BR0111473A - Métodos para triar um indivìduo quanto a uma doença de armazenagem de glicogênio, para triar um indivìduo quanto à doença de pompe, para monitorar a condição clìnica de um indivìduo com doença de pompe, para estimar a eficácia de um regime terapêutico em um indivìduo com doença de pompe e para determinar a concentração de um oligossacarìdeo em uma amostra biológica - Google Patents

Métodos para triar um indivìduo quanto a uma doença de armazenagem de glicogênio, para triar um indivìduo quanto à doença de pompe, para monitorar a condição clìnica de um indivìduo com doença de pompe, para estimar a eficácia de um regime terapêutico em um indivìduo com doença de pompe e para determinar a concentração de um oligossacarìdeo em uma amostra biológica

Info

Publication number
BR0111473A
BR0111473A BR0111473-5A BR0111473A BR0111473A BR 0111473 A BR0111473 A BR 0111473A BR 0111473 A BR0111473 A BR 0111473A BR 0111473 A BR0111473 A BR 0111473A
Authority
BR
Brazil
Prior art keywords
individual
disease
screening
methods
pomp
Prior art date
Application number
BR0111473-5A
Other languages
English (en)
Inventor
David S Millington
Yan An
Yuan Tsong Chen
Robert D Stevens
Sarah P Young
Johann L K Van Hove
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of BR0111473A publication Critical patent/BR0111473A/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"MéTODOS PARA TRIAR UM INDIVìDUO QUANTO A UMA DOENçA DE ARMAZENAGEM DE GLICOGêNIO, PARA TRIAR UM INDIVìDUO QUANTO à DOENçA DE POMPE, PARA MONITORAR A CONDIçãO CLìNICA DE UM INDIVìDUO COM DOENçA DE POMPE, PARA ESTIMAR A EFICáCIA DE UM REGIME TERAPêUTICO EM UM INDIVìDUO COM DOENçA DE POMPE E PARA DETERMINAR A CONCENTRAçãO DE UM OLIGOSSACARìDEO EM UMA AMOSTRA BIOLóGICA". São providos métodos de triar indivíduos quanto a doenças de armazenagem lisossomal, preferivelmente doenças de armazenagem de glicogênio, empregando-se um tetrassacarídeo como um biomarcador. Em uma versão mais preferida, os indivíduos são triados quanto à doença de Pompe (isto é, doença de armazenagem de glicogênio tipo II). São também providos ensaios de triagem neonatal. A presente invenção provê ainda métodos de monitoração da condição clínica e eficácia do tratamento terapêutico em indivíduos afetados. São ainda providos métodos de medir um biomarcador de tetrassacarídeo por espectrometria de massa seq³encial, preferivelmente como parte de um ensaio de triagem neonatal para a doença de Pompe.
BR0111473-5A 2000-06-07 2001-06-06 Métodos para triar um indivìduo quanto a uma doença de armazenagem de glicogênio, para triar um indivìduo quanto à doença de pompe, para monitorar a condição clìnica de um indivìduo com doença de pompe, para estimar a eficácia de um regime terapêutico em um indivìduo com doença de pompe e para determinar a concentração de um oligossacarìdeo em uma amostra biológica BR0111473A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20992000P 2000-06-07 2000-06-07
PCT/US2001/018288 WO2001094941A2 (en) 2000-06-07 2001-06-06 Diagnostic methods for pompe disease and other glycogen storage diseases

Publications (1)

Publication Number Publication Date
BR0111473A true BR0111473A (pt) 2004-01-13

Family

ID=22780875

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111473-5A BR0111473A (pt) 2000-06-07 2001-06-06 Métodos para triar um indivìduo quanto a uma doença de armazenagem de glicogênio, para triar um indivìduo quanto à doença de pompe, para monitorar a condição clìnica de um indivìduo com doença de pompe, para estimar a eficácia de um regime terapêutico em um indivìduo com doença de pompe e para determinar a concentração de um oligossacarìdeo em uma amostra biológica

Country Status (9)

Country Link
US (1) US20020102737A1 (pt)
EP (1) EP1360485A2 (pt)
JP (1) JP2004501365A (pt)
KR (1) KR20030021167A (pt)
AU (1) AU2001266733A1 (pt)
BR (1) BR0111473A (pt)
CA (1) CA2409989A1 (pt)
MX (1) MXPA02012032A (pt)
WO (1) WO2001094941A2 (pt)

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US7196323B2 (en) * 2002-02-28 2007-03-27 Metanomics Gmbh & Co. Kgaa Mass spectrometry method for analyzing mixtures of substances
AU2003220321A1 (en) * 2002-03-15 2003-09-29 University Of Utah Methods for quantitative analysis by tandem mass spectrometry
EP1497650A4 (en) * 2002-04-30 2008-04-02 Seikagaku Kogyo Co Ltd METHOD FOR DETECTING LYSOSOMAL STORAGE DISEASES
US6800489B2 (en) * 2002-06-05 2004-10-05 Izaak Walton Killam Health Center Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening
AUPS293002A0 (en) * 2002-06-14 2002-07-04 Women's And Children's Hospital Identification of oligosaccharides and their use in the diagnosis and evaluation of mucopolysaccharidoses and other related disorders
US20040096896A1 (en) * 2002-11-14 2004-05-20 Cedars-Sinai Medical Center Pattern recognition of serum proteins for the diagnosis or treatment of physiologic conditions
US7129049B2 (en) * 2003-12-22 2006-10-31 Regents Of The University Of Minnesota Method of detecting equine glycogen storage disease IV
ES2356343T3 (es) * 2005-05-20 2011-04-07 Germediq Forschungs- Und Entwicklungsgesellschaft Mbh Método para la determinación de factores de riesgo cardiovasculares en sangre desecada.
US8093062B2 (en) * 2007-03-22 2012-01-10 Theodore Winger Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil
US8202686B2 (en) * 2007-03-22 2012-06-19 Advanced Liquid Logic, Inc. Enzyme assays for a droplet actuator
US8440392B2 (en) * 2007-03-22 2013-05-14 Advanced Liquid Logic Inc. Method of conducting a droplet based enzymatic assay
US8497122B2 (en) * 2008-04-11 2013-07-30 Washington University Biomarkers for Niemann-pick C disease and related disorders
US8232073B2 (en) 2009-01-02 2012-07-31 Zacharon Pharmaceuticals, Inc. Quantification of non-reducing end glycan residual compounds
US9029530B2 (en) 2009-01-02 2015-05-12 Biomarin Pharmaceutical Inc. Detection of oligosaccharides
US8809009B2 (en) 2009-01-02 2014-08-19 Biomarin Pharmaceutical Inc. Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker
US8592140B2 (en) 2009-01-02 2013-11-26 Biomarin Pharmaceutical Inc. Detection of oligosaccharides
WO2010105112A1 (en) * 2009-03-11 2010-09-16 Hemaquest Pharmaceuticals, Inc. Detection of short-chain fatty acids in biological samples
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US9575064B2 (en) * 2014-09-02 2017-02-21 Perkinelmer Health Sciences, Inc. Methods relating to testing for lysosomal storage disorders
JP2021036232A (ja) 2019-08-23 2021-03-04 Ｊｃｒファーマ株式会社 脳脊髄液に含まれるＨｅｘ４，ｌｙｓｏ−ＧＭ１，Ｆｕｃ−ＧｌｃＮＡｃ−Ａｓｎ，及びｌｙｓｏ−ｓｕｌｆａｔｉｄｅの定量法
CN111610275A (zh) * 2020-06-08 2020-09-01 山东省分析测试中心 一种低聚麦芽糖的测定方法及在产品质量控制领域的应用

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Publication number Priority date Publication date Assignee Title
US5252489A (en) * 1989-01-17 1993-10-12 Macri James N Down syndrome screening method utilizing dried blood samples

Also Published As

Publication number Publication date
CA2409989A1 (en) 2001-12-13
JP2004501365A (ja) 2004-01-15
KR20030021167A (ko) 2003-03-12
EP1360485A2 (en) 2003-11-12
AU2001266733A1 (en) 2001-12-17
WO2001094941A3 (en) 2003-08-21
US20020102737A1 (en) 2002-08-01
MXPA02012032A (es) 2003-04-25
WO2001094941A2 (en) 2001-12-13

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired