BG105581A - Тиоуреа съдържаща хетероцикличен карбоксамид с фенилендиаминогрупа като инхибитор на херпес вирус - Google Patents

Тиоуреа съдържаща хетероцикличен карбоксамид с фенилендиаминогрупа като инхибитор на херпес вирус

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Publication number
BG105581A
BG105581A BG105581A BG10558101A BG105581A BG 105581 A BG105581 A BG 105581A BG 105581 A BG105581 A BG 105581A BG 10558101 A BG10558101 A BG 10558101A BG 105581 A BG105581 A BG 105581A
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BG
Bulgaria
Prior art keywords
carbon atoms
alkyl
hydrogen
heteroaryl
herpes viruses
Prior art date
Application number
BG105581A
Other languages
English (en)
Inventor
Jonathan BLOOM
Kevin CURRAN
Martin DIGRANDI
Russell DUSHIN
Thomas Jones
Stanley Lang
Adma ROSS
Eugene Terefenko
Bryan O'HARA
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Wyeth filed Critical Wyeth
Publication of BG105581A publication Critical patent/BG105581A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Съединенията са полезни за лечение на заболявания, свързани с херпесен вирус, вкл. човешки цитомегаловирус, херпес симплекс вирус, Epstein-Barr вирус, варицела зостер вирус, човешки херпесен вирус-6 и -7 и херпесен вирус на Kaposi. Съединенията иматформула@@в която R1-R5 са избрани независимо от групата водород, алкил с 1 до 6 въглеродни атома, алкенил с 2 до 6 въглеродни атома, алкинил с 2 до 6въглеродни атома, перхалогеналкил с 1 до 6 въглеродни атома, циклоалкил с 3 до 10 въглеродни атома, 3- до 10-атомен хетероциклоалкил, арил, хетероарил, халоген, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) или W-Y-(CH2)n-Z, при условие, че поне един от R1-R5 не е водород; или R2 и R3, или R3 и R4 заедно образуват 3- до 7-атомен хетероциклоалкил или 3- до 7-атомен хетероарил; R6 и R7 са независими и означават водород, алкил с 1 до 6 въглеродни атома, перхалогеналкил с 1 до 6 въглеродни атома или арил; R8 еводород, алкил с 1 до 6 въглеродни атома, перхалогеналкил с 1 до 6 въглеродни атома, циклоалкил с 3до 10 въглеродни атома, 3- до 10-атомен хетероциклоалкил, арил, хетероарил или R7 и R8 заедно образуват 3- до 7-атомен хетероциклоалкил; W е О, NR6 или отсъства; Y е -(СО)- или -(СО2)- или отсъства; Z е алкил с 1 до 4 въглеродни атома, -СN, -CO2R6, -COR6, -CONR7R8, -OCOR6, NR6COR7, -OCONR6 -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) или фенил;G е моноциклен хетероарил; Х е връзка, -NH, алкилс 1 до 6 въглеродни атома, алкенил с 2 до 6 въглеродни атома, алко
BG105581A 1998-12-09 2001-06-08 Тиоуреа съдържаща хетероцикличен карбоксамид с фенилендиаминогрупа като инхибитор на херпес вирус BG105581A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20855998A 1998-12-09 1998-12-09
PCT/US1999/028842 WO2000034258A2 (en) 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group

Publications (1)

Publication Number Publication Date
BG105581A true BG105581A (bg) 2001-12-31

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ID=22775044

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105581A BG105581A (bg) 1998-12-09 2001-06-08 Тиоуреа съдържаща хетероцикличен карбоксамид с фенилендиаминогрупа като инхибитор на херпес вирус

Country Status (18)

Country Link
EP (1) EP1144397A3 (bg)
JP (1) JP2002531554A (bg)
CN (1) CN1348446A (bg)
AU (1) AU1934700A (bg)
BG (1) BG105581A (bg)
BR (1) BR9916046A (bg)
CA (1) CA2350767A1 (bg)
CZ (1) CZ20011956A3 (bg)
EA (1) EA200100631A1 (bg)
HU (1) HUP0200232A2 (bg)
ID (1) ID30158A (bg)
IL (1) IL143182A0 (bg)
NO (1) NO20012832L (bg)
PL (1) PL349217A1 (bg)
SK (1) SK7682001A3 (bg)
TR (1) TR200101664T2 (bg)
WO (1) WO2000034258A2 (bg)
ZA (1) ZA200104377B (bg)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064643A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
US8524907B2 (en) 2006-11-02 2013-09-03 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor
EP2914591B1 (en) * 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
WO2014070979A1 (en) * 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN110565100B (zh) * 2019-07-12 2021-05-07 西北工业大学 一种二茂钴阳离子基缓蚀剂及制备方法和使用方法
CN117769548A (zh) 2021-08-05 2024-03-26 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途
EP4433479A1 (en) 2021-11-19 2024-09-25 Basf Se Bicyclic compounds for the control of invertebrate pests
CN115433093A (zh) * 2022-09-26 2022-12-06 无锡双启科技有限公司 一种3-氯-4-三氟甲基苯胺的制备方法
CN115710190A (zh) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-甲氧基-2-氨基-n,n-二甲基苯胺、制备方法及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69830751T2 (de) * 1997-04-10 2006-05-18 Pharmacia & Upjohn Co. Llc, Kalamazoo Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen

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Publication number Publication date
WO2000034258A3 (en) 2001-11-29
PL349217A1 (en) 2002-07-01
NO20012832L (no) 2001-08-07
EP1144397A2 (en) 2001-10-17
CZ20011956A3 (cs) 2001-10-17
SK7682001A3 (en) 2002-07-02
IL143182A0 (en) 2002-04-21
BR9916046A (pt) 2001-10-02
JP2002531554A (ja) 2002-09-24
NO20012832D0 (no) 2001-06-08
AU1934700A (en) 2000-06-26
EP1144397A3 (en) 2002-09-11
CA2350767A1 (en) 2000-06-15
WO2000034258A2 (en) 2000-06-15
CN1348446A (zh) 2002-05-08
TR200101664T2 (tr) 2002-03-21
ID30158A (id) 2001-11-08
ZA200104377B (en) 2002-12-20
EA200100631A1 (ru) 2002-02-28
HUP0200232A2 (hu) 2002-05-29

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