BG64037B1 - Means having complex biostimulating effect - Google Patents

Abstract

The means has complex biostimulating effect on the physical and mental condition of man, has increased anti-depressive effect, results in better expressed effects of restoration and maintenance of the normal functions of individual organs and systems. In addition, it has favourable effect on the sexual behaviour and on the function of the urogenital system. The means comprises dry extract of St. John's wort, standardized, based on hyperacine , and dry lactic acid product including wholesome or skimmed milk, fermented with selected strains Lactobacillus delbrueckii subsp. Bulgaricus, and containing vital lactic acid microorganisms over 1,000,000/l g product, pectin and from 1.5 to 3.5 wt. % complex of vitamins A, C, E, B1, B2, B12, niacin, calcium pantoneoate, folic acid, each in quantities within the boundaries of the pharmacological doses, optionally also mineral salts, and auxiliary substances such as calcium phosphate, aspartam, citric acid, dextrose, aromatizers. The means, in the form of soluble powder, can be offered in different dose packaging with instruction for the preparation, immediately before use, of products with the preferred consistency. The solid dosed form can be in the form of tablets, as toffees or in some other forms. 4 claims

Description

Technical field

The invention relates to the production of means for exerting a biostimulating effect on the physical and mental state of a person.

BACKGROUND OF THE INVENTION

Depression is one of the most common and of great medical and political importance. The most common forms of depression are from incarceration and suicide to destructive behavior dysphoria. One in five people has a depressive period in their lives. Statistically, 4% of the population is depressed at all times.

Therapeutic approaches to depression are theoretically determined by the concept of their neurotransmitter genesis, with the means available so far increasing the level of noradrenaline or serotonin in the synapse.

For the treatment of depressive states depressive disorder and mild to moderate depression, a number of agents are known, the so-called. antidepressants. The most widely used are synthetic antidepressants, such as Desipramin, Nomifensin, Clomipramin, Amitriptylin and the like. Heterocyclic antidepressants, which have many side effects, are especially effective. New generation antidepressants, selective serotonin reuptake inhibitors, are less effective but with less pronounced side effects. The aim is to create antidepressants that are highly effective in heterocyclic agents and are as free from unwanted side effects as possible.

Of interest in this respect is the new Esbericum preparation, which is a standard hypericinum dried St. John's wort (Hypericum perforatum) standard and contains hyperacins, flavonoids (quercetin and quercitrin), xanthones, bioflavonoids (bioapagenin and amentoflavinone). This remedy is highly effective, mild in action and has no unwanted side effects. It is most effective in patients with mild to moderate depression. Its good tolerability makes it suitable for patients with concomitant somatic diseases and in the elderly. It does not lead to addiction and long-term dependence.

The dosage form of Esbericum is a capsule form which contains, in addition to the dry extract of St. John's wort, lactose, magnesium stearate, highly dispersed silica, yellow iron oxide, gelatin, indigotine and titanium dioxide.

As is well known, depression manifests itself through a multitude of symptoms, such as resignation, despair, inner emptiness to the will to commit suicide. The condition of the body of patients after attempting to commit suicide by the administration of toxic substances requires that measures be taken to restore the normal functions of the individual organs and systems, in particular the gastrointestinal tract, liver, kidney, and cardiac function. These patients need, in addition to medicines and dietary nutrition, to aid recovery and maintain long-lasting function.

In addition, depressive states are often manifested by lack of appetite and an active attitude to a rational and complete diet, with atonic states, with a sense of fatigue and, consequently, low motor activity. Therefore, along with antidepressants, it is necessary to take biostimulating agents that affect the whole body.

Considering that patients outside the clinic and in the home setting, especially without special care by others, do not usually fulfill their appointments or do not perform them accurately and usually unwillingly take medications in their usual dosage forms, is a problem associated with the creation of such a form of antidepressant of natural origin, which can be readily accepted by patients, can also be taken as a nutritional supplement and to introduce into the body biostimulant substances that have a purpose o impact.

Various in form and content of biostimulating agents are known, including multivitamin complexes, plant extracts, protein hydrolysis, and the like. Also known is the stimulating effect of royal jelly containing essential amino acids, trace elements, vitamins, protein component and the like.

The biostimulating effect of low-lactose dry lactic acid dietary product (BG 52041) is known, mainly intended for the functional nutrition of severely ill and children and adults with lactase deficiency. The product contains low-lactose whole milk, low-lactose milk hydrolyzate with more than 95% degraded milk casein, low-lactose whole milk, fermented with selected strains of Lactobacillus bulgaricus, as well as sucrose, flavoring substances and pectin.

On the other hand, many diseases such as gastro-intestinal infections, ulcerative colitis, cardiovascular disease, toxic or viral hepatitis, some cancers, etc., occur with mild to moderately severe depressive conditions. However, the use of synthetic antidepressants and tranquilizers for the treatment of such conditions leads to additional damage to the body or is contraindicated in other diseases and often leads to addiction to the drug.

The treatment of these patients, as well as the restoration of the functions of different organs and systems and the maintenance of their functions in their normal parameters in patients with severe intoxication, is a serious problem, especially when combined with a depressive state, and the need to develop means with complex effects is obvious. on the body.

SUMMARY OF THE INVENTION

The problem of complex effects on the human body in need of antidepressant treatment or prophylaxis is solved according to the invention with an agent comprising a dry extract of St. John's wort standardized on hyperacin, a low-lactose lactic acid product containing skimmed low-lactose cow milk, fermented strains of Lactobacillus delbrueckii subsp. bulgaricus and containing viable lactic acid microorganisms over 1 000 000/1 g product, low lactose milk hydrolyzate with more than 95% degraded milk casein, sucrose, pectin, aspartame and a complex of vitamins selected from: vitamin A, vitamin C, vitamin E, vitamin B, vitamin1, , vitamin B2, vitamin B12, niacin, calcium pantoneoate, folic acid, each in a range of pharmacological doses, optionally mineral salts. The agent can be produced as a soluble powder in dosage forms, in solid dosage form, in tablet form for chewing, to give an attractive appearance, taste and aroma to achieve the intended purpose and to provide the combination agent in need.

The agent contains 0.02-0.08% by weight. St. John's wort dry extract and 1.5 to 3.5% multivitamin complex, by amount of lactic acid component.

The lactic acid component includes skimmed low-lactose cow's milk, fermented with selected strains of Lactobacillus delbrueckii subsp. bulgaricus and containing viable lactic acid microorganisms over 1 000 000/1 g of product from 70,0 to 74% by weight, low-lactose milk hydrolyzate with more than 95% degraded milk casein 9,0-10,0, sucrose 16,1-18,1 %, pectin about 1%, aspartame about 0.1% and flavoring agents.

The tablet formulation also contains excipients and excipients such as calcium phosphate, aspartame, citric acid, dextrose and essences.

The soluble powder may be available in a variety of dosage-appropriate packages, with instructions for preparation immediately before use of the product of preferred consistency.

The solid dosage form may be in the form of tablets, in the form of candy or other attractive design.

The agent of the invention has a general stimulating effect on the physical and mental state of the person. It has been found that the agent has a higher antidepressant effect than the extract of St. John's wort, leads to more pronounced effects of recovery and maintenance of normal functions of individual organs and systems, and has a beneficial effect on sexual behavior and functions of the 10 hunting system.

The remedy provides restoration of normal functions of individual organs and systems, in particular of the gastrointestinal tract, by suppressing the development of pathogens and conditionally pathogenic microorganisms, liver, kidney, cardiac activity, while compensating for the lack of vitamins in the body , the agent provides a faster and more effective therapeutic action. 20 The product is a completely natural product, with no side effects, it can be taken for a long time as a dietary supplement and as a food in a dosage amount.

The combination of the effects of pro-biotics with the antidepressant and stimulant effects of St. John's wort extract leads to a new level of disease treatment, using only natural products and eliminating the adverse side effects of medication.

Examples of carrying out the invention

OS

An example. Preparation of a product according to the invention.

From 890 1 (75,65 kg) skimmed milk cows prepare 800 1 low-lactose non-fat fresh milk and 90 1 sourced with selected strains of Lactobacillus delbrueckii subsp. bulgaricus and containing viable lactic acid micro-organisms exceeding 1 000 000/1 g product low-fat non-fat milk. To these were added 10.00 kg of milk low-lactose hydrolyzate, 18.00 kg of ⁴⁵ crystalline sugar, 1 kg of pectin, 0.1 kg of aspartame and 1.2 l of essence. The mixture was subjected to lyophilization. An estimated amount of 2.5% by weight was added to the dry product. Vitamin complex: Vitamin A, Vitamin C, Vitamin E, Vitamin B1, Vitamin B2, Vitamin

B12, niacin, calcium pantoneoate, folic acid, mineral salts and 0.04% dried St. John's wort extract.

For the preparation of 1 tablet of 3 g, 1.5 g of the described dry milk product is mixed with 0.08 g calcium phosphate, 0.1 g vitamin premix, aspartame 0.017 g, citric acid 0.004 g, flavoring agents 0.04 g, dextrose remaining to 3 g. The vitamin premix contains vitamin A 3000 IU, vitamin C - 75 mg, vitamin E - 10 mg, vitamin Bl - 2 mg, vitamin B2 - 2 mg, B6 - 2 mg, vitamin B12 - 5 gg, niacin - 20 mg, calcium pantotenoate - 10 mg and folic acid - 200 gg and 0.25 mg of dried St. John's wort extract.

100 g of dry lactic acid product which is 50% by weight. of the tablet means containing: fats from 16.0 to 20.0 g, protein substances from 23.0 to 27.0 g, total sugar, such as invert from 43.0 to 47.0 g, incl. lactose up to 4.0 g, water up to 6.0 g, pectin up to 1.0 g, minerals total up to 6.0 g, incl. calcium 1000 mg, potassium over 1500 mg, iron 0.8 mg, phosphorus 780 mg.

The product may also be presented in the form of 1.8 g tablets, in different grams of single dose, powder in one day packs and other suitable forms.

The drug was administered to 25 patients with allergic diseases, severe liver damage from phloid mushroom poisoning, viral hepatitis B and C viral drug addicts. Both liver function (judged by biochemical parameters) and sleep, general anxiety, anxiety and other symptoms characteristic of depressive conditions have been found to have a beneficial effect.

Claims (4)

What is claimed is: 1. A complex biostimulating agent comprising a dry extract of St. John's wort, a standardized hyperacin, low-lactose lactic acid product, comprising skimmed low-lactose cow's milk, fermented with selected strains of Lactobacillus delbrueckii subsp. bulgaricus and containing viable lactic acid microorganisms over 1 000 000/1 g product, low lactose milk hydrolyzate with more than 95% degraded milk casein, sucrose, pectin, aspartame, and a complex of vitamins selected from: vitamin A, vitamin C, vitamin E, vitamin E Vitamin B1, Vitamin B2, Vitamin B12, Niacin, Calcium Pantoneoate, Folic Acid, each in a range of pharmacological doses, optionally mineral salts. 10 An agent according to claim 1, characterized in that it contains 0.02θ, 08% by weight. St. John's wort dry extract and 1.5 to 3.5% multivitamin complex, based on the amount of lactic acid component. An agent according to claim 1, characterized in that the lactic acid product contains from 70.0 to 74% by weight. low-lactose cow's milk skimmed with selected strains of Lactobacillus delbrueckii subsp. bulgaricus, 9.0-10.0% by weight. low-lactose milk hydrolyzate with more than 95% degraded milk casein, from 16.1 to 18.1% by weight. sucrose, from 1.0 to 1.1% pectin, aspartame 0.1% wt. and flavoring substances. The agent according to claim 1, characterized in that it is in the form of soluble powder in finished dosage forms, in solid dosage form or in tablet form for chewing.