BR0207037A - Estruturas de polinucleotìdeos para melhorar a produção de lisina - Google Patents

Estruturas de polinucleotìdeos para melhorar a produção de lisina

Info

Publication number
BR0207037A
BR0207037A BR0207037-5A BR0207037A BR0207037A BR 0207037 A BR0207037 A BR 0207037A BR 0207037 A BR0207037 A BR 0207037A BR 0207037 A BR0207037 A BR 0207037A
Authority
BR
Brazil
Prior art keywords
lysine production
dapb
ask
asd
ddh
Prior art date
Application number
BR0207037-5A
Other languages
English (en)
Other versions
BRPI0207037B1 (pt
Inventor
Lhing-Yew Li
Kelly Jean Trei
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Publication of BR0207037A publication Critical patent/BR0207037A/pt
Publication of BRPI0207037B1 publication Critical patent/BRPI0207037B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"ESTRUTURAS DE POLINUCLEOTìDEOS PARA MELHORAR A PRODUçãO DE LISINA". A invenção está relacionada à produção de lisina e fornece diversas moléculas de polinucleotídeos isoladas úteis para a produção de L-lisina. Um desses polinucleotídeos codifica uma aspartatoquinase (ask ), uma aspartato-semialdeído desidrogenase (asd) e uma diidrodipicolinato redutase (dapB). Outros polipeptídeos codificam ask, dapB e uma diaminopimelato desidrogenase (ddh); ask, asd, dapB, ddh e um polipeptídeo ORF2; e ask, asd dapB, ddh, ORF2 e uma diaminopimelato descarboxilase (lis A). A invenção também fornece métodos de produção e fabricação dos polinucleotídeos e métodos para melhorar a produção da L-lisina.
BRPI0207037-5A 2001-02-08 2002-02-08 Construção sintética de polinucleotídeos para melhorar a produção de lisina, vetor, bactéria transformada, métodos para transformar uma bactéria e método de produção de lisina BRPI0207037B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26718301P 2001-02-08 2001-02-08
PCT/US2002/003469 WO2002064610A1 (en) 2001-02-08 2002-02-08 Polynucleotide constructs for increased lysine production

Publications (2)

Publication Number Publication Date
BR0207037A true BR0207037A (pt) 2004-06-22
BRPI0207037B1 BRPI0207037B1 (pt) 2015-07-07

Family

ID=23017664

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0207037-5A BRPI0207037B1 (pt) 2001-02-08 2002-02-08 Construção sintética de polinucleotídeos para melhorar a produção de lisina, vetor, bactéria transformada, métodos para transformar uma bactéria e método de produção de lisina

Country Status (9)

Country Link
EP (1) EP1368367B1 (pt)
AR (1) AR032570A1 (pt)
BR (1) BRPI0207037B1 (pt)
CA (1) CA2437656C (pt)
IL (2) IL156997A0 (pt)
MX (1) MXPA03007089A (pt)
NO (1) NO20033452L (pt)
NZ (1) NZ527129A (pt)
WO (1) WO2002064610A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102233376B1 (ko) * 2019-09-26 2021-03-30 씨제이제일제당 주식회사 메조 디아미노피멜레이트 디하이드로게네이즈 변이형 폴리펩타이드 및 이를 이용한 l-쓰레오닌 생산방법
CN116042416A (zh) * 2023-01-09 2023-05-02 天津科技大学 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045451B (it) 1966-03-23 1980-05-10 Ajinomoto Kk Metodo per recuperare lisina da brodo di fermentazione
JPS56160997A (en) 1980-05-16 1981-12-11 Ajinomoto Co Inc Preparation of l-lysine by fermenaition method
US5236831A (en) 1981-12-29 1993-08-17 Kiowa Hakko Kogyo Co., Ltd. Amino acid synthesis in corynebacteria using E. coli genes
JPH06102028B2 (ja) 1985-10-04 1994-12-14 協和醗酵工業株式会社 アミノ酸の製造法
DE3908201A1 (de) * 1989-03-14 1990-09-27 Degussa Verfahren zur fermentativen herstellung von l-lysin
JPH07155184A (ja) * 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
CN1117152C (zh) 1994-03-04 2003-08-06 味之素株式会社 生产l－赖氨酸的方法
AU705550B2 (en) * 1995-06-07 1999-05-27 Ajinomoto Co., Inc. Method of producing L-lysine
JP4035855B2 (ja) 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
CN100540668C (zh) 1999-04-19 2009-09-16 协和发酵生化株式会社 新型脱敏型天冬氨酸激酶
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria

Also Published As

Publication number Publication date
CA2437656C (en) 2009-06-30
IL156997A (en) 2014-08-31
NZ527129A (en) 2005-05-27
EP1368367B1 (en) 2017-05-03
EP1368367A1 (en) 2003-12-10
BRPI0207037B1 (pt) 2015-07-07
EP1368367A4 (en) 2004-09-01
NO20033452L (no) 2003-10-07
CA2437656A1 (en) 2002-08-22
AR032570A1 (es) 2003-11-12
IL156997A0 (en) 2004-02-08
WO2002064610A1 (en) 2002-08-22
MXPA03007089A (es) 2004-10-15
NO20033452D0 (no) 2003-08-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12N 15/53 (2006.01), C12N 15/09 (2006.01), C12N 1

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/07/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2500 DE 04-12-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.