BR0103797A - Derivados de fenoxifenilheterociclila como ssris - Google Patents
Derivados de fenoxifenilheterociclila como ssrisInfo
- Publication number
- BR0103797A BR0103797A BR0103797-8A BR0103797A BR0103797A BR 0103797 A BR0103797 A BR 0103797A BR 0103797 A BR0103797 A BR 0103797A BR 0103797 A BR0103797 A BR 0103797A
- Authority
- BR
- Brazil
- Prior art keywords
- heteroatoms
- c6alkyl
- nitrogen
- heterocyclic ring
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADOS DE FENOXIFENILHETEROCICLILA COMO SSRIs". A invenção proporciona compostos de fórmula geral ( I ) em que R^ 1^ 5 é H ou alquila C~ 1~-C~ 6~; R^ 2^ e R^ 3^, em conjunto com os átomos de interligação formam um anel saturado de 4 a 8 membros que contém um ou dois heteroátomos ( incluindo o nitrogênio ao qual R^ 2^ está ligado ) em que um segundo heteroátomo, se presente, é selecionado de entre oxigênio, nitrogênio e enxofre, com a condição de que o referido anel não pode conter dois heteroátomos adjacentes; Z é CF~ 3~, OCF~ 3~, alquiltio C~ 1~-C~ 6~ ou alcóxi C~ 1~-C~ 6~; Y é hidrogênio, halogêneo, -OR^ a^, R^ a^ ou alquiltio C~ 1~-C~ 6~ e em que R^ a^ é alquila C~ 1~-C~ 4~ facultativamente substituída com átomos de flúor; ou quando Z e Y estão ligados em para e meta em relação ao encadeamento de éter que liga os anéis A e B, Z e Y estão ligados de maneira que, em conjunto com os átomos de interligação, formam um anel carbocíclico ou heterocíclico de 5 a 7 membros condensado, o qual pode ser saturado, insaturado ou aromático, e em que quando Z e Y formam um anel heterocíclico, em adição a átomos de carbono, o encadeamento contém um ou dois heteroátomos independentemente selecionados de entre oxigênio, enxofre e nitrogênio; e Z e Y em conjunto não formam um anel fenilo condensado; R^ 4^ e R^ 5^, os quais podem ser iguais ou diferentes, são: A-X, em que A é igual a -CH=CH- ou -( CH~ 2~ )~ p~- onde p é 0, 1 ou 2; X é hidrogênio, F, CL, Br, L, CONR^ 6^R^ 7^, SO~ 2~NR^ 6^R^ 7^, SO~ 2~NHC(=O)R^ 6^, OH, alcóxi C~ 1~-C~ 4~, NR^ 8^SO~ 2~R^ 9^, NO~ 2~, NR^ 6^R^ 11^, CN, CO~ 2~R^ 10^, CHO, SR^ 10^, S(O)R^ 9^ ou SO~ 2~R^ 10^; ou um anel heterocíclico de 5 ou 6 membros contendo 1, 2 ou 3 heteroátomos selecionados de entre N, S e O facultativamente substituído independentemente por um ou mais R^ 13^; em que R^ 13^ é hidróxi, alcóxi C~ 1~-C~ 4~, F, alquila C~ 1~-C~ 6~, haloalquila, haloalcóxi, -NH~ 2~, -NH( alquila C~ 1~-C~ 6~ ) ou -N( alquila-C~ 1~-C~ 6~ )~ 2~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0021594A GB0021594D0 (en) | 2000-08-31 | 2000-08-31 | Diphenyl ether compounds useful in therapy |
| GB0105634A GB0105634D0 (en) | 2001-03-07 | 2001-03-07 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0103797A true BR0103797A (pt) | 2002-06-04 |
Family
ID=26244954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0103797-8A BR0103797A (pt) | 2000-08-31 | 2001-08-30 | Derivados de fenoxifenilheterociclila como ssris |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1184372B1 (pt) |
| JP (1) | JP3802782B2 (pt) |
| AT (1) | ATE324365T1 (pt) |
| BR (1) | BR0103797A (pt) |
| CA (1) | CA2356065C (pt) |
| DE (1) | DE60119047D1 (pt) |
| MX (1) | MXPA01008860A (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US7550485B2 (en) * | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| ES2340130B1 (es) * | 2008-11-27 | 2011-03-22 | Consejo Superior De Investigaciones Cientificas (Csic) | Funcionalizacion de 1-vinil-2 pirrolidona en posicion 3 mediante apertura de precursores ciclicos. |
| BR112013000602A2 (pt) * | 2010-07-09 | 2016-07-05 | Theravance Inc | forma cristalina de um composto 3-fenoximetilpirrolidina |
| BR112021024108A2 (pt) | 2019-05-31 | 2022-03-22 | Ikena Oncology Inc | Inibidores de tead e usos dos mesmos |
| MX2021014441A (es) | 2019-05-31 | 2022-01-06 | Ikena Oncology Inc | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. |
| US20240083903A1 (en) * | 2021-02-18 | 2024-03-14 | Merck Sharp & Dohme Llc | Aryl ether compounds as tead modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| GB2276162A (en) * | 1993-03-17 | 1994-09-21 | Glaxo Group Ltd | Aniline and benazilide derivatives |
| HUP0105488A3 (en) * | 1999-02-23 | 2005-07-28 | Pfizer Prod Inc | Monoamine reuptake inhibitors for treatment of cns disorders and pharmaceutical compositions containing the compounds |
-
2001
- 2001-08-17 DE DE60119047T patent/DE60119047D1/de not_active Expired - Lifetime
- 2001-08-17 AT AT01307032T patent/ATE324365T1/de not_active IP Right Cessation
- 2001-08-17 EP EP01307032A patent/EP1184372B1/en not_active Expired - Lifetime
- 2001-08-28 CA CA002356065A patent/CA2356065C/en not_active Expired - Fee Related
- 2001-08-29 JP JP2001259107A patent/JP3802782B2/ja not_active Expired - Fee Related
- 2001-08-30 MX MXPA01008860A patent/MXPA01008860A/es not_active Application Discontinuation
- 2001-08-30 BR BR0103797-8A patent/BR0103797A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002114762A (ja) | 2002-04-16 |
| CA2356065C (en) | 2005-04-12 |
| EP1184372A1 (en) | 2002-03-06 |
| DE60119047D1 (de) | 2006-06-01 |
| CA2356065A1 (en) | 2002-02-28 |
| MXPA01008860A (es) | 2002-08-20 |
| ATE324365T1 (de) | 2006-05-15 |
| JP3802782B2 (ja) | 2006-07-26 |
| EP1184372B1 (en) | 2006-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A , 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009. |