BG1055U1 - Cosmetic product - Google Patents

Abstract

The utility model relates to a cosmetic product having a purposive bioactive effect and containing herb-based active substances. It enriches the range of the cosmetic means with a purposive bioactiveeffect, in particular anti-inflammatory and tonic effect on the hypodermic tissue and the muscles as well as antiseptic, tonic and regenerating effect on the skin, using a herb-based active substancewith a minimum risk of any allergy causing effect. The product contains an active substance - aqueous extract of Summer Snowflake (Leucojum aestivum), a mixture of alkaloids, sometimes resin and wax, and it may or may not contain minimum quantities of galantamine, but no more than 0.5 percent.

Description

Technical field

The utility model relates to the field of cosmetics having a purposeful bioactive action and containing herbal-based active substances.

BACKGROUND OF THE INVENTION

A well-known ointment for joint and muscle pain and neuralgic pain, under the trade name Revulzofit, containing concretion of ayvadzhiva (red root) (Rad Alkannae tinktoriae) and essential oils of lavender, rosemary, eucalyptus, pine, juniper, basil, and basil , Sesame oil. In addition to cosmetic skin regenerating and nourishing effects, the ointment has anti-inflammatory and analgesic effects on joint, muscle and neuralgic pains (Veridia 21).

Massage oil is known, which relieves muscle and joint pain, especially in the case of fatigue, containing grape seed oil, wheat germ, essential oils of rosemary, juniper, lavender and salvia (Nada Essential Body Series).

An external dosage form (BG 62637) is known, which includes as active substance galanthamine or a pharmaceutically acceptable salt thereof in the form of a solution in a suitable hydrogel-type ointment base. The plaster form is applied for refreshing, toning and nourishing of the skin, for pain relief and treatment of plexitis, radiculitis, neuritis and more.

The technical nature of the utility model

The problem that is solved with the present utility model is the enrichment of the spectrum of cosmetics with targeted bioactive action, in particular anti-inflammatory and tonic effect on subcutaneous tissues and muscles, antiseptic, tonic and regenerating effect on the skin, using an active substance herbal base with minimal risk of allergic action. At the same time, the effect of simplifying the composition of the agent and hence the technology of preparation is sought. It also seeks to ensure continued fitness.

Problems are solved with a cosmetic product containing one active substance - an aqueous extract of marshmallow (Leucojum aestivum) containing a mixture of alkaloids, optionally resins and waxes, and not containing or containing at least 0.5% galanthamine . The alkaloid mixture includes alkaloids such as lycorin, homolicorin, 9-desmethylhomolicorin, as well as nivalidine, tacetin, lycorenin and the like. The cosmetic agent may be a gel (hydrogel, film-forming gel, contact gel), cream, massage emulsion or massage oil, lotion and containing galantamine, not more than 0.25%.

There are numerous descriptions and reports in the literature of various extracts from whole plants, bulbs and in vitro cultures of Leucojum aestivum, methods for their preparation and their widespread use in medicine. Most reports relate to high galanthamine extracts that have been investigated and used in the form of an extract or in pure form as a therapeutic agent and in the composition of various nutritional supplements and in the composition of a topical agent. Leucojum aestivum extracts were also tested, with 14 galantamine, lycorin, tacetin and crinan alkaloids found, and four groups showed antimalarial activity, the highest in lycorin type. The antinociceptin effect of ethanol extracts from Leucojum aestivum bulbs was also investigated. The use of aqueous extracts of Leucojum aestivum in cosmetic or topical preparations is unknown. Berkov S., Pavlov A., Ilieva M., Burrus M., Popov S., Stanilova M. “CGC-MS of alkaloids in Leucojum aestivum plants and their in vitro cultures” Phytochem Anal.2005 Mar-Apr; 16 (2): 98-103; Sener B., Orhan I., Satayavivad J. “Antimalarial activity screening of some alkaloids and plant extracts fromAmaryllidaceae” Phytother Res. 2003 Dec; 17 (10): 1220-3; Cakici I., Ulug HY, Inci S., Tunctan B., Abacioglu N., Kanzik I., Sener B., “Antinociceptive effect of some amaryllidaceae plants in mice” J Pharm Pharmcol. 1997 Aug; 49 (8): 828-30]

Hee found to be an aqueous extract of the Leucojum aestivum plant containing no or 2

1055 W galanthamine holding not more than 0.5% has a topical effect on the skin, subcutaneous tissue and muscles, causing skin regeneration and toning, toning and increasing muscle endurance. It has also been found to relieve pain in muscle cramps and stretching, in sports and chronic injuries, in severe physical activity on the limbs. Relieves unpleasant sensations of stiffness and back pain, frozen shoulder, neuralgia, sciatica, lumbago. The effect of pain relief is also due to the therapeutic effect on possible inflammatory processes manifested by pain in the damaged tissues.

The proposed cosmetic agent provides a very low risk of apergisation due to the content of only one active substance. In addition, there is a long-term preservation of the impact.

The utility model has an unexpected beneficial effect with the ability to utilize plant species not used in the preparation of galantamine extracts due to its low galantamine content.

Exemplary embodiments of the utility model

EXAMPLE 1. Gel formulation containing an aqueous extract of Leucojum aestivum

Distilled water up to 105 kg

The composition contains galantamine 0.1%

EXAMPLE 3 Gel formulation containing an aqueous extract of Leucojum aestivum

Composition per 100 kg, in kg:

Aqueous extract of

Leucojum aestivum50

Carbopol 9401

Propylene glycol7

Glycerin8

Ethyl alcohol 96% -en5

Triethanolamine 1,2

Nipagin0.05

Distilled water up to 100 kg

The composition contains galantamine 0.1%

Composition per 100 Kg, in Kg:

Aqueous extract of

Leucojum aestivum20

Carbopol 9401

Propylene glycol7

Glycerin8

Ethyl alcohol 96% -en5

Triethanolamine 1,2

Nipagin0.05

Distilled water up to 100 kg

The composition contains galantamine 0.016%

EXAMPLE 2. Cream

Composition for 105 kg, in kg

Aqueous extract of

Leucojum aestivum 20,170

Propylene glycol 10,000

Arlacel 12,750

Magnesium sulfate 0,200

EDTA 0.100

EXAMPLE 4. Cream

Composition for 105 kg, in kg

Aqueous extract of

Leucojum aestivum 50,170

Propylene glycol 10,000

Arlacel 12,750

Magnesium sulfate 0,200

EDTA 0.100

Distilled water up to 105 kg

The composition contains galantamine 0.25%.

The cosmetic product is applied by applying it locally to the site of pain or to the appropriate muscle, or to the surface of the skin that needs toning and regeneration - for example, wrinkles on the face or around the eyes.

Claims (4)

Claims 1. A cosmetic agent with a tonic, anti-inflammatory and regenerative effect on the skin, subcutaneous tissues and muscles, characterized in that it contains an active substance aqueous extract of marshmallow (Leucojum aestivum) containing a mixture of alkaloids which does not include galanthamine or containing in an amount not exceeding 0,5% and, if appropriate, containing resins and / or waxes and auxiliaries. Cosmetic agent according to claim 1, characterized in that the alkapoid mixture comprises alkaloids such as lycorin, homolicorin, 9-desmethylhomolicorin, nivalidine, tacetin, lycorenin. A cosmetic according to claim 1, characterized in that it is in the form of a gel, cream, emulsion, massage oil, lotion. A cosmetic according to claims 1 and 3, characterized in that it contains galantamine not more than 0.25%.