BR0211734A - Derivados do ácido 5,6,6a,11b-tetraidro- 7-oxa-5-aza- benzo [c] fluoreno-6-carboxìlico substituìdos como antagonistas do nmda - Google Patents

Derivados do ácido 5,6,6a,11b-tetraidro- 7-oxa-5-aza- benzo [c] fluoreno-6-carboxìlico substituìdos como antagonistas do nmda

Info

Publication number
BR0211734A
BR0211734A BR0211734-7A BR0211734A BR0211734A BR 0211734 A BR0211734 A BR 0211734A BR 0211734 A BR0211734 A BR 0211734A BR 0211734 A BR0211734 A BR 0211734A
Authority
BR
Brazil
Prior art keywords
aza
oxa
benzo
tetrahydro
carboxylic acid
Prior art date
Application number
BR0211734-7A
Other languages
English (en)
Inventor
Matthias Gerlach
Michael Przewosny
Werner Gunter Englberger
Elke Reissmuller
Petra Bloms-Funke
Corinna Maul
Utz-Peter Jagusch
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR0211734A publication Critical patent/BR0211734A/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P27/16—Otologicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"DERIVADOS DO áCIDO 5,6,6a,11b-TETRAIDRO- 7-OXA-5-AZA- BENZO [C] FLUORENO-6-CARBOXìLICO SUBSTITUìDOS COMO ANTAGONISTAS DO NMDA". A presente invenção está relacionada com derivados do ácido 5,6,6a, 11b-tetraidro- 7-oxa-5-aza- benzo[c] fluoreno-6- carboxílico substituídos, bem como com um procedimento para sua elaboração, medicamentos que contêm estes compostos e seu uso a fim de elaborar medicamentos para determinadas indicações, em particular, para o tratamento da dor.
BR0211734-7A 2001-08-03 2002-08-05 Derivados do ácido 5,6,6a,11b-tetraidro- 7-oxa-5-aza- benzo [c] fluoreno-6-carboxìlico substituìdos como antagonistas do nmda BR0211734A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137487A DE10137487A1 (de) 2001-08-03 2001-08-03 Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
PCT/EP2002/008886 WO2003014124A1 (de) 2001-08-03 2002-08-05 SUBSTITUIERTE 5,6,6a,11b-TETRAHYDRO-7-OXA-5-AZA-BENZO'C!FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN

Publications (1)

Publication Number Publication Date
BR0211734A true BR0211734A (pt) 2004-09-21

Family

ID=7693857

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211734-7A BR0211734A (pt) 2001-08-03 2002-08-05 Derivados do ácido 5,6,6a,11b-tetraidro- 7-oxa-5-aza- benzo [c] fluoreno-6-carboxìlico substituìdos como antagonistas do nmda

Country Status (21)

Country Link
US (1) US7199130B2 (pt)
EP (1) EP1412361B1 (pt)
JP (1) JP2005500374A (pt)
KR (1) KR20040020078A (pt)
CN (1) CN1697836A (pt)
AT (1) ATE402178T1 (pt)
BR (1) BR0211734A (pt)
CA (1) CA2456124A1 (pt)
CO (1) CO5550438A2 (pt)
DE (2) DE10137487A1 (pt)
EC (1) ECSP044968A (pt)
ES (1) ES2310211T3 (pt)
HU (1) HUP0400800A3 (pt)
IL (1) IL160160A0 (pt)
MX (1) MXPA04000953A (pt)
NO (1) NO20040471L (pt)
NZ (1) NZ531372A (pt)
PL (1) PL368073A1 (pt)
RU (1) RU2004106533A (pt)
WO (1) WO2003014124A1 (pt)
ZA (1) ZA200401725B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10304950A1 (de) * 2003-02-06 2004-08-19 Grünenthal GmbH Herstellung von Tetrahydrochinolinbenzofuranen
KR20050021629A (ko) * 2003-08-25 2005-03-07 학교법인 이화학당 신규한 벤조플루오렌 디온계 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839B1 (en) * 1989-03-08 1997-01-15 Merck Sharp & Dohme Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
DE19536809A1 (de) * 1995-10-02 1997-04-03 Basf Ag Heterocyclisch substituierte Salicylsäurederivate
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate

Also Published As

Publication number Publication date
EP1412361A1 (de) 2004-04-28
ATE402178T1 (de) 2008-08-15
KR20040020078A (ko) 2004-03-06
WO2003014124A1 (de) 2003-02-20
RU2004106533A (ru) 2005-07-27
ES2310211T3 (es) 2009-01-01
EP1412361B1 (de) 2008-07-23
NZ531372A (en) 2005-03-24
JP2005500374A (ja) 2005-01-06
US20040248889A1 (en) 2004-12-09
CN1697836A (zh) 2005-11-16
IL160160A0 (en) 2004-07-25
DE10137487A1 (de) 2003-03-27
CO5550438A2 (es) 2005-08-31
CA2456124A1 (en) 2003-02-20
ECSP044968A (es) 2004-03-23
HUP0400800A3 (en) 2007-09-28
PL368073A1 (en) 2005-03-21
US7199130B2 (en) 2007-04-03
NO20040471L (no) 2004-02-02
HUP0400800A2 (hu) 2004-07-28
DE50212538D1 (de) 2008-09-04
MXPA04000953A (es) 2004-04-20
ZA200401725B (en) 2005-01-31

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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