BR0204489A

BR0204489A - Rhodamine derivatives, compound, intermediates, rhodamine derivative synthesis processes, use of a compound, methods for photodynamic therapy of patients, in vitro purification of human bone marrow, treatment of leukemia, immunological disorders and bacterial infections and disease prevention, photoactivable pharmaceutical composition, bactericidal composition and solution and medicament.

Info

Publication number: BR0204489A
Application number: BR0204489-7A
Authority: BR
Inventors: Abdelkrim Habi; Denis Gravel; Luc Villeneuve; Hongsheng Su; Marc Vaillancourt
Original assignee: Theratechnologies Inc
Priority date: 2001-04-02
Filing date: 2002-03-27
Publication date: 2003-04-01
Also published as: BRPI0204489B1; JP2004518766A; BRPI0204489B8; WO2002079183A8; MXPA02011638A; WO2002079183A1; JP2011006421A; JP5277211B2; EP1276734A1; JP4647187B2

Abstract

"DERIVADOS DE RODAMINA, COMPOSTO, INTERMEDIáRIOS, PROCESSOS PARA A SìNTESE DE DERIVADOS DE RODAMINA, USO DE UM COMPOSTO, MéTODOS PARA A TERAPIA FOTODINâMICA DE PACIENTES, PARA PURGA IN VITRO DA MEDULA óSSEA HUMANA, PARA O TRATAMENTO DE LEUCEMIAS, DE DISTúRBIO IMUNOLóGICO E DE INFECçõES GERADAS POR BACTéRIAS E PARA PREVENçãO DE DOENçA, COMPOSIçãO FARMACêUTICA FOTOATIVáVEL COMPOSIçãO E SOLUçãO BACTERICIDA E MEDICAMENTO". Novos compostos de fórmula (I) em que: um de R1, R2, R3, R4 e (R10)n representa um átomo de halogêneo e cada um dos restantes R1, R2, R3, R4 e cada um do grupo R10 remanescente é independentemente selecionado do grupo constituído por hidrogênio, átomos de halogêneo, um grupo amino, acilamino, dialquilamino, cicloalquilamino, azacicloalquila, alquilcicloalquilamino, aroilamino, diarilamino, arilalquilamino, aralquilamino, alquilaralquilamino, arilaralquilamino, hidróxi, alcóxi, arilóxi, aralquilóxi, mercapto, alquiltio, ariltio, aralquiltio, carboxila, alcoxicarbonila, ariloxicarbonila, aralcoxicarbonila, carbamoíla, alquilcarbamoíla, dialquilcarbamoíla, ciano, hidroxissulfonila, amidossulfonila, dialquilamidossulfonila, arilalquilamidossulfonila, formila, acila, aroíla, alquila, alquileno, alquenila, arila, aralquila, vinila, alquinila e pelos correspondentes grupos substituídos: m=0-1; n=1-4, A é nada, O ou NH; R9 representa um grupo alquileno; - Z -e H, sal amino, dialquilamino ou trialquilamino; X- é um ânion; R5, R6, R7 e R8 são independentemente H ou C1-C6 alquila ou R1, em combinação com R5 ou R6, ou R2, em Combinação com R7 ou R8, ou R4, em combinação com R7 ou R8, representa um alquileno, sozinho ou em associação com um veículo farmaceuticamente aceitável. Estes compostos, que são úteis como intermediários e como bactericidas, como agente antiviral e no tratamento de distúrbios imunológicos"RODAMINE DERIVATIVES, COMPOUND, INTERMEDIATE, PROCESSES FOR SYNTHESIS OF RODAMINE DERIVATIVES, USE OF A COMPOUND, METHODS FOR PHOTODYNAMIC THERAPY FOR PATIENTS, FOR IN VITRO PURGUATION OF THE HUMAN BONE MEDICINE, AND THE DUCUMOUS DISTURAL BACTERIA GENERATED INFECTIONS AND DISEASE PREVENTION, PHOTOACTIVE PHARMACEUTICAL COMPOSITION BACTERICIDE COMPOSITION AND SOLUTION ". Novel compounds of formula (I) wherein: one of R1, R2, R3, R4 and (R10) n represents a halogen atom and each of the remaining R1, R2, R3, R4 and each of the remaining group R10 is independently selected from the group consisting of hydrogen, halogen atoms, an amino group, acylamino, dialkylamino, cycloalkylamino, azacycloalkyl, alkylcycloalkylamino, aroylamino, diarylamino, arylalkylamino, aralkylamino, arylalkylamino, arylalkyloxy, arylalkylamino, arylalkylamino aralkylthio, carboxyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, hydroxysulfonyl, amylsulfonyl, arylalkylamylsulfonyl, arylalkyl, arylalkyl, alkyl, arylalkyl, alkyl, arylalkyl, alkyl, arylalkyl, arylalkyl, alkyl, arylalkyl substituted: m = 0-1; n = 1-4, A is nothing, O or NH; R 9 represents an alkylene group; Z is H, amino, dialkylamino or trialkylamino salt; X- is an anion; R5, R6, R7 and R8 are independently H or C1-C6 alkyl or R1 in combination with R5 or R6 or R2 in combination with R7 or R8 or R4 in combination with R7 or R8 represents an alkylene alone or in combination with a pharmaceutically acceptable carrier. These compounds, which are useful as intermediates and as bactericides, as an antiviral agent and in the treatment of immune disorders.