BR0011039A - Análogos de gaba substituìdos com 3-heteroarilalquila - Google Patents
Análogos de gaba substituìdos com 3-heteroarilalquilaInfo
- Publication number
- BR0011039A BR0011039A BR0011039-6A BR0011039A BR0011039A BR 0011039 A BR0011039 A BR 0011039A BR 0011039 A BR0011039 A BR 0011039A BR 0011039 A BR0011039 A BR 0011039A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- heteroarylalkyl
- disorders
- gaba analogs
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: "ANáLOGOS DE GABA SUBSTITUìDOS COM 3-HETEROARILALQUILA". Esta invenção é uma nova série de compostos que são úteis no tratamento de epilepsia, ataques de fraqueza, distúrbios neurodegenerativos, depressão, ansiedade, pânico, dor, distúrbios neuropatológicos, distúrbios gastrintestinais tal como síndrome da irritação intestinal (IBS), e inflamação, especialmente artrite. São incluídos uma composição farmacêutica que contém um composto da invenção, bem como métodos de preparação dos compostos e novos intermediários úteis na preparação dos produtos finais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13649199P | 1999-05-28 | 1999-05-28 | |
PCT/US2000/011397 WO2000073296A2 (en) | 1999-05-28 | 2000-04-28 | 3-heteroarylalkyl substituted gaba analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011039A true BR0011039A (pt) | 2002-02-26 |
Family
ID=22473084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011039-6A BR0011039A (pt) | 1999-05-28 | 2000-04-28 | Análogos de gaba substituìdos com 3-heteroarilalquila |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1185524B1 (pt) |
JP (1) | JP2003500486A (pt) |
AT (1) | ATE287880T1 (pt) |
AU (1) | AU4673200A (pt) |
BR (1) | BR0011039A (pt) |
CA (1) | CA2371089A1 (pt) |
DE (1) | DE60017730T2 (pt) |
ES (1) | ES2234599T3 (pt) |
MX (1) | MXPA01011059A (pt) |
PT (1) | PT1185524E (pt) |
TR (1) | TR200103399T2 (pt) |
WO (1) | WO2000073296A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
SG11201604480PA (en) | 2013-12-17 | 2016-07-28 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS |
EP3082790A1 (en) | 2013-12-17 | 2016-10-26 | Laboratorios Del. Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
CN115466234B (zh) * | 2022-10-25 | 2024-01-30 | 安徽华业香料股份有限公司 | 一种γ-庚内酯的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
CA2037123A1 (en) * | 1990-02-26 | 1991-08-27 | Jouveinal S.A. | Substituted ethylamines, their process of preparation, their use as medication and their synthetic intermediates |
FR2722192A1 (fr) * | 1994-07-06 | 1996-01-12 | Adir | Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JPH08119936A (ja) * | 1994-10-18 | 1996-05-14 | Fujisawa Pharmaceut Co Ltd | 複素環式誘導体 |
EP1015028A2 (en) * | 1997-09-19 | 2000-07-05 | Serex, Inc. | Methods to improve immunogenicity of antigens and specificity of antibodies |
-
2000
- 2000-04-28 WO PCT/US2000/011397 patent/WO2000073296A2/en active IP Right Grant
- 2000-04-28 ES ES00928498T patent/ES2234599T3/es not_active Expired - Lifetime
- 2000-04-28 BR BR0011039-6A patent/BR0011039A/pt not_active IP Right Cessation
- 2000-04-28 TR TR2001/03399T patent/TR200103399T2/xx unknown
- 2000-04-28 CA CA002371089A patent/CA2371089A1/en not_active Abandoned
- 2000-04-28 PT PT00928498T patent/PT1185524E/pt unknown
- 2000-04-28 JP JP2000621362A patent/JP2003500486A/ja active Pending
- 2000-04-28 AT AT00928498T patent/ATE287880T1/de not_active IP Right Cessation
- 2000-04-28 EP EP00928498A patent/EP1185524B1/en not_active Expired - Lifetime
- 2000-04-28 MX MXPA01011059A patent/MXPA01011059A/es active IP Right Grant
- 2000-04-28 DE DE60017730T patent/DE60017730T2/de not_active Expired - Fee Related
- 2000-04-28 AU AU46732/00A patent/AU4673200A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT1185524E (pt) | 2005-04-29 |
DE60017730D1 (de) | 2005-03-03 |
WO2000073296A2 (en) | 2000-12-07 |
MXPA01011059A (es) | 2002-06-04 |
JP2003500486A (ja) | 2003-01-07 |
WO2000073296A3 (en) | 2001-07-19 |
CA2371089A1 (en) | 2000-12-07 |
ES2234599T3 (es) | 2005-07-01 |
EP1185524B1 (en) | 2005-01-26 |
TR200103399T2 (tr) | 2002-04-22 |
AU4673200A (en) | 2000-12-18 |
ATE287880T1 (de) | 2005-02-15 |
DE60017730T2 (de) | 2005-06-23 |
EP1185524A2 (en) | 2002-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |