BR0212016A - Processo para produzir celulas dendrìticas maduras in vitro, método para produzir uma vacina para induzir uma resposta imune celular em um corpo humano ou animal, vacina e polìmero rna de fita dupla com alto peso molecular especificamente configurado - Google Patents

Processo para produzir celulas dendrìticas maduras in vitro, método para produzir uma vacina para induzir uma resposta imune celular em um corpo humano ou animal, vacina e polìmero rna de fita dupla com alto peso molecular especificamente configurado

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Publication number
BR0212016A
BR0212016A BR0212016-0A BR0212016A BR0212016A BR 0212016 A BR0212016 A BR 0212016A BR 0212016 A BR0212016 A BR 0212016A BR 0212016 A BR0212016 A BR 0212016A
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BR
Brazil
Prior art keywords
poly
vaccine
producing
dendritic cells
molecular weight
Prior art date
Application number
BR0212016-0A
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English (en)
Inventor
Malcolm Adams
Cyril Donninger
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Bioclones Proprietary Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bioclones Proprietary Ltd filed Critical Bioclones Proprietary Ltd
Publication of BR0212016A publication Critical patent/BR0212016A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PRODUZIR CéLULAS DENDRìTICAS MADURAS IN VITRO, MéTODO PARA PRODUZIR UMA VACINA PARA INDUZIR UMA RESPOSTA IMUNE CELULAR EM UM CORPO HUMANO OU ANIMAL, VACINA E POLìMERO RNA DE FITA DUPLA COM ALTO PESO MOLECULAR ESPECIFICAMENTE CONFIGURADO". A invenção provê um método para produzir células dendríticas maduras in vitro, o qual compreende a etapa de cultivar as células dendríticas imaturas em presença de um polímero RNA (dsRNA) de fita dupla de alto peso molecular especificamente configurado. O polímero dsRNA de alto peso molecular especificamente configurado é tipicamente selecionado do grupo compreendendo poli[I]:poli[CxU]; poli[I]:poli[GxU]; poli[A]: poli[UxC]; poli[A]:poli[UxG] poli[U]:poli[AxC]: poli[U]:poli[IxU]; poli[C]:poli[GxA]; poli[C]:poli[GxU]; poli[G]-polu[CXA]; poli[G]:poli[CxU] e Ampligen, onde x é uma proporção de um número de 3 a 40. As células dendríticas imaturas podem ser expostas a um antígeno antes que ele seja maturado, e uma vacina incluindo as células dendríticas maduras apresentando antígeno pode então ser preparada. Um método para tratar câncer, um vírus, um parasita e um microrganismo também é descrito.
BR0212016-0A 2001-08-08 2002-08-08 Processo para produzir celulas dendrìticas maduras in vitro, método para produzir uma vacina para induzir uma resposta imune celular em um corpo humano ou animal, vacina e polìmero rna de fita dupla com alto peso molecular especificamente configurado BR0212016A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119346.5A GB0119346D0 (en) 2001-08-08 2001-08-08 Process for the maturation of dendritic cells
PCT/IB2002/003116 WO2003014335A1 (en) 2001-08-08 2002-08-08 Process for the maturation of dentritic cells and a vaccine

Publications (1)

Publication Number Publication Date
BR0212016A true BR0212016A (pt) 2004-10-26

Family

ID=9920030

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212016-0A BR0212016A (pt) 2001-08-08 2002-08-08 Processo para produzir celulas dendrìticas maduras in vitro, método para produzir uma vacina para induzir uma resposta imune celular em um corpo humano ou animal, vacina e polìmero rna de fita dupla com alto peso molecular especificamente configurado

Country Status (14)

Country Link
US (1) US7981673B2 (pt)
EP (1) EP1417300B1 (pt)
JP (1) JP2004538000A (pt)
AT (1) ATE320481T1 (pt)
AU (1) AU2002324255B2 (pt)
BR (1) BR0212016A (pt)
CA (1) CA2457322C (pt)
DE (1) DE60209915T2 (pt)
DK (1) DK1417300T3 (pt)
ES (1) ES2263806T3 (pt)
GB (1) GB0119346D0 (pt)
MX (1) MXPA04001152A (pt)
WO (1) WO2003014335A1 (pt)
ZA (1) ZA200401842B (pt)

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EP2258712A3 (en) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
WO2005043155A1 (en) 2003-10-21 2005-05-12 Cedars-Sinai Medical Center System and method for the treatment of cancer, including cancers of the central nervous system
AU2013206335B2 (en) * 2005-12-07 2017-05-04 Hemispherx Biopharma, Inc. dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants
US7943147B2 (en) * 2005-12-07 2011-05-17 Hemispherx Biopharma dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants
CA2700573C (en) 2006-09-26 2016-11-22 Cedars-Sinai Medical Center Cancer stem cell antigen vaccines and methods
CA2700579A1 (en) 2006-09-28 2008-04-03 Cedars-Sinai Medical Center Cancer vaccines and vaccination methods
EP2134172A4 (en) * 2007-03-05 2011-06-01 Univ Utah State RESTRICTIVE AGONIST OF THE TOLL LIKE RECEPTOR 3
US9421254B2 (en) 2007-09-24 2016-08-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunostimulatory combinations of TLR ligands and methods of use
JP2011525169A (ja) * 2008-02-15 2011-09-15 へミスフェリックス・バイオファーマ，インコーポレーテッド Ｔｏｌｌ様受容体３の選択的アゴニスト
EP2281043B1 (en) * 2008-04-25 2013-03-13 Innate Pharma Improved tlr3 agonist compositions
EP2328923B1 (en) 2008-09-02 2016-01-13 Cedars-Sinai Medical Center Cd133 epitopes
EP2349288A4 (en) * 2008-10-10 2012-08-08 Hemispherx Biopharma Inc TREATMENT OF CHRONIC EXHAUST SYNDROME BY SELECTIVE TOLL LIKE RECEPTOR 3 (TLR3) AGONISTS
CA2741204A1 (en) * 2008-10-23 2010-04-29 Hemispherx Biopharma, Inc. Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
EP2427485B1 (en) 2009-05-07 2016-12-07 ImmunoCellular Therapeutics, Ltd. Cd133 epitopes
EP2956544B1 (en) 2013-02-14 2017-11-01 Immunocellular Therapeutics Ltd. Cancer vaccines and vaccination methods
SG10201911695SA (en) 2014-05-14 2020-01-30 Targimmune Therapeutics Ag Improved polyethyleneimine polyethyleneglycol vectors
WO2017152008A1 (en) 2016-03-04 2017-09-08 The Trustees Of Columbia University In The City Of New York Development of dual whole cell-based vaccine against pancreatic cancer
GB201711379D0 (en) * 2017-07-14 2017-08-30 Univ Cape Town Maturation of dendritic cells
KR20210006353A (ko) * 2018-05-04 2021-01-18 톨리스 상피 세포 및 골수 세포 모두를 활성화시키는 tlr3 리간드

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US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
US6080726A (en) * 1985-08-12 2000-06-27 University Of Maryland Anti-viral and immuno stimulator polynucleotide duplex and use thereof
WO1997022349A1 (en) * 1995-12-20 1997-06-26 The Board Of Trustees Of The Leland Stanford Junior University Methods for in vivo t cell activation by antigen-pulsed dendritic cells
WO2001080887A2 (en) * 2000-04-21 2001-11-01 Chemocentryx, Inc. Methods and chemokin compositions for inducing an immune response

Also Published As

Publication number Publication date
CA2457322A1 (en) 2003-02-20
DE60209915D1 (de) 2006-05-11
WO2003014335A1 (en) 2003-02-20
EP1417300B1 (en) 2006-03-15
CA2457322C (en) 2014-06-10
ES2263806T3 (es) 2006-12-16
US20040253722A1 (en) 2004-12-16
US7981673B2 (en) 2011-07-19
MXPA04001152A (es) 2005-02-17
EP1417300A1 (en) 2004-05-12
GB0119346D0 (en) 2001-10-03
AU2002324255B2 (en) 2007-06-07
ZA200401842B (en) 2005-05-25
DE60209915T2 (de) 2006-12-14
ATE320481T1 (de) 2006-04-15
JP2004538000A (ja) 2004-12-24
DK1417300T3 (da) 2006-07-17

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 39/00 (2006.01), C12N 5/0784 (2010.01), A61K