BG60662B1 - Medicamentous premix - Google Patents

Abstract

The medication premix is used in veterinary medicine for the prophylaxis and treatment of gastrointestinal, pulmonary and blood nematodes and ectoparasites. It has high biological activity and no toxic and other side effects are observed when using it. The premix contains 0.2% by weight. Avermectins and macro-micronutrients, in particular lactose, starch, proteins, and the like. Additionally, it also contains synthetic naphtha in an amount of 5 to 15% by weight. Against the active biomass.

Description

(54) MEDICAMENTOSE PREMIX

The invention relates to a medicated drug for the prevention and treatment of gastrointestinal, pulmonary and blood nematoses and ectoparasites: lice, fleas, scabies and pastures, blood sucking flies, larval forms of insects and the like. The dosage form is suitable for both individual and group treatment of animals through food.

Methods for the prevention and treatment of nematoses in mammals and birds with different mechanisms of action are known in the art - simple heterocyclic compounds (fsnothiazine, piperazine), benzimidazole derivatives (thiabendazole, albendazole, cambendazole, fenbendazole, mebendazol febantel, thiophanate, netobimine, imidazothiazoles (levamisole, tetramisole, butamizole), tetrahydropyramidines (pyrantel, morantel), organophosphorus compounds (dichlorvos, haloxone, coumafos, metrifonate, antifreeze, etc.) iotitsi (ayvermektin, milbemycin, hygromycin), enzymes (papain), dietilkarbamozin, butyl chloride and the like.

For combating ectoparasites (lice, fleas, mange and pasture ticks sucking flies, larval forms of insects, etc.) Is most often applied organophosphorus compounds - diazinon, fenthion, chlorpyrifos, coumaphos, krotoksifoshlorfenvinfos, dichlorvos, dimetoad, famphur, malathion et al., pyrethroids (aletrin, permethrin, deltamethrin, cypermethrin, flumetrin, fluvalenate, etc.), organochlorine derivatives (lindane, bromocycline, etc.), carbamate compounds (carbaryl) and others.

Ausrmectinitis preparations, which are active against both nematodes and ectoparasites, have been widely used in recent years.

The medicament premix form 5 according to the patent contains 0.2% Avermectins of complexes B and A, macro and micronutrients: lactose, starch, proteins, etc., characterized in that it additionally contains sodium alumosilicate 10 in an amount of 5-15% relative to the original biologically active biomass.

Sodium aluminosilicate is obtained by neutralizing sodium silicate with aluminum sulfate. Its formula is 15 NaAlSiO ₂ and is a milky white fine powder with a hardness of 3.5-5, a particle size of 20-40 μ, a density of 1.9-2.7, a loss on ignition of 8-11% and a loss on drying of 8% .

Sodium alumosilicate is an excellent 20 free-flowing reagent determined by its maximum fineness. It forms a surface layer of powdered products or granules and acts as a dry lubricant so that the particles slip against each other 25 and do not harden. They absorb condensed or separated fractions as soon as they occur and thus do not allow particle agglomeration.

The proposed premix has a granular 30 metric composition which satisfies the requirements for preparations intended for use in animal feed.

The high degree of flowability allows for mixing with feed for both small 35 ruminants and non-ruminants (up to 10 kg) and large (over 300 kg) ruminants and ruminants.

Example 1.

Granulometric composition of 0.2% premix as average statistical results from five consecutive batches

Size of sieve openings, mm Particle size by class, mm / min - max / Sieve fraction S,% Permeability, % 1,25 1.25 and above 1.25 100.00 1.00 1.00 1,25 0.075 99,025 th most common 0.80 0.80 1.00 0.57 99.43 0.63 0.63 0.80 18,00 82,00 0.40 0.40 0.63 27,00 73.00 0.20 0.20 0.40 34,50 65,50 below 0.20 0.00 0.20 19,85 81,15

Example 2.

Geological indices of Bulmectin 0.2% premix

Indicators Values Bulk volume before shaking, cm ³ / g 2.2 Bulk volume after shaking, cm ³ / g 1.8 Compact pre-shake density, g / cm ³ 0.45 Compact density after shaking, g / cm ³ 0.74 Pressability,% 18,8

The drug premix is conveniently applied both to single animals and to the mass treatment of herds of goats, sheep, pig boxes and other animals.

Example 3.

Bulmectin anti-hematopoietic activity 0.2% premix

1. Injected once with the food at a dose of 1 g / 10 kg m. The preparation Bulmectin 0.2% premix has 100% extensibility and intensification against the common gastrointestinal strangules in sheep, goats and calves, as well as against the respiratory parasitic nematode Dictyocaulus filaria. Its effect (EE and IE 73%) on the respiratory protostrongilid species Cystocaulus, Protostrongylus Kochi, Protostrongylus drevispiculatum, Cystocaulus nigrescens and Muellerius capillaris is weaker.

2. Injected once with the food at a dose of 1.5 g / 10 kg m. The preparation Bulmectin 0.2% premix is highly effective against intestinal nematodes in porcine ecstasy of Ascarissuum, Trichocephalus suis n Oesophagustomum sp. 80100% and intensification 99.7-100% for A.suum, 98.94-100% for T.suis and 78-100% for Oesophagustomum spp.

3. Following a single internal administration of food at a dose of 1 g / 10 kg m, the preparation Bulmectin 0.2% premix causes 100% ovine clearance of horses, donkeys and cuticles from the intestinal Strongylates of the genera Strongilus, Cyatostomum, Cylicastomum, Parascaris and others.

4. Injected once with the food at a dose of 1 g / 10 kg m

Bulmectin 0.2% premix has 100% extensibility and intensity in dogs infested with Toxascaris leonina, Toxacara canis, 20

Ancylostoma caninum and Uncinaria stenocephala.

5. Injected once with the food at a dose of 0.1 and 0.2 g / kg m. The preparation Bulmectin 0.2% premix destroys over 92% of the larvae and imaginal forms of Ascaridia galli by the 48th hour.

Example 4.

Bulmectin anti-arachnoid activity 0.2% premix

1. Injected once with food or with a bottle at a dose of 2 g / 10 kg m. The preparation Bulmectin 0.2% premix is highly effective against psoriasis scabies in sheep with extents and intensities above 95%. Higher and constant therapeutic results are achieved with individual treatment of the sheep, 2 times every 12-14 days. However, due to the prolonged action of the preparation (for 14-21 days), it is not necessary to carry out acaricidal treatment of the environment with other acaricidal agents.

2. Once administered internally with food at doses of 1.3-1.5 g / 10 kg m. The preparation Bulmectin 0.2% premix results in the cure of 100% of pigs with sarcoptic scabies.

3. Injected once or twice daily for 14 days with food at a dose of 0.1 g / kg m. The preparation Bulmectin premix leads to

5θ cure dogs for demodex scabies.

4. Injected once with the food at a dose of 0.1 g / kg m

Bulmectin 0.2% premix has high therapeutic efficacy for ear scabies in rabbits.

5. Injected once at a dose of I g / 10 kg m. The Bulmsctin Premix 0.2% premix preparation is highly effective and destroys 100% of the parasitic ticks of Ornithodorus lahonsis in sheep.

Example 5.

Bulmectin Insecticidal Activity 0.2% premix

1. Once administered internally with food at a dose of 2 g / 10 kg m. Bulmsctin 0.2% premix preparation leads to complete cure of sheep from estrogen by the 8-9th day after treatment.

2. Injected once at a dose of 1 g / 10 kg m. Bulmectin 0.2% premix eliminates 100% of the parasitic sheep in Melophagus ovinus sheep by the 5th day after treatment.

3. Injected once at a dose of 1 g / 10 kg m. The preparation Bulmectin 0.2% premix destroys over 90% of the larvae of Hypoderma independ in goats.

The Bulmectin 0.2% premix feeding method is characterized in that its administration is performed once or twice depending on the degree of infestation (morbidity), showing a certain nutritional effect in the absence of toxicity.

Example 6

Bulmectin toxicity study 0.2% premix

1. Injected 6 times internally (with gastric tube) every 10 days at doses from 1 to 6 g / kg m. Bulmectin 0.2% premix does not adversely affect the appetite, behavior, growth, clinical and biochemical composition of the blood and the structural structure of the internal organs of white rats.

2. When administered to the diet of white rats for 30 days at a dose of 25 g / kg of feed, the preparation Bulmectin 0.2% premix does not adversely affect the behavior, growth, clinical and biochemical composition of the blood and the structural structure of the internal organs. From a dose of 50 g / kg of food, 40% of rats intoxicated and died by day 30.

3. Applied internally 9 times in 10 days, in doses of 1 to 6 g / kg m.

Bulmectin 0.2% premix did not adversely affect the fertilization, normal wear, lactation and development of litters in white rats.

4. Injected 2 times internally on days 5 and 13 from the onset of pregnancy at doses of 0.4 and 1 g / kg m. The preparation Bulmectin 0.2% premix has no embryotoxic and teratogenic effect in white rats.

5. In mutagenic tests of Ames with Salmonela typhimurium Т A 97a, TA 98, TA 100 and TA 102 Bulmectin at concentrations up to 3 mg / sample did not show mutagenic activity. The same was confirmed in the micronucleus test, mice C _J7 BL treated once with Bulmectin 0.2% at a dose of 1 g / kg m.

6. Once administered internally at doses of 2 g / 10 kg m in sheep and 1.5 g / kg m in pigs, the preparation Bulmectin 0.2% premix does not irritate the mucous membranes of the digestive canal and does not affect the normal function of the digestive system.

7. Once administered internally at doses of 2, 4 and 6 g / 10 kg m (exceeding 2, 4 and 6 times the therapeutic doses) the preparation Bulmectin 0,2% premix is well tolerated and does not cause any visible deviations in appetite, behavior and general the health of the sheep.

8. Intra-administered once mixed with food at a dose of 1.5, 4.5 and 7.5 g / 10 kg m. = 1.3 and 5 times the therapeutic dose / preparation Bulmectin premix does not adversely affect pig health .

9. Once administered internally (after mixing the food) at doses of 0.1, 0.3 and 0.5 g / kg m. = 1, 3 and 5 times the therapeutic dose / preparation Bulmectin 0.2% premix is tolerated without manifestations. of chicken broiler toxicity.

10. In single oral doses of 0.1 0.3 and 0.5 g / kg m. = / 1, 3 and 5 times the therapeutic dose / preparation Bulmectin does not cause deviations from the normal health of dogs.

Claims (9)

Claims 1. A drug premix with 0.2% biological activity containing natural avermectins obtained by in-depth cultivation of Streptomyces avermetillis strain No. 1176/87, registered by NBMCC, in the form of a dried micellar mass containing 8-10% by weight. avermectins, as well as macro micronutrients, in particular lactose, starch, proteins, etc., characterized in that the premix additionally contains precipitated synthetic sodium aluminosilicate in an amount of from 5 to 15% by weight. relative to active biomass. Literature 1. US 4 310 519. 2. US 4 173 571. 3. US 4 429 042. 4. US 4 160 084. 5. US 4 328 335. 6. US 4 573 995. 7. Averinectine, New Family of Potent Anth3elmintic Agents, Efficacy of the B _{| a} 5 component, l.R. Egerton, D.A. Ostind, L.S. Blair, C.H. Earv. Antimicrobial Agents and Chemotherary Mor. 1979, p. 372-378, Vol. 15 No. 1 3. 8. Avermectine, New Potent Family 10 Anth3elmintic Agents, Isolation and Chromatographic Properties — Thomas W. Milier, Jokis Chait. Antimicrobial Agents and Chemotherapy, Mar. 1979, p. 637-371, Vol. 15, No. 1 3. 9. Campbell, William C., / Ivermectin and 15 Abamectin 1989 Springer - Verlay? - New York, Berlin, Heidelberg, London, Paris, Tokyo.