BR0005525A - Inibidores de protease e seus usos farmacêuticos - Google Patents

Inibidores de protease e seus usos farmacêuticos

Info

Publication number
BR0005525A
BR0005525A BR0005525-5A BR0005525A BR0005525A BR 0005525 A BR0005525 A BR 0005525A BR 0005525 A BR0005525 A BR 0005525A BR 0005525 A BR0005525 A BR 0005525A
Authority
BR
Brazil
Prior art keywords
protease inhibitors
pharmaceutical uses
peptideomimetic
isosterate
dihydroxyethylene
Prior art date
Application number
BR0005525-5A
Other languages
English (en)
Inventor
Emerson Poley Pecanha
Luciana J O Figueiredo
Vera Bongertz
Octavio Augusto Ceva Antunes
Amilcar Tanuri
Rodrigo De Moraes Brindeiro
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Priority to BR0005525-5A priority Critical patent/BR0005525A/pt
Priority to OA1200200219A priority patent/OA12164A/en
Priority to PCT/BR2001/000141 priority patent/WO2002042412A2/en
Priority to EP01997538A priority patent/EP1335895A2/en
Priority to JP2002545118A priority patent/JP2004513971A/ja
Priority to CN01805607A priority patent/CN1406223A/zh
Priority to US10/181,817 priority patent/US20030158152A1/en
Priority to AU2002223313A priority patent/AU2002223313A1/en
Priority to APAP/P/2002/002584A priority patent/AP2002002584A0/en
Priority to ZA200205854A priority patent/ZA200205854B/en
Publication of BR0005525A publication Critical patent/BR0005525A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

"INIBIDORES DE PROTEASE E SEUS USOS FARMACêUTICOS". Onde: A presente invenção se refere a inibidores de protease sintéticos tendo um eixo de simetria C~ 2~ ou pseudo-C~ 2~ caracterizados por possuir, na porção central: (1) preferencialmente, uma função dihidroxietileno, isóstera a uma ligação peptídica; (2) uma ponte peptideomimética entre os dois nitrogênios e (3) radicais capazes de mimetizar aminoácidos. Esses novos inibidores de protease são a base para a preparação de formulações anti-virais capazes de cessar a proliferação de vírus HIV.
BR0005525-5A 2000-11-23 2000-11-23 Inibidores de protease e seus usos farmacêuticos BR0005525A (pt)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BR0005525-5A BR0005525A (pt) 2000-11-23 2000-11-23 Inibidores de protease e seus usos farmacêuticos
OA1200200219A OA12164A (en) 2000-11-23 2001-11-22 Protease inhibitors and their pharmaceutical uses.
PCT/BR2001/000141 WO2002042412A2 (en) 2000-11-23 2001-11-22 Protease inhibitors and their pharmaceutical uses
EP01997538A EP1335895A2 (en) 2000-11-23 2001-11-22 Protease inhibitors and their pharmaceutical uses
JP2002545118A JP2004513971A (ja) 2000-11-23 2001-11-22 プロテアーゼ・インヒビタ及びその医薬的使用方法
CN01805607A CN1406223A (zh) 2000-11-23 2001-11-22 蛋白酶抑制剂及其制药用途
US10/181,817 US20030158152A1 (en) 2000-11-23 2001-11-22 Protease inhibitors and their pharmaceutical uses
AU2002223313A AU2002223313A1 (en) 2000-11-23 2001-11-22 Protease inhibitors and their pharmaceutical uses
APAP/P/2002/002584A AP2002002584A0 (en) 2000-11-23 2001-11-22 Protease Inhibitors And Thier Pharmaceutical Uses.
ZA200205854A ZA200205854B (en) 2000-11-23 2002-07-22 Protease inhibitors and their pharmaceutical uses.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR0005525-5A BR0005525A (pt) 2000-11-23 2000-11-23 Inibidores de protease e seus usos farmacêuticos

Publications (1)

Publication Number Publication Date
BR0005525A true BR0005525A (pt) 2003-09-02

Family

ID=3945806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0005525-5A BR0005525A (pt) 2000-11-23 2000-11-23 Inibidores de protease e seus usos farmacêuticos

Country Status (10)

Country Link
US (1) US20030158152A1 (pt)
EP (1) EP1335895A2 (pt)
JP (1) JP2004513971A (pt)
CN (1) CN1406223A (pt)
AP (1) AP2002002584A0 (pt)
AU (1) AU2002223313A1 (pt)
BR (1) BR0005525A (pt)
OA (1) OA12164A (pt)
WO (1) WO2002042412A2 (pt)
ZA (1) ZA200205854B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091902A2 (en) * 2005-02-23 2006-08-31 E.I. Dupont De Nemours And Company Alpha, omega-difunctional aldaramides
US20060264672A1 (en) * 2005-02-23 2006-11-23 Andrews Mark A Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers
EP2459638B1 (en) 2009-07-31 2017-09-27 Rutgers, The State University of New Jersey Monomers and phase-separated biocompatible polymer compositions prepared therefrom for medical uses
EP3461855B1 (en) 2009-10-11 2020-05-27 Rutgers, The State University of New Jersey Biocompatible polymers for medical devices
EP3312155B1 (en) 2012-02-03 2020-08-05 Rutgers, The State University of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
CN104211666B (zh) * 2013-05-31 2017-11-14 中国人民解放军军事医学科学院毒物药物研究所 2,3‑环氧丁二酰胺类化合物、其制备方法和用途
AU2015370426B2 (en) 2014-12-23 2019-09-12 Rutgers, The State University Of New Jersey Biocompatible iodinated diphenol monomers and polymers
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
RU2017138549A (ru) * 2015-04-23 2019-05-23 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД Ингибиторы репликации вируса иммунодефицита человека

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855297A (en) * 1971-03-10 1974-12-17 Sterling Drug Inc 1,1{40 -bridged-bis{8 n-(alkyl)-2-aminoethanols{9

Also Published As

Publication number Publication date
EP1335895A2 (en) 2003-08-20
JP2004513971A (ja) 2004-05-13
AU2002223313A1 (en) 2002-06-03
OA12164A (en) 2006-05-08
WO2002042412A3 (en) 2002-10-31
AP2002002584A0 (en) 2002-09-30
US20030158152A1 (en) 2003-08-21
CN1406223A (zh) 2003-03-26
WO2002042412A2 (en) 2002-05-30
ZA200205854B (en) 2003-10-22

Similar Documents

Publication Publication Date Title
ATE444756T1 (de) Zusammensetzungen umfassend komplexe von tocopherolphosphatderivaten
BR0005525A (pt) Inibidores de protease e seus usos farmacêuticos
BRPI0409068A (pt) composições farmacêuticas para inibidores de protease viral de hepatite c.
BRPI0507652A (pt) composições farmacêuticas compreendendo um derivado de benzoidiazepina e um inibidor da proeìna de fusão de rsv
ES2721172T3 (es) Una nueva clase de moléculas terapéuticas a base de proteínas
BR9814956A (pt) Inibidores de benzotiazol da tirosina cinase de proteìna
PT1245568E (pt) Derivados sulfonilo de aminoacidos e sua utilizacao enquanto inibidores da dipeptidil-peptidase iv (dpp iv)
ECSP11005768A (es) Derivados de azol-pirimidina condensados
ATE330595T1 (de) Formulierung von aminosäuren und riboflavin zur verringerung der toxischen effekte der zytotoxischen chemotherapie
CY1105008T1 (el) Αντιμικροβιακη ενεργοτητα του πρωτου κατιονικου συγκροτηματος της ανθρωπινης λακτοφερρινης
CY1113312T1 (el) Κυκλικοι αναστολεις κινασης τυροσινης πρωτεϊνων
BR0211989A (pt) Compostos bicìclicos aromáticos substituìdos por aminoalquila, métodos para a sua preparação e seu uso como produtos farmacêuticos
BR0113666A (pt) Inibidores da protease peptidomimética
NO20010995D0 (no) Cytotoksiske peptider modifisert med store eller lipofile rester
BR9803880A (pt) Derivados de pirazol, sua preparação e seu emprego em medicamentos.
CY1109523T1 (el) Φαρμακευτικη συνθεση η οποια περιλαμβανει ενα παραγωγο βενζοδιαζεπινης και εναν αναστολεα της πρωτεϊνης συντηξης rsv
BR0211289A (pt) Derivados de dolastatina 10
BR0009678A (pt) Compostos, composição farmacêutica, e, uso de compostos
BR9801150A (pt) Derivados de propanolamina, processos para a preparação deles, produtos farmacêuticos compreendendo esses compostos e uso dos mesmos.
BR0007294A (pt) Formulações farmacêuticas aperfeiçoadas
BR0210531A (pt) Derivados de ácido sulfÈnico
BRPI0408299A (pt) inibidores de catepsina s
IT1276162B1 (it) Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
BR0111055A (pt) Formulação farmacêutica, e, processo para a preparação e uso da mesma
BR0202681A (pt) Compostos de octaidro-2h-pirido[1,2a]pirazina, um processo para sua preparação e composições farmacêuticas contendo-as

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (BR/RJ)

Free format text: TRANSFERIDO DE: FIOCRUZ - FUNDACAO OSWALDO CRUZ

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.