BG97845A - Medicamentous premix - Google Patents

Abstract

The medication premix is used in veterinary medicine for prophylaxis and treatment of gastrointestinal, pulmonary and blood nematodes; ectoparasites. It has high biological activity and noticed toxic and other side effects when used. The premix contains 0.2% by weight. Avermectins and macro-micronutrients, in particular lactose, starch, proteins and others. Additionally, it also contains synthetic naalsio2 in an amount of 5 to 15% wt. Against the active biomass.

Description

The invention relates to a medicament premix for the prevention and treatment of gastrointestinal, pulmonary and blood nematodes and ectoparasites: lice, fleas, scabies and pastures ticks, sucking flies, larval forms of insects and the like. The dosage form is suitable for both individual and group treatment of animals via food.

Methods for the prevention and treatment of nematodoses in mammals and birds with different mechanisms of action are known in the art - simple heterocyclic compounds (phenothiazine, piperazine), benzimidazole derivatives (thiabendazole, albendazole, cambendazole, fenbendazole, mebendazol, benzobenzazol, mebendazol febantel, thiophanate, netobimine, imidazothiazoles (levamisole, tetramisole, butamizole), tetrahydropyramidines (pyrantel, morantel), organophosphorus compounds (dichlorvos, haloxone, coumafos, metrifonate, anfomatol, etc.) ibiotitsi (ayvermektin, milbemycin, hygromycin), enzymes (papain), dietilkarbamozin, butyl chloride and the like.

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For combating ectoparasites (lice, fleas, mange and pasture ticks sucking flies, larval forms of insects, etc.) Is most often applied organophosphorus compounds - diazinon, fenthion, chlorpyrifos, coumaphos, krotoksifoshlorfenvinfos, dichlorvos, dimetoad, famphur, malathion et al., pyrethroids (aletrin, permethrin, deltamethrin, cypermethrin, flumetrin, fluvalenate, etc.), organochlorine derivatives (lindane, bromocycline, etc.), carbamate compounds (carbaryl) and others.

Avermectin preparations, which are active against both nematodes and ectoparasites, have been widely used in recent years.

The medicament premix according to the patent contains 0.2% Avermectins of complexes B and A, macro and micro nutrients: lactose, starch, proteins, etc., characterized in that it additionally contains sodium alumosilicate in an amount of 5 * 15% relative to the initial biologically active biomass.

Sodium aluminosilicate is obtained by neutralizing sodium silicate with aluminum sulfate. Its formula is as follows: NaAlSiO.

Sodium alumosilicate is an excellent free-flowing reagent determined by its maximum fineness. It forms a surface layer of powdered products or granules and acts as a dry lubricant so that the particles slip against each other and do not harden. They absorb condensed or separated fractions as soon as they occur and thus do not allow particle agglomeration.

The proposed premix has a granulometric composition that satisfies the requirements for preparations intended for use in animal feed.

The high degree of flowability allows for mixing with feed for both small ruminants and non-ruminants (up to 10 kg) and large (over 300 kg) ruminants and non-ruminants.

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Example 1

GRANULOMETRIC COMPOSITION OF 0.2% PREMIX AS AVERAGE

STATISTICAL RESULTS OF FIVE SEQUENTIAL BATS

Size of sieve openings, mm Particle size by class, mm / min - max / Sith fraction S,% Permeability % 1 2 3 4 1,25 1.25 and above 1.25 - 100.00 1.00 1.00 - 1.25 0.075 99,025 th most common 0.80 0.80 - 1.00 0.57 99.43 0.63 0.63 - 0.80 18,00 82,00 0.40 0.40 - 0.63 27,00 73.00 0.20 0.20 - 0.40 34,50 65,50 below 0.20 0.00 - 0.20 19,85 81,15 Example 2 Rheological indicators of: BULMECTIN 0.2% PREMIX

INDICATORS Values Bulk volume before crushing, cm ^ / g 2.2 Fr. Bulk volume after shaking, cm / d 1.8 Compact density before impact, g / cm ^ 0.45 3 Compact post-shake density, g / cm Pressability,% 0.74 18,8

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The drug premix is conveniently applied both to single animals and to the mass treatment of herds of goats, sheep, pig boxes and other animals.

'• and Example 3

ANTEMATODIC ACTIVITY OF BULMECTIN 0.2¾ PREMIX

1. Injected once a day with food at a dose of g / 10 kg m. The preparation Bulmectin 0,2¾ premix possesses SJ's extensive and intensifiable against the common gastrointestinal strands in sheep, goats and calves in the country, as well as against the parasitic nematodes in the respiratory tract. Dictyocaulus filaria.

Its effect (EE and IE 73%) on the respiratory protostrongilid species Cystocaulus, Protostrongylus Kochi, Protostrongylus drevispiculatum, Cystocaulus nigrescens and Muellerius capillaris is weaker.

2. Injected once via food in a dose

1.5 g / 10 kg m. The preparation Bulmectin 0.2¾ premix is highly effective against intestinal nematodes in pigs - extensibility against Ascarissuum, Trichocephalus suis n Oesophagustomum sp.

80-100¾ and intensity of 99.7-100¾ for A.suum, 98.94-100¾ for T.suis and 78-100¾ for Oesophagustomum spp.

3. After a single internal administration of the food at a dose of lg / 10kg m, the preparation Bulmectin 0,2¾ premix induces a cleansing of the horses, donkeys and cuticles of the intestinal Strongylates of the genera Strongilus, Cyatostomum, Cysticostum, Parascaris and others.

4. Injected once with the food at a dose of lg / 10kg m. The preparation Bulmectin 0.2¾ premix possesses SQT extens and efficacy in dogs infested with Toxascaris leonina, Toxacara canis, Ancylostoma caninum and Uncinaria stenocephala.

5. Injected once via food in a dose

0,1 and 0,2 g / kg m. The preparation Bulmectin 0,2¾ premix destroys over 92¾ of the larvae and imaginal forms of Ascaridia galli by the 48th hour.

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Example 4

ANTI-ARACHNOID ACTIVITY OF BULMECTIN 0.2% PREMIX

1. Injected once with food or with a bottle at a dose of 2g / 10kg m. The preparation Bulmectin 0.2% premix is highly effective against psoriasis scabies in sheep with extents and intensities above 95%. Higher and consistent treatment results are achieved with individual treatment of the sheep, 2 times every 12-14 days. Moreover, due to the long-acting effect of the preparation (for 14-21 days), it is not necessary to carry out acaricidal treatment of the environment with other acaricidal agents.

2. Once administered internally with food at doses of 1.3-1.5 g / 10kg m. The preparation Bulmectin 0.2% premix results in the cure of 100% of pigs with sarcoptic scabies.

3. Injected once or twice daily for 14 days with food at a dose of 0.1 g / kg m. The preparation of Bulemctin premix results in the cure of dogs by demodex scabies.

4. Injected once with food at a dose of 0, 1g / kg m. The preparation Bulmectin 0.2% premix has a high therapeutic efficacy for ear scabies in rabbits.

5. Injected once at a dose of 1 g / 10 kg m. The preparation Bulmectin premix 0,2% premix is highly effective and destroys 100% of the parasitic ticks of sheep Ornithodorus lahonsis in sheep.

Example 5

BULMECTIN INSECTICID ACTIVITY 0.2% PREMIX

1. Once administered internally with food at a dose of 2 g / 10 kg m. The preparation Bulmectin 0.2% premix leads to complete cure of sheep from estrogen by the 8th - 9th day after treatment.

2. Injected once at a dose of lg / 10 kg m. Bulmectin 0.2% premix eliminates 100% of the parasitic sheep in Melophagus ovinus sheep by the 5th day after treatment.

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3. Injected once at a dose of 1 g / 10kg i. The preparation Bulmectin 0.2% premix destroys over 90% of the larvae of Hypoderma independ in goats.

The method of treatment with Bulmectin 0.2% premix, characterized in that its administration occurs once or twice depending on the degree of infestation (morbidity), shows a certain nutritional effect in the absence of toxicity.

Example b

BULMECTIN TOXICITY INVESTIGATION 0.2% PREMIX

1. administered 6 times internally (with gastric tube) every 10 days at doses of 1 to 6 g / kg m. Bulmectin 0.2% premix does not adversely affect appetite, behavior, growth, clinicobiochemical composition of the blood and structure of the internal organs of white rats.

2. When administered to the diet of white rats for 30 days at a dose of 25 g / kg of feed, the preparation Bulmectin 0.2% premix does not adversely affect the behavior, growth, clinicobiochemical composition of the blood and the structural structure of the internal organs. From a dose of 50 g / kg of food, 40% of rats intoxicated and died by day 30.

3. When administered internally 9 times for 10 days at doses of 1 to 6 g / kg m. The preparation Bulmectin 0.2% premix does not adversely affect the fertilization, normal wear, lactation and development of the offspring in white rats.

4. Injected 2 times internally on days 5 and 13 from the onset of pregnancy at doses of 0.4 and 1 g / kg m. The preparation Bulmectin 0.2% premix has no embryotoxic and teratogenic effect in white rats.

5. In Ames mutagenic tests with Salmonela typhimurium TA

97a, TA 98, TA 100 and TA 102 Bulmectin at concentrations up to 3 mg / sample has no mutagenic activity. The same was confirmed in the micronucleus test with single-line C mice

BL internally with Bulmectin 0.2% at a dose of 1 g / kg m.

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5. Once administered internally at doses of 2 g / 10kg m in sheep and 1.5 g / kg m in pigs, the preparation Bulmectin 0.2% premix does not irritate the mucous membranes of the digestive canal and does not affect the normal function of the digestive system.

7. Once administered internally at doses of 2, 4 and 6 g / 10kg m (exceeding 2, 4 and 6 times the therapeutic doses) the preparation Bulmectin 0,2% premix is well tolerated and does not cause visible deviations in appetite, behavior and overall health. the condition of the sheep.

8. Intra-administered once mixed with food at 1.5, 4.5 and 7.5 g / 10kg m.

9. Once administered internally (after mixing with food) at doses of 0.1, 0.3 and 0.5 g / kg m. = 1, 3 and 5 times the therapeutic dose / preparation Bulmectin 0.2% premix is tolerated without manifestations. of toxicity from broiler chickens.

10. At single oral administration at doses of 0.1 0.3 and 0.5 g / kg m. = / 1, 3 and 5 times the therapeutic dose / preparation Bulmectin does not cause deviations from the normal health of dogs.

Claims (1)

Medicinal premix with 0.2% biological activity, containing natural avermectins obtained by deep cultivation of Streptomyces avermetillis strain No 1176/87 registered by NBMPCC, in the form of dried micelles containing 8 to 10% by weight of avermectins, as well as macro-avermectins micronutrients, in particular lactose, starch, proteins, etc., characterized in that the premix additionally contains precipitated synthetic sodium aluminosilicate in an amount of 5 wt.% by weight relative to the active biomass.