BR0214048A - 1,4-benzodiazepinas substituìdas e seus usos para o tratamento de câncer - Google Patents
1,4-benzodiazepinas substituìdas e seus usos para o tratamento de câncerInfo
- Publication number
- BR0214048A BR0214048A BR0214048-9A BR0214048A BR0214048A BR 0214048 A BR0214048 A BR 0214048A BR 0214048 A BR0214048 A BR 0214048A BR 0214048 A BR0214048 A BR 0214048A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- cycloalkyl
- heteroaryl
- aralkyl
- aryl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
"1,4-BENZODIAZEPINAS SUBSTITUìDAS E SEUS USOS PARA O TRATAMENTO DE CâNCER". A presente invenção e voltada a 1,4-benzodiazipinas inéditas, a composições farmacêuticas suas e ao seu uso como inibidores de interações de HDM2-p53. Os compostos têm a fórmula (I) ou um solvato, hidrato ou sal seu farmaceuticamente aceitável, em que X e Y são independentemente -C(O)-, -CH~ 2~- ou -C(S)-; R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 7^, R^ 8', R^ b^, R^ c^, R^ d^ e M são definidos no presente. R^ 5^ é hidrogênio, alquila, cicloalquila, arila opcionalmente substituído, heteroarila opcionalmente substituído, aralquila opcionalmente substituído, heteroarila opcionalmente substituído, carbóxialquila, alcóxi-carbonila, alcóxi-alquila, amino-carbonila, amino-carbonil-alquila, alquilamino-carbonila ou alquilamino-carbonil-alquila; R^ 6^ é cicloalquila, arila, heteroarila, cicloalquil-alquila, aralquila, heteroaril-alquila ou um heterociclo saturado ou parcialmente insaturado, sendo cada um deles opcionalmente substituído; R^ 9^ é cicloalquila, arila, heteroarila, um heterociclo saturado ou parcialmente insaturado, cicloalquil-(alquila), aralquila ou heteroarilalquila, sendo cada um deles opcionalmente substituído; e R^ 10^ é - (CH~ 2~)~ n~-CO~ 2~R^ b^, - (CH~ 2~)~ m~CO~ 2~M,-(CH~ 2~)~ i~-OH ou - (CH~ 2~)~ j~ -CONR^ c^R^ d^; n é 0-8, m é 0-8, i é 1-8, j é 0-8.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33123501P | 2001-11-13 | 2001-11-13 | |
PCT/US2002/036208 WO2003041715A1 (en) | 2001-11-13 | 2002-11-13 | Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0214048A true BR0214048A (pt) | 2004-10-13 |
Family
ID=23293137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0214048-9A BR0214048A (pt) | 2001-11-13 | 2002-11-13 | 1,4-benzodiazepinas substituìdas e seus usos para o tratamento de câncer |
Country Status (26)
Country | Link |
---|---|
US (2) | US7067512B2 (pt) |
EP (1) | EP1443937B1 (pt) |
JP (1) | JP4497921B2 (pt) |
KR (1) | KR20050044413A (pt) |
CN (1) | CN1596114A (pt) |
AT (1) | ATE398453T1 (pt) |
AU (1) | AU2002340464B2 (pt) |
BR (1) | BR0214048A (pt) |
CA (1) | CA2466055A1 (pt) |
CY (1) | CY1108352T1 (pt) |
DE (1) | DE60227185D1 (pt) |
DK (1) | DK1443937T3 (pt) |
ES (1) | ES2309209T3 (pt) |
HR (1) | HRP20040415A2 (pt) |
HU (1) | HUP0402003A3 (pt) |
IL (1) | IL161692A0 (pt) |
MX (1) | MXPA04004500A (pt) |
NO (1) | NO20042146L (pt) |
NZ (1) | NZ532463A (pt) |
PL (1) | PL370176A1 (pt) |
PT (1) | PT1443937E (pt) |
RU (1) | RU2004118243A (pt) |
SI (1) | SI1443937T1 (pt) |
UA (1) | UA76798C2 (pt) |
WO (1) | WO2003041715A1 (pt) |
ZA (1) | ZA200403082B (pt) |
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US20040197893A1 (en) * | 2002-10-16 | 2004-10-07 | Carsten Schubert | HDM2-inhibitor complexes and uses thereof |
US20050227932A1 (en) * | 2002-11-13 | 2005-10-13 | Tianbao Lu | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction |
US7358241B2 (en) * | 2003-01-21 | 2008-04-15 | Thallion Pharmaceuticals, Inc. | Compositions and methods comprising farnesyl dibenzodiazepinones for treating neoplastic cells and conditions |
US7186713B2 (en) | 2003-01-21 | 2007-03-06 | Ecopia Biosciences, Inc. | Farnesyl dibenzodiazepinones and methods of treating cancer using same |
US7655646B2 (en) * | 2003-01-21 | 2010-02-02 | Thallion Pharmaceuticals, Inc. | Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals |
DE112004001191B4 (de) * | 2003-07-02 | 2017-11-09 | Corus Pharma Inc. | Verfahren zur Herstellung des L-Lysin-Salzes von Aztreonam und Verfahren zur Bestimmung des Verunreinigungsgrads in einem amorphen Aztreonam Lysin-Salz |
CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
SG155941A1 (en) | 2004-09-22 | 2009-10-29 | Janssen Pharmaceutica Nv | Inhibitors of the interaction between mdm2 and p53 |
WO2006035051A1 (en) | 2004-09-28 | 2006-04-06 | Janssen Pharmaceutica N.V. | A bacterial atp synthase binding domain |
US7763604B2 (en) * | 2005-05-16 | 2010-07-27 | Thallion Pharma Ceuticals, Inc. | Methods for administration of a farnesyl dibenzodiazepinone |
EP1948191B1 (en) * | 2005-11-01 | 2013-01-16 | The Regents of the University of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
US8232298B2 (en) | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
AU2007228784B2 (en) | 2006-03-22 | 2012-03-08 | Janssen Pharmaceutica N.V. | Cyclic-alkylaminederivatives as inhibitors of the interaction between MDM2 and p53 |
US8470785B2 (en) | 2006-07-28 | 2013-06-25 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
US8614192B2 (en) | 2006-07-28 | 2013-12-24 | Leiden University Medical Center | Method for treating ocular cancer |
WO2008072655A1 (ja) | 2006-12-14 | 2008-06-19 | Daiichi Sankyo Company, Limited | イミダゾチアゾール誘導体 |
TWI539947B (zh) | 2007-04-09 | 2016-07-01 | 米希爾金尼公司 | 組蛋白去乙醯基酶之抑制劑 |
NZ580801A (en) * | 2007-05-10 | 2012-09-28 | Bristol Myers Squibb Co | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
WO2008144981A1 (fr) * | 2007-05-25 | 2008-12-04 | Topharman Shanghai Co., Ltd. | Procédés et intermédiaires pour préparer une 4-acétyl-2,3,4,5-tétrahydro-1h-1,4-benzodiazépine |
JP5539864B2 (ja) * | 2007-06-12 | 2014-07-02 | アカオゲン,インコーポレーテッド | 抗菌剤 |
US8853406B2 (en) | 2007-08-06 | 2014-10-07 | Janssen Pharmaceutica Nv | Substituted phenylenediamines as inhibitors of the interaction between MDM2 and P53 |
AR070449A1 (es) * | 2008-02-22 | 2010-04-07 | Otsuka Pharma Co Ltd | Compuesto de benzodiazepina y composicion farmaceutica |
JPWO2009151069A1 (ja) | 2008-06-12 | 2011-11-17 | 第一三共株式会社 | 4,7−ジアザスピロ[2.5]オクタン環構造を有するイミダゾチアゾール誘導体 |
MX2011008195A (es) | 2009-02-04 | 2011-09-06 | Janssen Pharmaceutica Nv | Derivados de indol como agentes anticancer. |
FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
CN102321034B (zh) * | 2011-06-07 | 2014-08-13 | 中国人民解放军第二军医大学 | 硫代苯二氮卓类化合物及其作为药物的用途 |
WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
CN105693634B (zh) * | 2016-03-17 | 2018-12-11 | 清华大学 | 化合物及其用途 |
US10669242B2 (en) * | 2016-06-10 | 2020-06-02 | Venenum Biodesign, LLC | Clostridium difficile toxin inhibitors |
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CN110317294B (zh) * | 2018-03-30 | 2021-06-18 | 长春理工大学 | 一种三苯胺类温敏荧光聚合物及其制备方法 |
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CN117263873A (zh) * | 2022-06-15 | 2023-12-22 | 复旦大学 | 1,4-苯二氮䓬类化合物及其在制备抗肿瘤药物中的用途 |
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US6492553B1 (en) * | 1998-01-29 | 2002-12-10 | Aventis Pharamaceuticals Inc. | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
WO2000056721A1 (en) | 1999-03-23 | 2000-09-28 | Axys Pharmaceuticals, Inc. | Solid phase synthesis of benzodiazepine diones |
US6440959B1 (en) * | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
JP5127096B2 (ja) | 1999-04-30 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用 |
AU5826100A (en) | 1999-07-13 | 2001-01-30 | F. Hoffmann-La Roche Ag | Benzazepinones and quinazolines |
US6600016B1 (en) * | 1999-08-24 | 2003-07-29 | Advanced Syntech Llc | Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same |
WO2001055121A1 (fr) * | 2000-01-28 | 2001-08-02 | Kaken Pharmaceutical Co., Ltd. | Dérivés d'azépine |
-
2002
- 2002-11-13 IL IL16169202A patent/IL161692A0/xx unknown
- 2002-11-13 DE DE60227185T patent/DE60227185D1/de not_active Expired - Lifetime
- 2002-11-13 MX MXPA04004500A patent/MXPA04004500A/es active IP Right Grant
- 2002-11-13 BR BR0214048-9A patent/BR0214048A/pt not_active IP Right Cessation
- 2002-11-13 PL PL02370176A patent/PL370176A1/xx not_active Application Discontinuation
- 2002-11-13 CN CNA028239156A patent/CN1596114A/zh active Pending
- 2002-11-13 AU AU2002340464A patent/AU2002340464B2/en not_active Ceased
- 2002-11-13 DK DK02778828T patent/DK1443937T3/da active
- 2002-11-13 WO PCT/US2002/036208 patent/WO2003041715A1/en not_active Application Discontinuation
- 2002-11-13 JP JP2003543602A patent/JP4497921B2/ja not_active Expired - Fee Related
- 2002-11-13 PT PT02778828T patent/PT1443937E/pt unknown
- 2002-11-13 AT AT02778828T patent/ATE398453T1/de active
- 2002-11-13 US US10/292,876 patent/US7067512B2/en not_active Expired - Fee Related
- 2002-11-13 KR KR1020047007168A patent/KR20050044413A/ko not_active Application Discontinuation
- 2002-11-13 UA UA20040604569A patent/UA76798C2/uk unknown
- 2002-11-13 ES ES02778828T patent/ES2309209T3/es not_active Expired - Lifetime
- 2002-11-13 HU HU0402003A patent/HUP0402003A3/hu unknown
- 2002-11-13 RU RU2004118243/04A patent/RU2004118243A/ru not_active Application Discontinuation
- 2002-11-13 SI SI200230733T patent/SI1443937T1/sl unknown
- 2002-11-13 EP EP02778828A patent/EP1443937B1/en not_active Expired - Lifetime
- 2002-11-13 NZ NZ532463A patent/NZ532463A/en not_active IP Right Cessation
- 2002-11-13 CA CA002466055A patent/CA2466055A1/en not_active Abandoned
-
2004
- 2004-04-22 ZA ZA200403082A patent/ZA200403082B/en unknown
- 2004-05-07 HR HR20040415A patent/HRP20040415A2/hr not_active Application Discontinuation
- 2004-05-25 NO NO20042146A patent/NO20042146L/no not_active Application Discontinuation
-
2006
- 2006-03-09 US US11/371,964 patent/US20060148792A1/en not_active Abandoned
-
2008
- 2008-09-17 CY CY20081101010T patent/CY1108352T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2004118243A (ru) | 2006-01-10 |
MXPA04004500A (es) | 2004-08-11 |
CA2466055A1 (en) | 2003-05-22 |
PL370176A1 (en) | 2005-05-16 |
US7067512B2 (en) | 2006-06-27 |
SI1443937T1 (sl) | 2009-02-28 |
HUP0402003A3 (en) | 2005-06-28 |
HUP0402003A2 (hu) | 2005-02-28 |
US20030109518A1 (en) | 2003-06-12 |
PT1443937E (pt) | 2008-09-23 |
NO20042146L (no) | 2004-08-11 |
DK1443937T3 (da) | 2008-10-20 |
KR20050044413A (ko) | 2005-05-12 |
UA76798C2 (uk) | 2006-09-15 |
US20060148792A1 (en) | 2006-07-06 |
EP1443937B1 (en) | 2008-06-18 |
HRP20040415A2 (en) | 2005-04-30 |
DE60227185D1 (de) | 2008-07-31 |
CN1596114A (zh) | 2005-03-16 |
CY1108352T1 (el) | 2014-02-12 |
WO2003041715A1 (en) | 2003-05-22 |
IL161692A0 (en) | 2004-09-27 |
JP2005509005A (ja) | 2005-04-07 |
ZA200403082B (en) | 2005-04-22 |
ES2309209T3 (es) | 2008-12-16 |
AU2002340464B2 (en) | 2008-03-13 |
ATE398453T1 (de) | 2008-07-15 |
NZ532463A (en) | 2007-02-23 |
JP4497921B2 (ja) | 2010-07-07 |
EP1443937A1 (en) | 2004-08-11 |
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