TWI692313B - Use of sports supplement composition - Google Patents

Abstract

The present invention provides a composition for exercise supplementation, which is used to improve the sports performance of athletes; the composition includes at least bitter melon seed oil and protein, and the weight ratio of bitter melon seed oil relative to the protein is 1: Between 1 and 10:1, wherein the bitter gourd seed oil contains more than 40% by weight of conjugated linolenic acid. The composition can promote the formation of type I muscle fibers and promote mitochondrial biosynthesis, increase muscle oxidized fatty acid production capacity, and thereby improve the user's physical function and exercise endurance. It can also be used in various functional health foods or beverages for users to take in a variety of different dosage forms, and because bitter gourd seed oil is taken from natural sources, it will not cause a burden on the human cardiovascular and liver, and can reduce the consumer's product Doubts about security.

Description

Use of sports supplement composition

The present invention relates to a composition for exercise supplementation, in particular to a composition for exercise supplementation containing bitter gourd seed oil and protein.

Athletes and sports enthusiasts often carry out a lot of sports training or participate in sports competitions. In the process of sports, a large amount of organic acids such as lactic acid and keto acid are produced in the muscles due to lack of oxygen, which makes the human body feel tired and exercise endurance decreases Hindered the performance of athletic performance; and in order to achieve outstanding athletic performance in a short period of time, some athletes even took anabolic steroids, erythropoietin (EPO), amphetamines and other dangerous and already prohibited sports supplements, resulting in serious Side effects or death.

Therefore, with the development of scientific research and the establishment of sports nutrition concepts, research and development of safe and compliant sports supplements or nutritional supplement ingredients for athletes or sports enthusiasts are increasingly accepted by sports workers and food developers. Pay attention and attention to delay fatigue, improve muscle strength, and improve high-intensity tolerance, thereby improving sports performance during training or competition, such as containing caffeine, branched chain amino acids (BCAA, Branched chain amino acids) , Or creatine (Creatine) and other ingredients that contribute to sports performance.

Caffeine is one of the most commonly used sports supplements by athletes; according to research, caffeine stimulates the central nervous system of the brain, makes athletes appear hyperactive, responds more quickly during exercise, and reduces athletes' long-term sports events Respond to fatigue; in addition, caffeine can also promote the release of fatty acids from the body and muscles into the blood for use, to save glycogen and increase the ability to store glycogen, which helps the endurance, especially for long-distance cycling and long-distance running Equal resistance Forceful exercise; In addition, some studies have pointed out that caffeine can affect the brain and spinal cord to neutralize the pain system, allowing athletes to reduce the pain and extend the exercise time.

Caffeine seems to be a safe and effective supplement, but it may also cause harmful side effects; for example, long-term or excessive consumption of caffeinated beverages may disrupt the rhythm of the heartbeat and cause arrhythmia; caffeine has a diuretic effect, Increase urine output, if endurance exercise is performed in hot weather, it is more likely to cause dehydration and electrolyte imbalance; in addition, when the habit of long-term intake of high amounts of caffeine, once stopped, easy to appear withdrawal symptoms, such as headache, anxiety, Irritability, insomnia and other side effects. Caffeine was once listed as one of the banned drugs by the International Olympic Committee. Although caffeine was excluded from the banned list in 2004, it was still included in the watch list by WADA.

Branched chain amino acids (BCAA, Branched chain amino acids) contains three essential amino acids such as Leucine, Isoleucine and Valine. Since the human body cannot synthesize it by itself, So it must be taken from the diet. According to research, branched chain amino acids can reduce muscle soreness, creatine kinase production and fatigue during exercise, and can maintain muscle mass and promote fat metabolism to save glycogen, so branched chain amino acids It is widely praised by bodybuilders, athletes, joggers and bikers as a nutritional supplement for sports and fitness training. However, taking too much branched-chain amino acids will increase the blood ammonia concentration, affect motor nerve control, or cause gastrointestinal discomfort. Long-term use is more likely to cause side effects of physical overdraft; in addition, when eating meat products, all amino groups The acid is ingested in an appropriate ratio, and excessive supplementation of branched-chain amino acids may interfere with the balance of amino acids in the body, and may cause long-term health effects.

Creatine is a natural compound that is ubiquitous in vertebrates and participates in the energy cycle that supplies muscle movement. It is composed of arginine, glycine, and methionine in the liver. , Synthesized in the kidney and pancreas, and then transported to the skeletal muscle through the circulation of blood, with creatine or phosphocreatine (PCr, phosphocreatine) Type storage, to provide the body needs, can also be supplemented through fish, meat, eggs and other animal products, so through a balanced diet can get the amount of creatine required by the general human body. However, the amount of creatine synthesized by the human body is limited. Under high-intensity and intense exercise, the general diet may still not be able to meet the needs; therefore, the creatine supplement can provide the body needs, additional creatine supplement, there are Helps to increase the storage of free creatine and creatine phosphate in the human body, increase the energy source of short-term high-intensity in the body, and thus improve the short-term sports performance. Although creatine is a highly safe sports supplement ingredient, creatine supplementation may affect the balance of electrolytes due to increased water content in the body, resulting in muscle spasm; in addition, additional supplementation of creatine will increase the permeability of cells, thus making The increase in cell volume leads to an increase in body weight, which may be a negative interference for certain sports, such as endurance sports. The increase in weight will cause athletes to bear greater body weight during training or competition. , And increase oxygen consumption; therefore, when taking creatine, you must consider the particularity of sports and creatine supplements caused by weight gain problems.

Therefore, although the above-mentioned sports supplements can improve the sports performance of athletes, they all have many unacceptable defects, such as lack of safety, impact on human health, unsuitability for long-term use, and limited to specific sports, etc. problem. Therefore, the industry is in urgent need of a new exercise supplement that can deeply research and develop a defect of the current technology, and can also take into account the safety of the human body without side effects.

Therefore, in view of this, the present inventors have diligently reviewed various possible solutions to the problems of the above-mentioned conventional technologies. After extensive analysis and experimental research, they further developed a composition containing bitter gourd seed oil and protein, which can promote the first Type I muscle fibers form and promote mitochondrial biosynthesis, increase muscle oxidized fatty acid production capacity, and thus improve the user's physical function and exercise endurance.

In other words, the present invention can provide a composition for exercise supplementation, which is used to improve the sports performance of athletes; the composition includes at least bitter gourd seed oil and protein, and the weight ratio of bitter gourd seed oil to the protein is Between 1:5 and 10:1; preferably between 1:5 and 8:1; more preferably between 1:5 and 5:1; most preferably between 1:2 and 2:1 between.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, wherein bitter gourd seed oil contains a specific ratio of conjugated linolenic acid (CLN); the conjugated linolenic acid (CLN) can be α-Teleoleic acid (α-eleostearic acid; α-ESA).

According to a specific embodiment of the present invention, a composition for exercise supplement can be provided, wherein the bitter gourd seed oil contains more than 40 wt% of α-eleostearic acid (α-ESA), preferably contains 53.0 wt %~71.4wt% α-tung oil acid

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, wherein the protein is myofibril protein, sarcoplasma protein, and stroma protein from meat; from milk Casein and whey protein; egg white protein and egg yolk protein from egg; albumin and globulin from soybean; gluten protein and alcohol from wheat It is composed of one or more of gliadins; preferably myofibril protein, sarcoplasma protein, and stroma protein from meat; casein from milk ( casein), and whey protein; one or more of egg white protein and egg yolk protein from eggs; more preferably myofibril protein and sarcoplasma protein from meat , And stroma protein; one or more of casein from whey protein and whey protein; the best is casein from milk and milk One or more of whey protein.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, which can promote muscle formation, preferably skeletal muscle formation.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, which can promote the formation of type I muscle fibers.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, which can promote mitochondrial biosynthesis.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, which can increase the expression levels of the Ppargc1a gene, Nrf1 gene, and Tfam gene.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, which further comprises at least one of additives, carriers, excipients, diluents, and combinations thereof, which can be performed according to different subjects Adjustment.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, wherein the excipient is composed of lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, It is composed of any one or more of tragacanth gum and combinations thereof.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided, wherein the dosage form of the composition is selected from a solution, an emulsion, a suspension, a powder, a lozenge, a pill, a lozenge, a tablet, a mouth Any of chewing gum and capsules.

According to a specific embodiment of the present invention, a composition for exercise supplementation can be provided. The composition can be in a dry form (such as a powder or a tablet) or an aqueous solution form (such as a beverage or a syrup), which can be a dietary supplement Agents or medicaments can also be beverages or foods, for example: tea (such as tea beverage or tea bag ingredients), soda, fruit juice (such as fruit extract or juice drink), milk, coffee, jelly, ice cream, yogurt, biscuits, Cereal, chocolate and snack bars. The composition for exercise supplement of the present invention can be used for exercise supplement in any of the aforementioned forms. The scope of the present invention also includes using the composition of the present invention as an active agent and using the composition to manufacture a medicament.

FIG. 1 is a graph showing a comparison of running time of each group of mice in the embodiment of the present invention.

FIG. 2 is a graph showing the comparison of running distance of each group of mice in the embodiment of the present invention.

FIG. 3 is a graph showing the comparison of the expression levels of Myh7 gene, Ppard gene, Nrf1 gene, and Tfam gene in each group of mice in the examples of the present invention.

In the following, different specific embodiments are listed and described in detail for the implementation of the present invention, so as to make the spirit and content of the present invention more complete and easy to understand; however, those with ordinary knowledge in this skill should understand The present invention is of course not limited to these examples, and other identical or equal functions and sequence of steps can be used to achieve the invention.

In this document, the meanings of the scientific and technical words used herein are the same as those understood and used by those with ordinary knowledge in the technical field to which the present invention belongs. In addition, without conflicting with the context, the singular noun used in this specification covers the plural form of the noun; and the plural noun used also covers the singular form of the noun.

In this article, the values and parameters used to define the scope of the present invention inevitably contain the standard deviation due to individual test methods, so most of them are expressed by approximate numerical values, but in specific embodiments Relevant values presented as accurately as possible. In this article, "about" generally depends on the consideration of those with ordinary knowledge in the technical field to which the present invention belongs, and generally means that the actual value falls within the acceptable standard error of the average value, for example, the actual value is Within ±10%, ±5%, ±1%, or ±0.5% of a specific value or range.

In this article, "beverage" and "food" broadly refer to all kinds of liquid and solid/semi-solid materials, each of which can provide animal nutrition and maintain normal or accelerate the growth of animals (including humans). Examples of beverage products include, but are not limited to, tea beverages, fruit juices, coffee and milk. Examples of food products include jelly, biscuits, cereals, chocolate, snack bars, herbal extracts, daily products (such as ice cream and yogurt), legume products (such as tofu), and rice products.

According to one embodiment of the present invention, the composition for exercise supplement of the present invention may be administered together with or without an excipient. In addition, the bitter melon seed oil-containing composition of the present invention may be formed into a solid dosage form containing various adjuvants, various disintegrants, granular binders or lubricants. In addition, in one embodiment, lactose or high molecular weight polyethylene glycol may also be used. In addition, as the case requires, it can be further used as a coating or coating layer for improving the release rate of any pharmaceutical active ingredient, such as an enteric coating. In other examples, the composition for exercise supplement of the present invention may also be formulated into a liposome structure or a bionic interstitial system structure, or may be filled in soft or hard gelatin capsules, or may be encapsulated Particles in a biodegradable medicine package.

Also, in the present invention, pharmaceutically acceptable excipients refer to those that are compatible with other ingredients in the pharmaceutical formulation and compatible with the organism, for example, encapsulating materials or such as absorption enhancers, antioxidants, adhesives , Buffers, coating agents, colorants, diluents, disintegrants, emulsifiers, supplements, fillers, flavoring agents, moisturizers, lubricants, fragrances, preservatives, propellants, release agents, fungicides, Various additives such as sweeteners, solubilizers, wetting agents and mixtures thereof. In addition, the additive may also be one of health nutrition ingredients, natural food ingredients, and combinations thereof. For example, the health nutrition ingredients may be citric acid, vitamins, amino acids, minerals, or other ingredients that are beneficial to human health ; And the natural food ingredient can be derived from ingredients such as vegetables, fruits or animals.

Adjuvants suitable for use in the present invention can be, for example, microcrystalline cellulose, calcium carbonate, dicalcium phosphate or glycine. Suitable disintegrants for use in the present invention are, for example, starch, alginic acid or specific silicates. The particulate binder suitable for use in the present invention can be, for example, polyvinylpyrrolidone, sucrose, gelatin, or acacia. Lubricants suitable for use in the present invention can be, for example, magnesium stearate, sodium lauryl sulfate, talc, or the like. Excipients suitable for use in the present invention, For example, for example, lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, and the like can be used.

In certain embodiments, the composition for exercise supplement of the present invention is formulated into a liquid dosage form suitable for oral administration, for example, oral suspension, emulsion, microemulsion, and/or elixirs. In the case of this liquid dosage form, the active ingredient of the antibody fat-forming preparation containing bitter gourd seed oil of the present invention can be further formulated with various sweeteners or flavors, colorants or dyes, and emulsifiers and And/or a suspending agent, or a diluent such as water, alcohol, propylene glycol, glycerin, or a buffer to maintain pH.

Furthermore, in some embodiments, alcohols, carboxymethyl cellulose dispersants, surfactants, emulsifiers, or other similar substances may be further added.

In addition, in some embodiments, the liquid formulation containing the bitter melon seed oil-containing composition of the present invention may be filled in a soft capsule and used.

In order to make the description of the disclosure more detailed and complete, the following provides an illustrative description of the embodiment and specific embodiments of the present invention; however, this is not the only form for implementing or using specific embodiments of the present invention. The embodiments cover the features of multiple specific embodiments, as well as the method steps and their sequence for constructing and operating these specific embodiments. However, other specific embodiments can also be used to achieve the same or equal functions and sequence of steps.

Hereinafter, the preferred embodiments of the present invention will be cited, and further detailed descriptions will be given in conjunction with the drawings as follows.

"Preparation of Bitter Gourd Seed Oil"

Place the bitter gourd seeds with a moisture content of less than 10% in the extraction tank under the conditions of pressure of 10MPa~60MPa, temperature of 20℃~60℃, flow rate of 30~60g/mL, and extraction time of 6-8 hours. Supercritical carbon dioxide fluid extracts crude extract of bitter gourd seed oil.

The bitter gourd seed oil extracted from the above supercritical carbon dioxide fluid was fed by GC/MS After analysis, it can be known that the content of α-tung oil acid in the bitter gourd seed oil is between 53.0 wt% and 71.4 wt%.

"Examples"

First, high-fat feeds F1, F2, F3, and F4 are prepared. Bitter gourd seed oil (BMSO) obtained from DL cystine (DL-Cystine), corn starch, corn sugar, sugar, protein, cellulose, cellulose, soybean oil, and the above preparation method , Butter (Butter), AIN-93 Vitamin mixture (AIN-93 Vitamin mixture), AIN-93 mineral mixture (AIN-93 Mineral mixture), and choline tartaric acid (Choline chloride) as shown in Table 1 by weight ratio High-fat feed F1, F2, F3 and F4 are prepared by mixing evenly; high-fat feed F1 contains 29.0wt% cream, 1.0wt% soybean oil, high-fat feed F2 contains 30wt% soybean oil, high-fat feed F3 contains 15wt% soybean oil, 15wt% bitter gourd seed oil, and high fat feed F4 contains 15wt% soybean oil and 15wt% bitter gourd seed oil. In addition, in this embodiment, the high-fat feed F1, F2, F3, and F4 all contain 26wt% protein, of which the high-fat feed F1, F2, F3 uses casein, and the high-fat feed F4 uses casein. Mixture with whey protein.

Then, 7-week-old male C57BL/6JNarl mice (purchased from the National Laboratory Animal Center) were selected, and after 2 weeks of adaptation, the mice were divided into sedentary groups (BT group, SB group, BM, BMP group) and exercise groups (BT/EX group, SB/EX group, BM/EX group, BMP/EX group) a total of 8 groups (n=6 for each group), and were fed high-fat diets F1, F2, F3, and F4, respectively. All mice were housed in an indoor environment of 23±2°C, and a 12-hour light-dark cycle was controlled, and feed and drinking water were freely available.

Table 1

During the feeding period, mice in the exercise group (BT/EX group, SB/EX group, BM/EX group, BPM/EX group) were subjected to running training (Columbus Instruments, Columbus, OH, USA) for 15 minutes per day, each 5 times a week (Monday to Friday). First start at a constant speed of 10m/min for 5 minutes, then adjust the inclination angle to 10° and accelerate to 20m/min with an acceleration of 1m/min. In addition, the mice in the sedentary group (BT group, SB group, BM group, BMP group) were also placed on the treadmill to adapt, but did not undergo training.

After continuous feeding for 3 weeks, sacrifice each group of mice by carbon dioxide euthanasia, and excise the muscles of the hind limbs of the mice to take out the gastrocnemius muscle for all biochemical and molecular analysis, because the gastrocnemius muscle has mixed muscles composed of type I muscle fibers and type II muscle fibers. Therefore, it may be affected by the fiber type. Aliquots of gastrocnemius muscle of each group of mice were quickly frozen in liquid nitrogen and stored at a temperature of -80°C for subsequent DNA, RNA and protein extraction

Next, the operation method of each detection index used in the embodiments of the present invention will be described below.

《RNA Isolation and mRNA Detection》

Using TRIzol reagent (purchased from Invitrogen, Carlsbad, CA, USA), total RNA was extracted from the gastrocnemius muscle tissue that had been homogenized, and after staining with ethidium bromide, the ratio of 28S/18S rRNA was calculated to confirm the quality of the total RNA. Next, 200 units of Moloney murine leukemia virus reverse transcriptase (MMLV-RT, purchased from Promega, Madison, WI, USA) were used to reverse transcribe 1 μg of total RNA as the first Strand cDNA (first-strand cDNA); when performing real-time PCR, use the SYBR system with self-designed primers (as shown in Table 2) and perform 40 cycles on the ABI Prism 7900HT sequence detection system (95 ℃ 15 seconds And 60°C for 1 minute).

"Statistical Analysis Methods"

In the examples herein, the data are expressed as mean ± SEM, and two-way analysis of variance (Two way ANOVA) was used to analyze the significance and interaction of dietary changes and exercise for different groups of mice . When there were significant differences (p<0.05), Bonferroni post-test or least squares method was used to analyze the differences between groups. If the variance is not homogeneous, the data is log-transformed before statistical analysis. All statistical analyses were performed using the General Linear Model package (SAS Institute, Cary, NC, USA).

In addition, the results of each test analysis will be described below.

"Sports Endurance Analysis"

All mice were evaluated for endurance the day before they were sacrificed. Place the mouse on a treadmill with an inclination of 10°, first start at a constant speed of 10m/min for 5 minutes, and then accelerate to 25m/min at an acceleration of 1m/min, and then maintain the speed at 25m/min until The mice are exhausted. In this embodiment, exhaustion is defined as a mouse that cannot be resumed running even after being gently stimulated, plus signs of physical exertion, such as difficulty breathing and open limbs. Then record the total running time of the mouse and calculate the total running distance of the mouse.

The average running time and average running distance of mice in each group are recorded in Table 3 and plotted as Figure 1 and Figure 2, respectively.

It can be seen from Table 3, Figures 1 and 2 above: in the group without seizure training (sedentary group), the running time and running distance of the mice in the BM and BMP groups are longer than those in the BT group and the SB group; Similarly, in the group with exercise training (sports group), the running time and running distance of the mice in the BM/EX group and the BMP/EX group were also higher than those in the BT/EX group and SB/EX group. long. It can be seen that whether exercise training is performed or not, it is shown that taking high-fat feed F3 and high-fat feed F4 containing both bitter gourd seed oil and protein can improve the exercise endurance of the users. Next, compare the group (B group, BMP group, BM/EX group, and BMP/EX group) of high fat feed F3 and high fat feed F4 containing bitter gourd seed oil and protein. BM/EX group The running time and running distance of the mice are longer than those of the BM group, and the running time and running distance of the mice of the BMP/EX group are also longer than those of the BMP group, indicating that in the case of exercise training, Taking high-fat feeds F3 and F4 containing bitter gourd seed oil and protein can significantly improve the exercise endurance of athletes or regular athletes and reduce fatigue during exercise; of which, BMP/EX group mice taking high-fat feed F4 run Both time and running distance are significantly better than other groups, showing that in the case of exercise training, the use of high-fat diet F4 can improve the performance of mice.

"Analysis of Muscle Fiber Type Conversion and Mitochondrial Function"

The gastrocnemius muscle of each group of mice was measured after RNA isolation and mRNA detection. Myh7 gene, Ppargc1a gene, Nrf1 gene, and Tfam gene expression levels, the average value of each group is recorded in Table 4 and plotted in Figure 3; where Myh7 gene is mainly expressed in type I muscle fibers, type I muscle fibers are rich Contains microvessels, myoglobin and mitochondria, can carry more oxygen, has high aerobic metabolism and anti-fatigue ability; Ppargc1a gene, Nrf1 gene, and Tfam gene lines are related to mitochondrial biogenesis .

Through the statistical analysis of the data in Table 4 and Figure 3 above, it can be seen that under the condition of exercise training, the mRNA expression levels of Myh7 gene, Ppargc1a gene, and Nrf1 gene in BM/EX group mice have been higher than that of BT/EX Group, and the SB/EX group, and the BMP/EX group of mice Myh7 gene, Ppargc1a gene, Nrf1 gene, and Tfam gene mRNA expression levels are significantly higher than other groups; in other words, in terms of muscle formation, it also contains Momordica charantia seed oil and protein high-fat feeds F3 and F4 can help mice with exercise training to generate type I muscle fibers, thereby improving aerobic metabolism and anti-fatigue ability; Seed oil and protein high-fat feeds F3 and F4 can also promote mitochondrial biosynthesis in mice with exercise training, thereby increasing muscle tolerance during exercise, and high-fat feed F4 is more effective.

Therefore, it can be confirmed that the composition for exercise supplementation of the present invention can help type I muscle fiber formation and promote mitochondrial biosynthesis, thereby increasing muscle oxidized fatty acid production capacity and It saves glycogen consumption, has excellent anti-fatigue ability and enhances sports endurance, so it helps to strengthen the sports performance of athletes or regular athletes. And because bitter gourd seed oil is taken from natural sources, it will not cause a burden on the human cardiovascular and liver, and can reduce the doubts of consumers about the safety of the product.

In summary, the content of the present invention has been exemplified and specifically described in the examples listed above, but the present invention is not limited to these embodiments. Those with ordinary knowledge in the technical field to which the present invention belongs should understand that various changes and modifications can be made without departing from the spirit and scope of the present invention; for example, combining the technical contents illustrated in the foregoing embodiments or Changed to a new embodiment, these embodiments are of course regarded as the content of the present invention. Therefore, the scope of protection in this case also includes the scope of patent application and the scope defined therein.

no.

Claims (9)

The use of a sports supplement composition is characterized by enhancing the endurance of athletes, wherein the composition at least comprises bitter gourd seed oil and protein, and the weight ratio of bitter gourd seed oil relative to the protein is 1:5 to 5:1 Between; wherein the bitter melon seed oil contains more than 40wt% of conjugated linolenic acid; the protein is composed of casein and whey protein, and the weight ratio of the casein relative to the whey protein is 21:5 . The use of the exercise supplement composition as described in claim 1 for promoting muscle formation. The use of the exercise supplement composition according to claim 1, which is used to promote the formation of type I muscle fibers. The use of the exercise supplement composition according to claim 1 is to promote mitochondrial biosynthesis. The use of the sports supplement composition as described in claim 1 is to increase the expression levels of the Ppargc1a gene, Nrf1 gene, and Tfam gene. The use of the sports supplement composition according to claim 1 as a food supplement or medicament. The use of the sports supplement composition according to claim 1, further comprising at least one of additives, carriers, excipients, diluents, and combinations thereof. The use of the sports supplement composition according to claim 7, wherein the excipient is selected from lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, and Any one or more than one of the combinations. Use of the sports supplement composition according to claim 7, wherein the dosage form of the composition is selected from the group consisting of solutions, emulsions, suspensions, powders, lozenges, pills, buccal tablets, tablets, chewable gums, and capsules Any of them.

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