BR0116723A - Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina - Google Patents

Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Info

Publication number
BR0116723A
BR0116723A BR0116723-5A BR0116723A BR0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A
Authority
BR
Brazil
Prior art keywords
acetic acid
thioester derivatives
preparation
acid thioester
cephalosporin compounds
Prior art date
Application number
BR0116723-5A
Other languages
English (en)
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Original Assignee
Orchid Chemicals & Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd filed Critical Orchid Chemicals & Pharm Ltd
Publication of BR0116723A publication Critical patent/BR0116723A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE TIOéSTER DE áCIDO TIAZOLIL ACéTICO E SEU USO NA PREPARAçãO DE COMPOSTOS DE CEFALOSPORINA". A presente invenção refere-se a derivados de tioéster de ácido tiazolil acético da fórmula geral (I), também, a invenção proporciona um método de preparação dos derivados de tioéster e reação dos derivados de tioéster com ácido cefem carboxílicos para produzir compostos antibióticos de cefalosporina tendo a fórmula geral (II).
BR0116723-5A 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina BR0116723A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/754,302 US6388070B1 (en) 2001-01-05 2001-01-05 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
PCT/IN2001/000028 WO2002053563A1 (en) 2001-01-05 2001-02-28 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Publications (1)

Publication Number Publication Date
BR0116723A true BR0116723A (pt) 2005-02-01

Family

ID=25034204

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116723-5A BR0116723A (pt) 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Country Status (8)

Country Link
US (2) US6388070B1 (pt)
EP (1) EP1347970A1 (pt)
JP (1) JP2004520336A (pt)
KR (1) KR20030078882A (pt)
CN (1) CN1492867A (pt)
BR (1) BR0116723A (pt)
CA (1) CA2433783A1 (pt)
WO (1) WO2002053563A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60017180T2 (de) * 1999-10-08 2005-12-08 Affinium Pharmaceuticals, Inc., Toronto Fab i inhibitoren
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
US7049310B2 (en) * 2001-04-06 2006-05-23 Affinium Pharmaceuticals, Inc. Fab I inhibitors
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
WO2003099826A1 (en) * 2002-05-23 2003-12-04 Orchid Chemicals And Pharmaceuticals Limited A new process for the preparation of cefditoren using the thioester of thiazolylacetic acid
AU2003255424A1 (en) * 2002-08-13 2004-03-03 Sandoz Ag A cefdinir intermediate
DE60316459T2 (de) * 2002-10-29 2008-06-19 Lupin Ltd., Mumbai Verfahren zur herstellung von ceftiofur
WO2004046154A1 (en) * 2002-11-15 2004-06-03 Orchid Chemicals & Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
WO2004048387A1 (en) * 2002-11-22 2004-06-10 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
CA2508792C (en) * 2002-12-06 2013-02-05 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
EP1608377B1 (en) * 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
CN100357294C (zh) * 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060029674A1 (en) * 2004-04-09 2006-02-09 Sever Nancy E Stable amorphous Cefdinir
WO2005105813A1 (en) * 2004-04-28 2005-11-10 Wockhardt Limited Improved process for the manufacture of ceftriaxone sodium
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
DE602005017197D1 (de) 2005-03-29 2009-11-26 Hetero Drugs Ltd Verbessertes verfahren zur herstellung von cefixim
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
IN2014KN02915A (pt) 2012-06-19 2015-05-08 Debiopharm Int Sa
CN104876948A (zh) * 2015-05-28 2015-09-02 华北制药河北华民药业有限责任公司 一种头孢曲松钠的制备方法
ES2842443T3 (es) 2016-02-26 2021-07-14 Debiopharm Int Sa Medicamento para el tratamiento de infecciones del pie diabético
CN107955021A (zh) * 2017-10-27 2018-04-24 苏州盖德精细材料有限公司 一种低杂质的头孢曲松钠的生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
IN184690B (pt) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
US6555680B1 (en) * 2001-12-10 2003-04-29 Orchid Chemicals & Pharmaceuticals Ltd. Method for the preparation of ceftiofur sodium
US6610845B1 (en) * 2002-01-04 2003-08-26 Orchid Chemicals & Pharmaceuticals Limited, India Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Also Published As

Publication number Publication date
CN1492867A (zh) 2004-04-28
CA2433783A1 (en) 2002-07-11
WO2002053563A1 (en) 2002-07-11
EP1347970A1 (en) 2003-10-01
US6388070B1 (en) 2002-05-14
US20040087787A1 (en) 2004-05-06
KR20030078882A (ko) 2003-10-08
JP2004520336A (ja) 2004-07-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A., E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.