BR0114618A - Método para facilitar a coalescência de dois membros selecionados do grupo que consiste de células, vesìculas, lipossomas e partìculas lipìdicas, lipossoma ou partìcula lipìdica, e, kit de reagentes - Google Patents

Método para facilitar a coalescência de dois membros selecionados do grupo que consiste de células, vesìculas, lipossomas e partìculas lipìdicas, lipossoma ou partìcula lipìdica, e, kit de reagentes

Info

Publication number
BR0114618A
BR0114618A BR0114618-1A BR0114618A BR0114618A BR 0114618 A BR0114618 A BR 0114618A BR 0114618 A BR0114618 A BR 0114618A BR 0114618 A BR0114618 A BR 0114618A
Authority
BR
Brazil
Prior art keywords
cells
liposomes
vesicles
liposome
lipid
Prior art date
Application number
BR0114618-1A
Other languages
English (en)
Other versions
BR0114618B1 (pt
Inventor
Sanjay Tyagi
Fred R Kramer
Osama A Alsmadi
Original Assignee
New York Health Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Health Res Inst filed Critical New York Health Res Inst
Publication of BR0114618A publication Critical patent/BR0114618A/pt
Publication of BR0114618B1 publication Critical patent/BR0114618B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"MéTODO PARA FACILITAR A COALESCêNCIA DE DOIS MEMBROS SELECIONADOS DO GRUPO QUE CONSISTE DE CéLULAS, VESìCULAS, LIPOSSOMAS E PARTìCULAS LIPìDICAS, LIPOSSOMA OU PARTìCULA LIPìDICA, E, KIT DE REAGENTES". Células, lipossomas e partículas de lipídeo são proporcionados com oligonucleotídeos de projeção complementar, que hibridizam para juntá-los como um auxiliar para fusão eficiente, que pode ser além disso auxiliada através de choque osmótico ou elétrico. A invenção além disso, proporciona pares complementares de oligonucleotídeos que contêm metades para ancorá-los em membranas celulares e lipossoma, bem como lipossomas que transportam agentes para serem introduzidos dentro de células e que são proporcionados com oligonucleotídeos de projeção ligados a membrana.
BRPI0114618-1A 2000-10-12 2001-10-11 Método para facilitar a coalescência de dois membros selecionados do grupo que consiste de células, vesículas de bicamada de lipídeo e lipossomas BR0114618B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23969800P 2000-10-12 2000-10-12
US60/239,698 2000-10-12
PCT/US2001/042658 WO2002033045A2 (en) 2000-10-12 2001-10-11 Oligonucleotide - facilitated coalescence

Publications (2)

Publication Number Publication Date
BR0114618A true BR0114618A (pt) 2005-12-13
BR0114618B1 BR0114618B1 (pt) 2014-06-10

Family

ID=22903339

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0114618-1A BR0114618B1 (pt) 2000-10-12 2001-10-11 Método para facilitar a coalescência de dois membros selecionados do grupo que consiste de células, vesículas de bicamada de lipídeo e lipossomas

Country Status (10)

Country Link
US (1) US7129087B2 (pt)
EP (1) EP1332220B1 (pt)
JP (1) JP4115833B2 (pt)
CN (1) CN1240842C (pt)
AT (1) ATE385257T1 (pt)
AU (2) AU2002232379B2 (pt)
BR (1) BR0114618B1 (pt)
CA (1) CA2425193C (pt)
DE (1) DE60132670T2 (pt)
WO (1) WO2002033045A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741577B2 (en) * 2003-04-07 2014-06-03 Bio-Rad Laboratories Inc. Surface immobilised multilayer structure of vesicles
NZ549643A (en) * 2004-02-26 2009-07-31 Layerlab Aktiebolag Methods of forming lipid membrane attached linkers comprising contacting membrane with an oligonucleotide having two or more hydrophobic anchoring moieties
WO2013067203A1 (en) * 2011-11-02 2013-05-10 The Regents Of The University Of California Reprogramming of cellular adhesion
EP3305721B1 (en) * 2015-06-08 2023-10-18 Japan Science And Technology Agency High-density micro-chamber array and measurement method using same
WO2017176894A1 (en) 2016-04-06 2017-10-12 Ohio State Innovation Foundation Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
GB9404709D0 (en) 1994-03-11 1994-04-27 Multilyte Ltd Binding assay
US5908635A (en) 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
US5756352A (en) * 1995-06-07 1998-05-26 Gen-Probe Incorporated Thiocationic lipid-nucleic acid conjugates
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
US5821354A (en) * 1996-11-26 1998-10-13 Angiogene Inc. Radiolabeled DNA oligonucleotide and method of preparation
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
GB9819417D0 (en) 1998-09-07 1998-10-28 Secr Defence Reaction method
ES2251134T3 (es) * 1999-06-08 2006-04-16 Gentium S.P.A. Uso de complejos entre liposomas cationicos y polidesoxirribonucleotidos como medicamentos.

Also Published As

Publication number Publication date
ATE385257T1 (de) 2008-02-15
AU2002232379B2 (en) 2006-07-13
CN1240842C (zh) 2006-02-08
CA2425193C (en) 2011-09-20
JP4115833B2 (ja) 2008-07-09
CA2425193A1 (en) 2002-04-25
DE60132670D1 (de) 2008-03-20
DE60132670T2 (de) 2009-02-05
WO2002033045A3 (en) 2002-10-10
EP1332220A4 (en) 2004-07-14
WO2002033045A2 (en) 2002-04-25
CN1505683A (zh) 2004-06-16
JP2004520816A (ja) 2004-07-15
AU3237902A (en) 2002-04-29
US7129087B2 (en) 2006-10-31
BR0114618B1 (pt) 2014-06-10
EP1332220B1 (en) 2008-01-30
US20040013654A1 (en) 2004-01-22
EP1332220A2 (en) 2003-08-06

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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/06/2014, OBSERVADAS AS CONDICOES LEGAIS.

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