A1 (en) | 2003-09-25 |
| US20050165039A1 (en) | 2005-07-28 |
| ZA200406843B (en) | 2007-06-27 |
| CA2478186C (en) | 2011-08-23 |
| US7186838B2 (en) | 2007-03-06 |
| RU2004130452A (ru) | 2005-04-10 |
| IL163825A0 (en) | 2005-12-18 |
| JP5268975B2 (ja) | 2013-08-21 |
| KR100938136B1 (ko) | 2010-01-22 |
| RU2320670C2 (ru) | 2008-03-27 |
| IL163825A (en) | 2010-12-30 |
| ECSP045287A (es) | 2004-10-26 |
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