BR0010615A - Aril-cloro-etil-uréias inovadoras - Google Patents

Aril-cloro-etil-uréias inovadoras

Info

Publication number
BR0010615A
BR0010615A BR0010615-1A BR0010615A BR0010615A BR 0010615 A BR0010615 A BR 0010615A BR 0010615 A BR0010615 A BR 0010615A BR 0010615 A BR0010615 A BR 0010615A
Authority
BR
Brazil
Prior art keywords
alkyl
halide
derivatives
cycloalkyl
alkoxy
Prior art date
Application number
BR0010615-1A
Other languages
English (en)
Inventor
Rene C Gaudreault
Original Assignee
Univ Laval
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Laval filed Critical Univ Laval
Publication of BR0010615A publication Critical patent/BR0010615A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"ARIL-CLORO-ETIL-URéIAS INOVADORAS". Descreve-se na presente invenção derivados inovadores de 1aril-3-(2-cloro-etil)-uréias. Esses derivados são agentes anticancerígenos úteis, tendo excelente especificidade para células-alvo e potente atividade antineoplásica, sem toxicidade sistêmica ou mutagenicidade. Mais especificamente, a invenção refere-se a derivados inovadores da fórmula (I), onde R~ 1~, é alquila inferior de C~ 1~-C~ 6~, ciclo-alquila C~ 3~-C~ 7~, alcóxi inferior de C~ 1~-C~ 6~, hidróxi-alquila inferior de C~ 1~-C~ 6~, ou halogeneto inferior de C~ 1~-C~ 6~; R~ 2~ é H, alquila inferior de C~ 1~-C~ 6~, ciclo-alquila C~ 3~-C~ 7~, alcóxi inferior de C~ 1~-C~ 6~, hidróxialquila inferior de C~ 1~-C~ 6~, ou halogeneto, di-halogeneto ou tri-halogeneto inferiores de C~ 1~-C~ 6~, R~ 1~ e R~ 2~ poderiam ser também parte de estruturas cíclicas expressas pela fórmula (II); R~ 3~ e R~ 4~ são como definido em R~ 5~, ou halogeneto, di-halogeneto, tri-halogeneto, dialquila inferior de C~ 1~-C~ 7~, ou grupos alicíclicos com a estrutura (III), onde n = 2 a 8 átomos de carbono, sendo que o dito anel alicíclico pode ser também substituído com um ou mais grupos como definido em R~ 5~; ou anéis policíclicos que possuem não mais do que três anéis, onde os anéis, que não o anel que possui o grupamento 2-cloroetil-amino substituído, podem ser substituídos com um ou mais grupos como os definidos em R~ 5~; R~ 5~ é H, alquila inferior de C~ 1~-C~ 7~, alcóxi inferior de C~ 1~-C~ 7~, hidróxi-alquila de C~ 1~-C~ 7~, amino-alquila de C~ 1~-C~ 7~, tioalquila de C~ 1~-C~ 6~, S-alquila inferior de C~ 1~-C~ 5~, N-alquila inferior de C~ 1~-C~ 7~, N,N-dialquila inferior de C~ 1~-C~ 7~, ciano-alquila inferior de C~ 1~-C~ 9~, halo-alquila inferior de C~ 1~-C~ 7~, sulfóxido inferior de C~ 1~-C~ 7~, ou ciclo-alquila de C~ 3~-C~ 7~; ou um seu pró-medicamento. Descrevese também composições farmacêuticas que contêm os compostos da invenção em conjunto com um veículo de uso farmacêutico, e o uso das composições no tratamento de câncer.
BR0010615-1A 1999-04-12 2000-04-12 Aril-cloro-etil-uréias inovadoras BR0010615A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002268588A CA2268588A1 (en) 1999-04-12 1999-04-12 Novel aryl-chloro-ethyl ureas
PCT/CA2000/000413 WO2000061546A2 (en) 1999-04-12 2000-04-12 Novel aryl-chloro-ethyl ureas

Publications (1)

Publication Number Publication Date
BR0010615A true BR0010615A (pt) 2003-07-22

Family

ID=4163454

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010615-1A BR0010615A (pt) 1999-04-12 2000-04-12 Aril-cloro-etil-uréias inovadoras

Country Status (10)

Country Link
US (1) US6686394B1 (pt)
EP (1) EP1169303B1 (pt)
JP (1) JP2002541240A (pt)
AT (1) ATE312075T1 (pt)
AU (1) AU778391B2 (pt)
BR (1) BR0010615A (pt)
CA (1) CA2268588A1 (pt)
DE (1) DE60028563T2 (pt)
MX (1) MXPA01010311A (pt)
WO (1) WO2000061546A2 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61191667A (ja) 1985-02-21 1986-08-26 Tokuyama Soda Co Ltd 尿素化合物
CA2116621C (en) * 1993-03-03 2001-07-24 Rene C. Gaudreault Novel anticancer agents
US5750547A (en) 1995-01-06 1998-05-12 Universite Laval Certain carbanate anti-cancer agents

Also Published As

Publication number Publication date
JP2002541240A (ja) 2002-12-03
DE60028563D1 (de) 2006-07-20
CA2268588A1 (en) 2000-10-12
ATE312075T1 (de) 2005-12-15
DE60028563T2 (de) 2006-11-09
WO2000061546A3 (en) 2001-01-11
MXPA01010311A (es) 2005-09-08
AU3952000A (en) 2000-11-14
AU778391B2 (en) 2004-12-02
WO2000061546A2 (en) 2000-10-19
US6686394B1 (en) 2004-02-03
EP1169303B1 (en) 2005-12-07
EP1169303A2 (en) 2002-01-09

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SOVAR, SOCIETE EN COMMANDITE (CA)

Free format text: TRANSFERIDO DE: UNIVERSITE LAVAL

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.