BR0116723A - Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina - Google Patents

Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Info

Publication number
BR0116723A
BR0116723A BR0116723-5A BR0116723A BR0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A
Authority
BR
Brazil
Prior art keywords
acetic acid
thioester derivatives
preparation
acid thioester
cephalosporin compounds
Prior art date
Application number
BR0116723-5A
Other languages
English (en)
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Original Assignee
Orchid Chemicals & Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd filed Critical Orchid Chemicals & Pharm Ltd
Publication of BR0116723A publication Critical patent/BR0116723A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE TIOéSTER DE áCIDO TIAZOLIL ACéTICO E SEU USO NA PREPARAçãO DE COMPOSTOS DE CEFALOSPORINA". A presente invenção refere-se a derivados de tioéster de ácido tiazolil acético da fórmula geral (I), também, a invenção proporciona um método de preparação dos derivados de tioéster e reação dos derivados de tioéster com ácido cefem carboxílicos para produzir compostos antibióticos de cefalosporina tendo a fórmula geral (II).
BR0116723-5A 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina BR0116723A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/754,302 US6388070B1 (en) 2001-01-05 2001-01-05 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
PCT/IN2001/000028 WO2002053563A1 (en) 2001-01-05 2001-02-28 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Publications (1)

Publication Number Publication Date
BR0116723A true BR0116723A (pt) 2005-02-01

Family

ID=25034204

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116723-5A BR0116723A (pt) 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Country Status (8)

Country Link
US (2) US6388070B1 (pt)
EP (1) EP1347970A1 (pt)
JP (1) JP2004520336A (pt)
KR (1) KR20030078882A (pt)
CN (1) CN1492867A (pt)
BR (1) BR0116723A (pt)
CA (1) CA2433783A1 (pt)
WO (1) WO2002053563A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302015B6 (cs) 1999-10-08 2010-09-08 Affinium Pharmaceuticals, Inc. Inhibitory Fab I
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
US6713625B2 (en) * 2002-05-23 2004-03-30 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of cefditoren using the thioester of thiazolylacetic acid
DE60336331D1 (de) * 2002-08-13 2011-04-21 Sandoz Ag Ein cefdinir-zwischenprodukt
ATE373667T1 (de) * 2002-10-29 2007-10-15 Lupin Ltd Verfahren zur herstellung von ceftiofur
AU2003276525A1 (en) * 2002-11-15 2004-06-15 Orchid Chemicals And Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
AU2003282267A1 (en) * 2002-11-22 2004-06-18 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
EP1608377B1 (en) * 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
JPWO2004085443A1 (ja) * 2003-03-24 2006-06-29 ア・チ・エツセ・ドブフアル・エツセ・ピー・アー ７−［２−（２−アミノチアゾール−４−イル）−２−ヒドロキシイミノアセトアミド−３−ビニル−３−セフェム−４−カルボン酸（シン異性体）の新規結晶およびその製造方法
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060029674A1 (en) * 2004-04-09 2006-02-09 Sever Nancy E Stable amorphous Cefdinir
WO2005105813A1 (en) * 2004-04-28 2005-11-10 Wockhardt Limited Improved process for the manufacture of ceftriaxone sodium
PT1828167E (pt) 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
US7705142B2 (en) 2005-03-29 2010-04-27 Hetero Drugs Limited Process for the preparation of cefixime
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) * 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
TR201909016T4 (tr) 2012-06-19 2019-07-22 Debiopharm Int Sa (E)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamidin ön ilaç türevleri.
CN104876948A (zh) * 2015-05-28 2015-09-02 华北制药河北华民药业有限责任公司 一种头孢曲松钠的制备方法
DK3419628T3 (da) 2016-02-26 2021-01-11 Debiopharm Int Sa Medikament til behandling af diabetiske fodinfektioner
CN107955021A (zh) * 2017-10-27 2018-04-24 苏州盖德精细材料有限公司 一种低杂质的头孢曲松钠的生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
IN184690B (pt) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
US6555680B1 (en) * 2001-12-10 2003-04-29 Orchid Chemicals & Pharmaceuticals Ltd. Method for the preparation of ceftiofur sodium
US6610845B1 (en) * 2002-01-04 2003-08-26 Orchid Chemicals & Pharmaceuticals Limited, India Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Also Published As

Publication number Publication date
JP2004520336A (ja) 2004-07-08
KR20030078882A (ko) 2003-10-08
CA2433783A1 (en) 2002-07-11
US6388070B1 (en) 2002-05-14
EP1347970A1 (en) 2003-10-01
US20040087787A1 (en) 2004-05-06
WO2002053563A1 (en) 2002-07-11
CN1492867A (zh) 2004-04-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A., E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.