BR0207438A - Novos derivados de 5-ciano-1h-indol antagonista dos receptores da interleucina-8 - Google Patents

Novos derivados de 5-ciano-1h-indol antagonista dos receptores da interleucina-8

Info

Publication number
BR0207438A
BR0207438A BR0207438-9A BR0207438A BR0207438A BR 0207438 A BR0207438 A BR 0207438A BR 0207438 A BR0207438 A BR 0207438A BR 0207438 A BR0207438 A BR 0207438A
Authority
BR
Brazil
Prior art keywords
cyano
indole derivatives
receptor antagonist
novel interleukin
solvents
Prior art date
Application number
BR0207438-9A
Other languages
English (en)
Inventor
Martine Barth
Pierre Dodey
Jean-Luc Paquet
Original Assignee
Fournier Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Publication of BR0207438A publication Critical patent/BR0207438A/pt

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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
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  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"NOVOS DERIVADOS DE 5-CIANO-1H-INDOL ANTAGONISTAS DOS RECEPTORES DA INTERLEUCINA-8". A presente invenção se refere aos derivados de 5-ciano-1H-indol de fórmula (I): na qual R~ 1~, R~ 2~, X e n são tais como definidos na reivindicação 1, assim como seus sais, solventes e hidratos farmaceuticamente aceitáveis. A invenção tem igualmente por objeto as composições farmacêuticas os contendo, assim como sua utilização para a preparação de medicamentos destinados ao tratamento preventivo ou curativo das doenças dependentes da ativação do receptor CXCR2 da interleucina-8 e das quimiocinas da mesma família.
BR0207438-9A 2001-05-17 2002-05-16 Novos derivados de 5-ciano-1h-indol antagonista dos receptores da interleucina-8 BR0207438A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106506A FR2824826B1 (fr) 2001-05-17 2001-05-17 Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8
PCT/FR2002/001647 WO2002092568A1 (fr) 2001-05-17 2002-05-16 Derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8

Publications (1)

Publication Number Publication Date
BR0207438A true BR0207438A (pt) 2004-08-10

Family

ID=8863389

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207438-9A BR0207438A (pt) 2001-05-17 2002-05-16 Novos derivados de 5-ciano-1h-indol antagonista dos receptores da interleucina-8

Country Status (10)

Country Link
US (1) US20050100902A1 (pt)
EP (1) EP1390348A1 (pt)
JP (1) JP2004534034A (pt)
KR (1) KR20030094255A (pt)
CN (1) CN1496348A (pt)
BR (1) BR0207438A (pt)
CA (1) CA2447184A1 (pt)
CZ (1) CZ20032260A3 (pt)
FR (1) FR2824826B1 (pt)
WO (1) WO2002092568A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
GB0515025D0 (en) * 2005-07-21 2005-08-31 Novartis Ag Organic compounds
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
KR20220151634A (ko) 2020-03-06 2022-11-15 버텍스 파마슈티칼스 인코포레이티드 Apol-1 의존성 국소 분절성 사구체경화증을 치료하는 방법
AU2021286666A1 (en) * 2020-06-12 2023-01-19 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and use of the same
CA3190609A1 (en) 2020-08-26 2022-03-03 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4514496A (en) * 1994-12-13 1996-07-03 Smithkline Beecham Corporation Novel compounds
GB9905010D0 (en) * 1999-03-04 1999-04-28 Merck Sharp & Dohme Therapeutic agents
FR2801585B1 (fr) * 1999-11-25 2002-02-15 Fournier Ind & Sante Nouveaux antagonistes des recepteurs de l'ii-8

Also Published As

Publication number Publication date
CN1496348A (zh) 2004-05-12
FR2824826B1 (fr) 2003-11-07
WO2002092568A1 (fr) 2002-11-21
CZ20032260A3 (cs) 2003-11-12
FR2824826A1 (fr) 2002-11-22
CA2447184A1 (fr) 2002-11-21
EP1390348A1 (fr) 2004-02-25
US20050100902A1 (en) 2005-05-12
JP2004534034A (ja) 2004-11-11
KR20030094255A (ko) 2003-12-11

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B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]