BG60068B2 - Метод за получаване на диазинови производни - Google Patents

Метод за получаване на диазинови производни

Info

Publication number
BG60068B2
BG60068B2 BG094862A BG9486291A BG60068B2 BG 60068 B2 BG60068 B2 BG 60068B2 BG 094862 A BG094862 A BG 094862A BG 9486291 A BG9486291 A BG 9486291A BG 60068 B2 BG60068 B2 BG 60068B2
Authority
BG
Bulgaria
Prior art keywords
tetrazol
alkyl
preparation
diazine derivatives
phenyl
Prior art date
Application number
BG094862A
Other languages
English (en)
Inventor
David Roberts
Robert Pearce
Robert Bradbury
Richard William Luke
Original Assignee
Imperial Chemical Industries Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926211A external-priority patent/GB8926211D0/en
Priority claimed from GB909011348A external-priority patent/GB9011348D0/en
Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc
Publication of BG60068B2 publication Critical patent/BG60068B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Organic Insulating Materials (AREA)
  • Vibration Prevention Devices (AREA)

Abstract

Методът намира приложение в хуманната и ветеринарната медицина за получаване на лекарствени препарати против хипертония. Получените по метода диазинови производни са с обща формула в която пръстенът в означава пиридин, пиридазин, пиримидин или пиразин; х означава фенил, незадължително заместен с /с1-4/алкил, /с1-4/алкокси, халоген, трифлуорметил, цианоили нитро-, или х означава директна връзка между двете съседни групи фенилна или метиленова; z означава 1н-тетразол-5-ил, -со.nн./1н-тетразол-5-ил/ или група с формула -со.оr6 или -со.nн.о2.r7. 1 претенция
BG094862A 1989-11-20 1991-07-19 Метод за получаване на диазинови производни BG60068B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898926211A GB8926211D0 (en) 1989-11-20 1989-11-20 Diazine derivatives
GB909011348A GB9011348D0 (en) 1990-05-21 1990-05-21 Nitrogen heterocycles

Publications (1)

Publication Number Publication Date
BG60068B2 true BG60068B2 (bg) 1993-09-30

Family

ID=26296233

Family Applications (1)

Application Number Title Priority Date Filing Date
BG094862A BG60068B2 (bg) 1989-11-20 1991-07-19 Метод за получаване на диазинови производни

Country Status (17)

Country Link
US (1) US5126344A (bg)
EP (1) EP0454831B1 (bg)
JP (1) JPH04505161A (bg)
KR (1) KR920701206A (bg)
AT (1) ATE109481T1 (bg)
AU (1) AU6733690A (bg)
BG (1) BG60068B2 (bg)
CA (1) CA2030240A1 (bg)
DE (1) DE69011318T2 (bg)
FI (1) FI913478A0 (bg)
GB (1) GB9024730D0 (bg)
HU (1) HUT58334A (bg)
IE (1) IE903911A1 (bg)
IL (1) IL96407A0 (bg)
NZ (1) NZ236127A (bg)
PT (1) PT95929A (bg)
WO (1) WO1991007404A1 (bg)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000024I1 (de) * 1990-02-19 2010-07-08 Novartis Ag Acylverbindungen
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
GB9102804D0 (en) * 1991-02-11 1991-03-27 Ici Plc Heterocyclic derivatives
AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
JPH05213884A (ja) * 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
GB9113628D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic derivatives
GB9113626D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic compounds
US5246944A (en) * 1991-08-13 1993-09-21 Merck & Co., Inc. Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
GB9121727D0 (en) * 1991-10-14 1991-11-27 Ici Plc Heterocyclic compounds
GB9202633D0 (en) * 1992-02-07 1992-03-25 Fujisawa Pharmaceutical Co Heterocyclic derivatives
TW297025B (bg) * 1992-02-14 1997-02-01 Squibb & Sons Inc
WO1993017682A1 (en) * 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
GB2264710A (en) * 1992-03-04 1993-09-08 Merck & Co Inc Quinoline and azaquinoline angiotensin ii antagonists incorporating a substituted biphenyl element
GB9211270D0 (en) * 1992-05-28 1992-07-15 Ici Plc Nitrogen compounds
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EP1434773B1 (en) * 2001-10-04 2008-05-21 Merck & Co., Inc. Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5
AR037517A1 (es) * 2001-11-05 2004-11-17 Novartis Ag Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2017013237A1 (en) 2015-07-23 2017-01-26 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
EP3765613A1 (en) 2018-03-13 2021-01-20 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE3907937A1 (de) * 1989-03-11 1990-09-13 Basf Ag Substituierte 1,8-naphthylridine, verfahren zu ihrer herstellung und ihre verwendung als antidots
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives

Also Published As

Publication number Publication date
GB9024730D0 (en) 1991-01-02
DE69011318D1 (de) 1994-09-08
PT95929A (pt) 1991-09-13
EP0454831B1 (en) 1994-08-03
US5126344A (en) 1992-06-30
EP0454831A1 (en) 1991-11-06
ATE109481T1 (de) 1994-08-15
DE69011318T2 (de) 1994-12-01
HUT58334A (en) 1992-02-28
CA2030240A1 (en) 1991-05-21
KR920701206A (ko) 1992-08-11
FI913478A0 (fi) 1991-07-18
WO1991007404A1 (en) 1991-05-30
IL96407A0 (en) 1991-08-16
HU912485D0 (en) 1991-12-30
AU6733690A (en) 1991-06-13
IE903911A1 (en) 1991-05-22
NZ236127A (en) 1993-08-26
JPH04505161A (ja) 1992-09-10

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