BRPI0204489B8 - "Rhodamine derivative, pharmaceutical composition, intermediate, and, process for the synthesis of new rhodamine derivatives". - Google Patents
"Rhodamine derivative, pharmaceutical composition, intermediate, and, process for the synthesis of new rhodamine derivatives".Info
- Publication number
- BRPI0204489B8 BRPI0204489B8 BRPI0204489A BR0204489A BRPI0204489B8 BR PI0204489 B8 BRPI0204489 B8 BR PI0204489B8 BR PI0204489 A BRPI0204489 A BR PI0204489A BR 0204489 A BR0204489 A BR 0204489A BR PI0204489 B8 BRPI0204489 B8 BR PI0204489B8
- Authority
- BR
- Brazil
- Prior art keywords
- group
- combination
- alkylene
- rhodamine
- synthesis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"derivados de rodamina, composto, intermediários, processos para a síntese de derivados de rodamina, uso de um composto, métodos para a terapia fotodinâmica de pacientes, para purga in vitro da medula óssea humana, para o tratamento de leucemias, de distúrbio imunológico e de infecções geradas por bactérias e para prevenção de doença, composição farmacêutica fotoativável composição e solução bactericida e medicamento". novos compostos de fórmula (i) em que: um de r1, r2, r3, r4 e (r10)n representa um átomo de halogêneo e cada um dos restantes r1, r2, r3, r4 e cada um do grupo r10 remanescente é independentemente selecionado do grupo constituído por hidrogênio, átomos de halogêneo, um grupo amino, acilamino, dialquilamino, cicloalquilamino, azacicloalquila, alquilcicloalquilamino, aroilamino, diarilamino, arilalquilamino, aralquilamino, alquilaralquilamino, arilaralquilamino, hidróxi, alcóxi, arilóxi, aralquilóxi, mercapto, alquiltio, ariltio, aralquiltio, carboxila, alcoxicarbonila, ariloxicarbonila, aralcoxicarbonila, carbamoíla, alquilcarbamoíla, dialquilcarbamoíla, ciano, hidroxissulfonila, amidossulfonila, dialquilamidossulfonila, arilalquilamidossulfonila, formila, acila, aroíla, alquila, alquileno, alquenila, arila, aralquila, vinila, alquinila e pelos correspondentes grupos substituídos: m=0-1; n=1-4, a é nada, o ou nh; r9 representa um grupo alquileno; - z -e h, sal amino, dialquilamino ou trialquilamino; x- é um ânion; r5, r6, r7 e r8 são independentemente h ou c1-c6 alquila ou r1, em combinação com r5 ou r6, ou r2, em combinação com r7 ou r8, ou r4, em combinação com r7 ou r8, representa um alquileno, sozinho ou em associação com um veículo farmaceuticamente aceitável. estes compostos, que são úteis como intermediários e como bactericidas, como agente antiviral e no tratamento de distúrbios imunológicos"rhodamine derivatives, compound, intermediates, processes for the synthesis of rhodamine derivatives, use of a compound, methods for photodynamic therapy of patients, for in vitro purging of human bone marrow, for the treatment of leukemia, of immunological disorder and of infections generated by bacteria and for disease prevention, photoactivatable pharmaceutical composition, composition and bactericidal solution and medicine". novel compounds of formula (I) wherein: one of r1, r2, r3, r4 and (r10)n represents a halogen atom and each of the remaining r1, r2, r3, r4 and each of the remaining r10 group is independently selected from the group consisting of hydrogen, halogen atoms, an amino group, acylamino, dialkylamino, cycloalkylamino, azacycloalkyl, alkylcycloalkylamino, aroylamino, diarylamino, arylalkylamino, aralkylamino, alkylaralkylamino, arylaralkylamino, hydroxy, alkoxy, aryloxy, aralkyloxy, arylthio, arylthio, aryloxy , aralkylthio, carboxyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, cyano, hydroxysulfonyl, amidosulfonyl, dialkylamidosulfonyl, arylalkylamidosulfonyl, formyl, acyl, acyl, aroyl, aralkylene, aryl, alkylene, and corresponding aroyl, alkylalkenyl and alkyl groups substituted: m=0-1; n=1-4, a is nothing, o or nh; R9 represents an alkylene group; - z -e h, amino, dialkylamino or trialkylamino salt; x- is an anion; r5, r6, r7 and r8 are independently h or c1-c6 alkyl or r1 in combination with r5 or r6, or r2 in combination with r7 or r8, or r4 in combination with r7 or r8 represents an alkylene alone or in association with a pharmaceutically acceptable carrier. these compounds, which are useful as intermediates and as bactericides, as an antiviral agent and in the treatment of immunological disorders.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82222301A | 2001-04-02 | 2001-04-02 | |
| CA002342675A CA2342675A1 (en) | 2001-04-02 | 2001-04-02 | Halogenated rhodamine derivatives and applications thereof |
| PCT/CA2002/000438 WO2002079183A1 (en) | 2001-04-02 | 2002-03-27 | Halogenated rhodamine derivatives and applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0204489A BR0204489A (en) | 2003-04-01 |
| BRPI0204489B1 BRPI0204489B1 (en) | 2017-05-30 |
| BRPI0204489B8 true BRPI0204489B8 (en) | 2021-05-25 |
Family
ID=25682483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0204489A BRPI0204489B8 (en) | 2001-04-02 | 2002-03-27 | "Rhodamine derivative, pharmaceutical composition, intermediate, and, process for the synthesis of new rhodamine derivatives". |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1276734A1 (en) |
| JP (2) | JP4647187B2 (en) |
| BR (1) | BRPI0204489B8 (en) |
| MX (1) | MXPA02011638A (en) |
| WO (1) | WO2002079183A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005053743A1 (en) * | 2003-12-05 | 2005-06-16 | Université de Montréal | Immunologic compounds for prevention, protection, prophylaxis or treatment of immunological disorders, infections and cancer |
| ES2799892T3 (en) * | 2008-12-10 | 2020-12-22 | Wista Lab Ltd | 3,6-disubstituted xanthilium salts |
| RU2527519C2 (en) * | 2010-06-24 | 2014-09-10 | Общество С Ограниченной Ответственностью "Митотех" | Mild cationic mitochondrial uncouplers |
| CN103183657A (en) * | 2011-12-31 | 2013-07-03 | 中国科学院成都有机化学有限公司 | Synthesis method of rhodamine esterification derivative |
| EP3058957A1 (en) | 2015-02-19 | 2016-08-24 | Kiadis Pharma Intellectual Property BV | Improved photodynamic process and product obtained therefrom |
| CN106632215B (en) * | 2016-11-17 | 2019-04-12 | 陕西师范大学 | A kind of fluorescence protein coloring agent and its preparation method and application |
| US11560365B2 (en) | 2018-03-02 | 2023-01-24 | The University Of Tokyo | Non-fluorescent rhodamines |
| JP7307653B2 (en) | 2018-11-26 | 2023-07-12 | 保土谷化学工業株式会社 | Xanthene dye, coloring composition containing the dye, colorant for color filter, and color filter |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2421607A1 (en) * | 1974-05-04 | 1975-11-13 | Bayer Ag | DYE LASER |
| US4651739A (en) * | 1985-04-08 | 1987-03-24 | The General Hospital Corporation | Light-induced killing of carcinoma cells |
| WO1987006138A1 (en) * | 1986-04-11 | 1987-10-22 | President And Fellows Of Harvard College | Dihydrorhodamines and halogenated derivatives thereof |
| FR2613626B1 (en) * | 1987-04-07 | 1990-12-14 | Bbc Brown Boveri & Cie | METHOD AND DEVICE FOR DISINFECTING UTENSILS |
| US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| US5556992A (en) * | 1994-09-02 | 1996-09-17 | Universite De Montreal | Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias |
| CA2231114A1 (en) * | 1995-09-06 | 1997-03-13 | The Research Foundation Of State University Of New York | Two-photon upconverting dyes and applications |
| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US6130101A (en) * | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| WO2000017650A1 (en) * | 1998-09-23 | 2000-03-30 | Molecular Probes, Inc. | Energy transfer compositions comprising phycobiliproteins |
| DE60017201T2 (en) * | 1999-10-05 | 2005-12-29 | Université de Montreal, Montreal | Rhodamine derivatives for the photodynamic diagnosis and treatment |
-
2002
- 2002-03-27 BR BRPI0204489A patent/BRPI0204489B8/en not_active IP Right Cessation
- 2002-03-27 MX MXPA02011638A patent/MXPA02011638A/en active IP Right Grant
- 2002-03-27 WO PCT/CA2002/000438 patent/WO2002079183A1/en not_active Application Discontinuation
- 2002-03-27 EP EP02708105A patent/EP1276734A1/en not_active Withdrawn
- 2002-03-27 JP JP2002577810A patent/JP4647187B2/en not_active Expired - Fee Related
-
2010
- 2010-07-12 JP JP2010157390A patent/JP5277211B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002079183A8 (en) | 2003-02-20 |
| JP2011006421A (en) | 2011-01-13 |
| WO2002079183A1 (en) | 2002-10-10 |
| JP5277211B2 (en) | 2013-08-28 |
| EP1276734A1 (en) | 2003-01-22 |
| JP2004518766A (en) | 2004-06-24 |
| MXPA02011638A (en) | 2003-05-14 |
| BR0204489A (en) | 2003-04-01 |
| BRPI0204489B1 (en) | 2017-05-30 |
| JP4647187B2 (en) | 2011-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: CELMED BIOSCIENCES INC. (CA) |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/03/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
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| B21H | Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2715 DE 17/01/2023 POR TER SIDO INDEVIDA. |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 27/03/2022 |