BR0213988A - Moduladores de poliamida de transcrição de cox2 - Google Patents
Moduladores de poliamida de transcrição de cox2Info
- Publication number
- BR0213988A BR0213988A BR0213988-0A BR0213988A BR0213988A BR 0213988 A BR0213988 A BR 0213988A BR 0213988 A BR0213988 A BR 0213988A BR 0213988 A BR0213988 A BR 0213988A
- Authority
- BR
- Brazil
- Prior art keywords
- polyamide
- cox2 gene
- cox2
- modulators
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTO DE POLIAMIDA E PROCESSO PARA REGULAR A EXPRESSãO DE GENE COX2". A invenção refere-se a processos e composições, que são fornecidos para a regulagem da expressão do gene COX2 em uma célula. O processo inclui selecionar uma composição de poliamida compreendendo N-metil pirrol (Py) e N-metil imidazol (lm) para fornecer uma ligação específica ao DNA em um alvo de gene COX2 em uma célula. A poliamida é então combinada com a célula contendo o gene COX2, em que a poliamida liga-se ao sítio alvo promotor de gene COX2 e regula a transcrição do gene COX2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34485901P | 2001-11-07 | 2001-11-07 | |
| US41940502P | 2002-10-18 | 2002-10-18 | |
| PCT/US2002/035718 WO2003040337A2 (en) | 2001-11-07 | 2002-11-07 | Polyamide modulators of cox2 transcription |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0213988A true BR0213988A (pt) | 2004-08-31 |
Family
ID=26994132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0213988-0A BR0213988A (pt) | 2001-11-07 | 2002-11-07 | Moduladores de poliamida de transcrição de cox2 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030119891A1 (pt) |
| EP (1) | EP1442022A4 (pt) |
| JP (1) | JP2005508181A (pt) |
| AU (1) | AU2002356916A1 (pt) |
| BR (1) | BR0213988A (pt) |
| CA (1) | CA2466391A1 (pt) |
| MX (1) | MXPA04004366A (pt) |
| WO (1) | WO2003040337A2 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8993609B2 (en) | 2006-05-04 | 2015-03-31 | Nanovir, Llc | Compounds for treating papilloma virus infection |
| ATE555108T1 (de) * | 2006-05-04 | 2012-05-15 | Nanovir Llc | Polyamide zur behandlung des menschlichen papilloma-virus |
| BR112014008464A2 (pt) | 2011-10-10 | 2017-04-11 | Nanovir Llc | composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo |
| US9982020B2 (en) | 2011-10-10 | 2018-05-29 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403302B1 (en) * | 1992-09-17 | 2002-06-11 | California Institute Of Technology | Methods and compositions for triple helix formation |
| US6143901A (en) * | 1996-07-31 | 2000-11-07 | Genesoft, Inc. | Complex formation between dsDNA and pyrrole imidazole polyamides |
| US6090947A (en) * | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
| EP0968186A1 (en) * | 1996-02-26 | 2000-01-05 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded dna |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| DE19707205A1 (de) * | 1997-02-24 | 1998-09-03 | Piller Gmbh | Aufwickeleinrichtung |
| CA2286232A1 (en) * | 1997-04-06 | 1998-11-05 | California Institute Of Technology | Dna-binding pyrrole and imidazole polyamide derivatives |
| WO2000029022A1 (en) * | 1998-11-12 | 2000-05-25 | Algos Pharmaceutical Corporation | Cox-2 inhibitors in combination with centrally acting analgesics |
| ES2160062B1 (es) * | 1999-07-12 | 2002-05-16 | Esteve Labor Dr | Linea celular que comprende el promotor de la ciclooxigenasa-2 (cox-2) y un gen testigo y su empleo en la busqueda de inhibidores selectivos de la induccion transcripcional de cox-2. |
| CA2422520A1 (en) * | 2000-07-11 | 2002-01-17 | Universite De Geneve | Linked, sequence-specific dna-binding molecules |
-
2002
- 2002-11-07 BR BR0213988-0A patent/BR0213988A/pt not_active IP Right Cessation
- 2002-11-07 EP EP02802875A patent/EP1442022A4/en not_active Withdrawn
- 2002-11-07 MX MXPA04004366A patent/MXPA04004366A/es not_active Application Discontinuation
- 2002-11-07 CA CA002466391A patent/CA2466391A1/en not_active Abandoned
- 2002-11-07 US US10/289,794 patent/US20030119891A1/en not_active Abandoned
- 2002-11-07 WO PCT/US2002/035718 patent/WO2003040337A2/en not_active Application Discontinuation
- 2002-11-07 AU AU2002356916A patent/AU2002356916A1/en not_active Abandoned
- 2002-11-07 JP JP2003542584A patent/JP2005508181A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2466391A1 (en) | 2003-05-15 |
| AU2002356916A1 (en) | 2003-05-19 |
| US20030119891A1 (en) | 2003-06-26 |
| WO2003040337A2 (en) | 2003-05-15 |
| WO2003040337A3 (en) | 2004-03-11 |
| MXPA04004366A (es) | 2004-09-10 |
| EP1442022A4 (en) | 2005-05-04 |
| EP1442022A2 (en) | 2004-08-04 |
| JP2005508181A (ja) | 2005-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2034 DE 29/12/2009. |