BG1474U1 - Food additive increasing the protection of the epithelium of the lower urinary tract against recurring infections - Google Patents

Abstract

Food additive affecting the bacterial infection of the lower urinary tract, which as an effective ingredient contains mixture of max. 99.999975% lyophilized berries and/or juice from large cranberry (Vaccinium macrocarpon) and 0.00000025 to 0.0694% vitamin D in the form of ergocalciferol D2 or cholecalciferol D3 or mixtures thereof D2/D3. Its effect is to increase the surface resistance, i.e. of the epithelium, against the forming of colonies of uropathogenic bacteria.

Description

Technical field

The utility model concerns a nutritional supplement with effect - protection of the lower urinary tract against repeated bacterial infections, which contains a combination of lyophilized 10 fruits and / or fruit juices of big cranberries (Vaccinium macrocarpon) and vitamins Dj / Dj (ergocalciferol / cholecalciferol) . Its impact is expressed in the increase of surface resistance, ie. of the epithelium of the urinary tract against colonization of uropathogenic bacteria.

BACKGROUND OF THE INVENTION

Vaccinium macrocarpon (cranberry) and / or their juice have been used for centuries by North American indigenous populations to treat infectious diseases of the lower urinary tract in both sexes. The pharmacological effect of the substances contained in blueberries is based on the inhibition of bacterial adhesion of uropathogenic bacteria on the urinary epithelium. Thanks to the anti-adhesive effect 3 0, this culture has become a sought-after functional food or nutritional supplement in Europe. The substances contained in cranberry also have a great anti-inflammatory and antioxidant effect, inhibiting the pathogenesis of pathogenic bacteria in the gastric and urinary tract epithelium (Howell AB (2007)). urinary tract infections Mol Nutr Food Res. 51, 732-737; 40 Howell AB et al. (2010) Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double BMC 45 Infectious Diseases 10, 94; Shmuely H, Yahav J, Samra Z et al. (2007) Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics a a nd a proton pump inhibitor Mol. Nutr. Food Res. 51,746-751; YamanakaA, Kimizuka 50

R, Kato T, Okuda K. (2004) Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol. Immunol. 19, 150-154; Jepson RG, Craig JC (2008) Cranberries for the prevention of urinary tract infections. Cochrane Database Systemic Reviews, issue 4, CD 001321).

Vitamin D is a key signaling molecule (hormone) in regulating the metabolism (homeostasis) of calcium in the body, mineralization of bone tissue, affecting its density and remodeling. The physiological level of 25-hydroxyvitamin D in childhood is essential for bone growth, in adults for bone quality and in the elderly for delaying osteoporosis and reducing the risk of bone fractures. Low blood 25-hydroxyvitamin D levels are associated with an increased risk of colon cancer, the onset of autoimmune diseases, type 1 diabetes, and cardiovascular disease. In a clinical study, the addition of vitamin D increased the antibacterial protection of the epithelium of the lower urinary tract and bladder by inducing the gene responsible for cathelicidin synthesis. This peptide prevents colonization of urgopathogenic bacteria in the urinary tract (Cavalier E et al. (2009) Vitamin D: current status and perspectives. Clin Chem Lab Med 47 (2), 120-127; Rosen CJ (2011) Vitamin D insufficiency. N J Med 364,248-254; Souberbielle JC et al. (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmunity Reviews 9, 709715; Hertting O (2010) Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLOS one 5 (12), el 5580).

The purpose of the utility model is to enrich the market with a nutritional supplement - a product containing as an active ingredient a combination of whole lyophilized large blueberry fruits or their juices and dried juices or extracts and vitamin D ₂ / D ₃ (ergocalciferol / cholecalciferol). The purpose of this combination is to exploit the synergism of the anti-adhesive effects of cranberry and the regulatory function of vitamin D on the synthesis of the antimicrobial peptide cathelicidin in the epithelium of

1474 Ul urinary tract, thereby preventing bacterial infections of the urinary tract and colonization of nauropathogenic bacteria. Both ingredients have no side effects. There are products on the market that contain cranberry juice in combination with vitamins A, B, C, D and E, and are available in the form of juices, fruit jellies or chewing gums, as described, for example, in documents: RU 2242145, CN 101590093, EA 200801042 or US 7056541. The active ingredient content of Vaccinium macrocarpon and vitamin D in these products corresponds to the food category but not to the food additive. The declared content of vitamin D in the proposed composition of the nutritional supplement, in addition to the declared effect, supplements the deficiency of this vitamin in the average European population. Acute hypercalcemia, which can be achieved with daily doses of vitamin D above 10,000 IU, i. over 150 ng of 25-hydroxyvitamin D in 1 ml of blood cannot be induced by the use of the suggested nutritional supplement.

The technical nature of the utility model

The stated objective is achieved by a technical solution, such as a nutritional supplement with effect on bacterial infection of the lower urinary tract, the essence of which is that as an active ingredient it contains a mixture of a maximum of 99.999975% of whole lyophilized large blueberry fruits and / or their juices and / or dried juices and / or extracts thereof and 0.00000025 to 0.0694% of vitamin D in the form of ergocalciferol D2 or cholecalciferol D3 or mixtures thereof D2 / D3.

In an advantageous embodiment, the active ingredient is mixed with up to 1000 times the physiologically harmless agent, optionally supplemented with excipients, when the harmless agent is composed of at least one of the substances selected from the group of softener or solvent or carrier, or consists of different variants of mixtures thereof as well as, where appropriate, the additional excipients are composed of at least one of the substances selected from the group of colloidal agents or antioxidants, or pigments, or stabilizers or emulsifiers, or lomo-forming agents, or when composed of different variants of the mixture.

In the optimal case, the softener is selected from the group of glycerol or polyol, the solvent consists of water or ethanol, and the carrier is selected from the group of gelatin or modified starch or cellulose and its derivatives, or starch and its derivatives, or calcium salts and sodium carbonate , calcium phosphate and carrageenan, or vegetable oils, or glycerin or triglycerides, or phosphate or invert syrup, or consisting of mixtures thereof. Also suitable, when the colloidal agent is selected from the group of silica and magnesium stearate or a mixture thereof, the antioxidant is selected from the group of tocopherols or rosemary acid, or sodium ascorbate, or ascorbyl palmitate, and when the colorants are selected from the group of colorants Iron oxide or titanium dioxide or natural vegetable concentrates are made up of different combinations of their mixtures. Finally, it is appropriate when the stabilizer is composed of beeswax or polysorbates or fatty acid polyglycerol esters, when the emulsifiers are selected from the group of lecithin or sorbitan monostereate or sorbitan monooleate or sorbitan tristereate or sorbitan monolaurate or sorbitan monolaurate monopalmitate, as well as when the film-forming agents are selected from the group of hydroxypropylmethylcellulose or hydroxypropylcellulose or polyethylene glycols or polyvinyl alcohol or shellac.

The dietary supplement contains polyphenols, i.e. anthocyanins, flavonoids, phenolic acids, minerals, and vitamins of the blueberry, which have beneficial physiological effects on the lower urinary tract and which, in combination with the effect of ergocalciferol D2 or cholecalciferol3, guarantee a reduction in the risk of infection with pathogens.

Examples of implementing the utility model

The specific possible application of the utility model is illustrated by the following examples of the use of nutritional supplements.

Example 1.

Nutritional supplement enhancing the 1474 Ul Ultra Shield of the epithelium of the lower urinary tract against repeated infections in the form of solid

capsules filled with liquid weighing 530 mg are with composition: - Active ingredients: 5 powder freeze dried fruit blueberry 180 mg ergocalciferol D2 0,005 mg - harmless carrier medium in the form of a mixture 10 gelatin 105 mg vegetable oil 225.615 mg a softener in the form of a multivalent alcohol 12.35 mg solvent in the form 15 of water 5.03 mg - Excipients: Antioxidant in the form of sodium ascorbate 2 mg Example 2. 20 Nutritional supplement that increases the the epithelium of the lower urinary tract mid- I will re-infect the formulation of soft powder capsules with a weight of 735 mg, is composed of: 25 - active ingredients: dried cranberry spray 200 mg cholecalciferol D3 0,005 mg - harmless means - 30 carrier in the form of a mixture of gelatin 142,545 mg soybean oil 290 mg glycerin softener 67.58 mg 35 solvent in the form of water 8.22 mg - auxiliary ingredients: antioxidant in the form of tocopherol acetate 2 mg 40 iron oxide coloring agent 1,65 mg beeswax stabilizer 10 mg emulsifier in the form 45 nalecithin 13 mg Example 3. Nutritional supplement that increases the the epithelium of the lower urinary tract mid-

re infections, administered in the form of 50 ka of hard powder capsules with powder weight

670 mg, is composed of:

- Active ingredients:

lyophilized blueberry powder 500 mg mixture of ergocalciferol D2 and cholecalciferol D3

- a harmless carrier medium in the form of a gelatin softener in the form of a glycerine solvent in the form of water

0.0075 mg

148.7925 mg

7.60 mg

3.60 mg

- Excipients: Antioxidants in the form of sodium ascorbate 2 mg agent in the form of colloidal silicon dioxide 8 mg

Example 4.

A nutritional supplement enhancing the protection of the epithelium of the lower urinary tract against repeated infections, administered in the form of tablets weighing 550 mg, has the following composition:

- Active ingredients:

dry extract of big red boron · mg ergocalciferol D2 0.005 mg

- harmless carrier in the form of a mixture of microcrystalline cellulose dicalcium phosphate carboxymethylcellulose cottonseed oil

- auxiliary ingredients:

230,045 mg

192.50 mg

13.75 mg

1.50 mg agent in the form of a colloidal mixture of magnesium stearate 3.30 mg of silica 4.80 mg of film-forming substances in the form of a mixture of hydroxypropyl methylcellulose

4.20 mg hydroxypropyl cellulose 3.40 mg dyes in the form of a mixture of titanium dioxide 2.50 mg natural vegetable concentrates 4 mg

Example 5.

A dietary supplement that enhances the protection of the epithelium of the lower urinary tract between 1474 ul and recurrent infections, administered in the form of a syrup of 5,000 mg, is composed of:

- Active ingredients: dried cranberry juice 500,0 mg ergocalciferol D2 - harmless form carrier 0.005 mg of invert syrup solvent in the form 4 492 995 mg of ethanol 5 mg - Excipients: Antioxidant in the form of sodium ascorbate 2 mg

Industrial applicability

The urinary epithelium-protective nutritional supplement may be used to prevent recurrent acute inflammation of the lower urinary tract caused by uropathogenic bacteria. The nutritional supplement also has a beneficial effect on the microbial flora of the digestive tract and supplements the vitamin D deficiency in today's population.

Claims (13)

Claims A nutritional supplement affecting bacterial infection of the lower urinary tract, characterized in that it contains a mixture of max. 99.999975% of whole lyophilized fruits of blueberry and / or its juice, as well as dried juice and / or extracts and 0.00000025 to 0.0694% of vitamin D in the form of ergocalciferol D2 or cholecalciferol D3 or mixtures D2 / D3. Food supplement according to claim 1, characterized in that the active ingredient is mixed with up to 1000 times a physiologically harmless agent, optionally supplemented with excipients. Food supplement according to claim 2, characterized in that the harmless agent consists of at least one of the substances selected from the group of softener or solvent or carrier, or consists of various variants of their mixtures. Food supplement according to claim 2, characterized in that the optional additives are composed of at least one of the substances selected from the group of colloidal agents or antioxidants or colorants or stabilizers or emulsifiers or film-forming substances or is made up of different variants of their mixtures. Food supplement according to claim 3, characterized in that the softener is selected from the group of glycerol or polyols. Food supplement according to claim 3, characterized in that the solvent is water or ethanol. Food supplement according to claim 3, characterized in that the carrier is selected from the group of gelatin or modified starch or cellulose and its derivatives or starch and its derivatives, or calcium salt and sodium carbonate or calcium phosphate and carrageenan salt, or vegetable oils, or glycerol and triglycerides, or glycerol, or phosphates, or invert syrup, and mixtures thereof. Food supplement according to claim 4, characterized in that the colloidal agent is selected from the group consisting of silicon dioxide and magnesium stearate, or is made up of mixtures thereof. Food supplement according to claim 4, characterized in that the antioxidant is selected from the group of tocopherols and rosemary acid or sodium ascorbate or ascorbyl palmitate. Food additive according to claim 4, characterized in that the coloring agents are selected from the group of iron oxide or titanium dioxide, or natural vegetable concentrates, or are made up of different combinations of mixtures thereof. Food additive according to claim 4, characterized in that the stabilizer is beeswax or polysorbates or esters of polyglycerol with fatty acids. 12. A dietary supplement according to claim 4, wherein the emulsifiers are selected from the group of lecithins or sorbitan monostereate or sorbitan monooleate or sorbitan monostereate or sorbitan monolaurate or sorbitan monopalmitate. 13. Food additive according to claim 4, characterized in that the film-forming agents are selected from the group of hydroxypropylmethylcellulose or hydroxypropylcellulose or polyethylene glycol or polyvinyl alcohol or shellac.