BG103150A - Биароматни съединения и фармацевтични и козметични състави, които ги съдържат - Google Patents

Биароматни съединения и фармацевтични и козметични състави, които ги съдържат

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Publication number
BG103150A
BG103150A BG103150A BG10315099A BG103150A BG 103150 A BG103150 A BG 103150A BG 103150 A BG103150 A BG 103150A BG 10315099 A BG10315099 A BG 10315099A BG 103150 A BG103150 A BG 103150A
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alkyl
aryl
radical
compositios
cosmetic
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BG103150A
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BG63501B1 (bg
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Jean-Michel Bernardon
Simon Trouille
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Galderma Research & Development
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Publication of BG103150A publication Critical patent/BG103150A/bg
Publication of BG63501B1 publication Critical patent/BG63501B1/bg

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/35Ketones, e.g. benzophenone
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

Биароматните съединения имат формула, в която Ar означава групи с формули Z означава 0 или S; R1 е СН3, -СН2-0-R6, -OR6, -COR7, R2 е -OR8, -SR8или полиетерен радикал, ако в последния случай R4 е С1-С20 алкил и е в орто- или метаположение спрямо Х-Аr; R3 е алкил илиR2 и R3 заедно образуват цикъл, прекъснат по желание с 0 или S; R4 е Н, халоген, С1-С20 алкил, -OR8, полиетерен или арилен радикал; R5 е Н, халоген, С1-С20 алкил или -OR8; R6 е Н, алкил или -СОR9; R7означава Н, алкил, -N/r'//r''/ или -OR10; R8 е Н,алкил или -COR9; R9 е алкил; R10 е Н, С1-С20 алкил, алкенил, монохидроксиалкил или полихидроксиалкил, арил или аралкил или захарен остатък; r' и r'' са Н, алкил, моно- или полихидроксиалкил, арил, остатък от захар или аминокиселина или заедно образуват хетероцикъл; Х е радикал с формула, в която R11 e Н, -OR6; R12 е Н, алкил; или R11 и R12 образуват оксорадикал. Изобретението се отнася и до солите и оптическите и геометрични изомери на посочените съединения.
BG103150A 1997-06-13 1999-02-05 Биароматни съединения и фармацевтични и козметични състави, които ги съдържат BG63501B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9707358A FR2764604B1 (fr) 1997-06-13 1997-06-13 Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant
PCT/FR1998/001238 WO1998056783A1 (fr) 1997-06-13 1998-06-12 Composes bi-aromatiques et compositions pharmaceutiques et cosmetiques les contenant

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BG103150A true BG103150A (bg) 1999-11-30
BG63501B1 BG63501B1 (bg) 2002-03-29

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US (3) US6103762A (bg)
EP (1) EP0977749B1 (bg)
JP (1) JP3665079B2 (bg)
KR (1) KR100443179B1 (bg)
CN (1) CN1310900C (bg)
AT (1) ATE214385T1 (bg)
AU (1) AU738779B2 (bg)
BG (1) BG63501B1 (bg)
BR (1) BR9805997A (bg)
CA (1) CA2263362C (bg)
CZ (1) CZ45599A3 (bg)
DE (1) DE69804205T2 (bg)
DK (1) DK0977749T3 (bg)
ES (1) ES2173594T3 (bg)
FR (1) FR2764604B1 (bg)
HU (1) HUP0001858A3 (bg)
IL (1) IL128336A0 (bg)
MX (1) MXPA99001455A (bg)
NO (1) NO990485L (bg)
NZ (1) NZ334033A (bg)
PL (1) PL332041A1 (bg)
PT (1) PT977749E (bg)
RU (1) RU2178787C2 (bg)
TR (1) TR199900302T1 (bg)
WO (1) WO1998056783A1 (bg)
YU (1) YU6699A (bg)

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FR2764604B1 (fr) 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
BR0213678A (pt) * 2001-10-31 2004-10-26 Hoffmann La Roche Compostos retinóides heterocìclicos
US7297712B2 (en) * 2002-03-27 2007-11-20 Council Of Scientific And Industrial Research Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment
AU2003242583A1 (en) * 2002-06-04 2003-12-19 Galderma Research & Development, S.N.C. Novel ligands that are inhibitors of the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics
EP1513803B1 (en) * 2002-06-04 2008-06-18 Galderma Research & Development Ligands that are inhibitors of the rar receptors
FR2840299B1 (fr) * 2002-06-04 2006-05-05 Galderma Res & Dev NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
FR2840300B1 (fr) * 2002-06-04 2004-07-16 Galderma Res & Dev NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
US9044408B2 (en) * 2011-10-31 2015-06-02 Avon Products, Inc. Cosmetic use of N-heteroarylbisamide analogs and related compounds
WO2021064072A1 (en) 2019-10-02 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of retinoic acid receptor (rar) agonists for reversing, preventing, or delaying calcification of aortic valve

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GB9203265D0 (en) 1992-02-15 1992-04-01 Fisons Plc Pharmaceutically active compound
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
GB9420557D0 (en) * 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
FR2746098B1 (fr) * 1996-03-14 1998-04-30 Composes propynyl biaromatiques
FR2764604B1 (fr) 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant

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CA2263362C (fr) 2007-09-18
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US6849658B2 (en) 2005-02-01
DK0977749T3 (da) 2002-06-10
DE69804205T2 (de) 2002-10-24
JP2002515068A (ja) 2002-05-21
EP0977749A1 (fr) 2000-02-09
PL332041A1 (en) 1999-08-16
DE69804205D1 (de) 2002-04-18
RU2178787C2 (ru) 2002-01-27
CZ45599A3 (cs) 1999-06-16
JP3665079B2 (ja) 2005-06-29
AU738779B2 (en) 2001-09-27
BG63501B1 (bg) 2002-03-29
US6103762A (en) 2000-08-15
HUP0001858A3 (en) 2002-01-28
KR20000068160A (ko) 2000-11-25
NO990485L (no) 1999-04-13
US20030216586A1 (en) 2003-11-20
CN1229407A (zh) 1999-09-22
AU8114398A (en) 1998-12-30
NO990485D0 (no) 1999-02-02
FR2764604A1 (fr) 1998-12-18
HUP0001858A2 (hu) 2000-10-28
YU6699A (sh) 2000-03-21
CA2263362A1 (fr) 1998-12-17
FR2764604B1 (fr) 1999-09-10
US6346546B1 (en) 2002-02-12
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KR100443179B1 (ko) 2004-08-04
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CN1310900C (zh) 2007-04-18
EP0977749B1 (fr) 2002-03-13
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WO1998056783A1 (fr) 1998-12-17

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