BE902626A - NEW DELAYED GALEINIC FORM. - Google Patents
NEW DELAYED GALEINIC FORM.Info
- Publication number
- BE902626A BE902626A BE1/011271A BE1011271A BE902626A BE 902626 A BE902626 A BE 902626A BE 1/011271 A BE1/011271 A BE 1/011271A BE 1011271 A BE1011271 A BE 1011271A BE 902626 A BE902626 A BE 902626A
- Authority
- BE
- Belgium
- Prior art keywords
- matrix
- galeinic
- water
- agent
- new delayed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention a pour objet une dispersion solide d'un agent ayant une activité pharmacologique, dans un matrice cristalline soluble dans l'eau servant d'excipient, caractérisée en ce que l'agent : a) a une solublilité maximale dans l'eau de 0,01% à 37 degrés C, b) est présent dans la matrice à une concentration supérieure à 5 % en poids, c) est présent dans la matrice à une concentration supérieure à 5 % en poids sous une forme cristalline cohérente. Structure secondaire d'un agent actif résultant de l'extraction de la matrice, par exemple avec de l'eau.The subject of the invention is a solid dispersion of an agent having pharmacological activity, in a water-soluble crystalline matrix serving as an excipient, characterized in that the agent: a) has maximum solubility in water 0.01% at 37 degrees C, b) is present in the matrix at a concentration greater than 5% by weight, c) is present in the matrix at a concentration greater than 5% by weight in a coherent crystalline form. Secondary structure of an active agent resulting from the extraction of the matrix, for example with water.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3422083 | 1984-06-14 | ||
DE3442566 | 1984-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE902626A true BE902626A (en) | 1985-12-10 |
Family
ID=25822108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE1/011271A BE902626A (en) | 1984-06-14 | 1985-06-10 | NEW DELAYED GALEINIC FORM. |
Country Status (21)
Country | Link |
---|---|
AT (1) | AT391806B (en) |
AU (2) | AU587190B2 (en) |
BE (1) | BE902626A (en) |
CA (1) | CA1264441A (en) |
CY (1) | CY1635A (en) |
DE (1) | DE3520184C2 (en) |
DK (1) | DK167649B1 (en) |
ES (1) | ES8702141A1 (en) |
FR (1) | FR2565822B1 (en) |
GB (3) | GB2160100B (en) |
GR (1) | GR851430B (en) |
HK (1) | HK25192A (en) |
HU (1) | HU198844B (en) |
IE (1) | IE58834B1 (en) |
IL (1) | IL75490A0 (en) |
IT (1) | IT1200080B (en) |
LU (1) | LU85946A1 (en) |
NL (1) | NL194389C (en) |
NZ (1) | NZ212390A (en) |
PT (1) | PT80635B (en) |
SE (1) | SE504583C2 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1187751B (en) * | 1985-10-15 | 1987-12-23 | Eurand Spa | PROCEDURE FOR THE PREPARATION OF SOLID FORMULATIONS OF NIFEDIPINE WITH HIGH BIO AVAILABILITY AND WITH PROLONGED EFFECT AND FORMULATIONS SO OBTAINED |
US4816263A (en) * | 1987-10-02 | 1989-03-28 | Alza Corporation | Dosage form for treating cardiovascular diseases comprising isradipine |
EP0406315B1 (en) * | 1988-03-24 | 1992-11-11 | Bukh Meditec A/S | Controlled release composition |
GR1000270B (en) * | 1988-09-30 | 1992-05-12 | Alza Corp | Dose for cardiovascular troubles therapy |
DK469989D0 (en) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | PHARMACEUTICAL PREPARATION |
MX9300110A (en) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | PHARMACEUTICAL PREPARATION IN THE FORM OF AN EFFERVESCENCE OR DISINTEGRATION TABLET OR OF AN INSTANT-TYPE GRANULATE AND PROCEDURE FOR ITS PREPARATION. |
DE4201179A1 (en) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Granulates or pellets comprising dispersion of active agent in hydrophilic macromolecules - are e.g. for treatment of depression, hypertension, rheumatism, etc. |
US6726930B1 (en) | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
GB2281697A (en) * | 1993-09-14 | 1995-03-15 | Euro Celtique Sa | Laxative compositions in capsules |
US6093420A (en) | 1996-07-08 | 2000-07-25 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
DE19710009A1 (en) * | 1997-03-12 | 1998-09-24 | Knoll Ag | Multi-phase preparation forms containing active ingredients |
US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6787157B1 (en) | 1998-03-10 | 2004-09-07 | Abbott Laboratories | Multiphase active ingredient-containing formulations |
WO2000076480A2 (en) * | 1999-06-11 | 2000-12-21 | Eli Lilly And Company | Pharmaceutical materials and methods for their preparation and use |
US7001892B1 (en) | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
ATE324909T1 (en) * | 1999-08-04 | 2006-06-15 | Astellas Pharma Inc | STABLE MEDICAL COMPOSITIONS FOR ORAL ADMINISTRATION USING IRON OXIDES |
JP3893058B2 (en) | 1999-09-30 | 2007-03-14 | ペンウェスト ファーマシューティカルズ カンパニー | Sustained release matrix system for highly soluble drugs |
EP1368006B1 (en) * | 2001-02-13 | 2006-05-03 | AstraZeneca AB | Novel modified released formulation |
US7135436B2 (en) | 2003-05-05 | 2006-11-14 | J.F. Daley International, Ltd. | Solid algicide, preparation and usage in recirculating water |
EP1690528A1 (en) | 2005-02-11 | 2006-08-16 | Abbott GmbH & Co. KG | Process for the preparation of dosage forms comprising a solid dispersion of a microcrystalline active agent |
US8399007B2 (en) | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
CA2670749A1 (en) | 2006-12-05 | 2008-06-12 | Landec Corporation | Drug delivery |
US8114883B2 (en) | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
CN102271661A (en) * | 2008-08-20 | 2011-12-07 | 德克萨斯州立大学董事会 | Hot-melt extrusion of modified release multi-particulates |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1617362A1 (en) * | 1967-11-17 | 1971-03-25 | Beiersdorf Ag | Process for the production of medicaments with delayed release of active substances in the form of capsules |
DE2400819C2 (en) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Process for the production of solid preparations of poorly soluble active pharmaceutical ingredients in extremely fine distribution |
DE2546577B2 (en) * | 1975-10-17 | 1981-04-02 | Sandoz-Patent-GmbH, 7850 Lörrach | Solid substances made from polyvinylpyrrolidone and ergot alkaloids |
GB1504553A (en) * | 1975-11-17 | 1978-03-22 | Sandoz Ltd | Tablet formulations |
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
DK149855C (en) * | 1977-06-20 | 1987-04-21 | Sandoz Ag | METHOD OF ANALOGY FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES |
CH639659A5 (en) * | 1978-12-18 | 1983-11-30 | Sandoz Ag | NEW 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE. |
EP0001247A1 (en) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Pharmaceutical preparation containing nifedipine and a method for producing the same. |
DK154607C (en) * | 1978-12-21 | 1989-06-05 | Sandoz Ag | PROCEDURE FOR PREPARING A PHARMACEUTICAL FORM FOR ORAL ADMINISTRATION OF ERGOTAL KALOIDS |
DE2904310A1 (en) * | 1979-02-05 | 1980-08-07 | Boehringer Mannheim Gmbh | MOLDINGS WITH RETARDED ACTIVE SUBSTANCE RELEASE AND METHOD FOR THE PRODUCTION THEREOF |
JPS56115726A (en) * | 1980-02-20 | 1981-09-11 | Kaken Pharmaceut Co Ltd | Pharmaceutical containing nifedipine |
DE3033919A1 (en) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | SOLID PHARMACEUTICAL PREPARATIONS CONTAINING NIFEDIPINE AND METHOD FOR THE PRODUCTION THEREOF |
US4442112A (en) * | 1981-09-02 | 1984-04-10 | Sandoz Ltd. | Dihydropyridine derivatives useful in treating vascular headaches |
EP0078430B2 (en) * | 1981-10-29 | 1993-02-10 | Bayer Ag | Process for preparing solid fast-releasing drug formulations of dihydropyridines |
CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
DE3318649A1 (en) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | TWO-PHASE FORMULATION |
-
1985
- 1985-05-31 HU HU852126A patent/HU198844B/en unknown
- 1985-05-31 NL NL8501578A patent/NL194389C/en not_active IP Right Cessation
- 1985-06-05 DE DE3520184A patent/DE3520184C2/en not_active Expired - Lifetime
- 1985-06-10 FR FR858508850A patent/FR2565822B1/en not_active Expired
- 1985-06-10 BE BE1/011271A patent/BE902626A/en not_active IP Right Cessation
- 1985-06-12 IE IE146085A patent/IE58834B1/en not_active IP Right Cessation
- 1985-06-12 CA CA000483768A patent/CA1264441A/en not_active Expired
- 1985-06-12 GB GB8514855A patent/GB2160100B/en not_active Expired
- 1985-06-12 DK DK264785A patent/DK167649B1/en not_active IP Right Cessation
- 1985-06-12 PT PT80635A patent/PT80635B/en unknown
- 1985-06-12 NZ NZ212390A patent/NZ212390A/en unknown
- 1985-06-12 AU AU43486/85A patent/AU587190B2/en not_active Ceased
- 1985-06-12 GR GR851430A patent/GR851430B/el unknown
- 1985-06-12 ES ES544075A patent/ES8702141A1/en not_active Expired
- 1985-06-12 IL IL75490A patent/IL75490A0/en not_active IP Right Cessation
- 1985-06-12 AT AT0174885A patent/AT391806B/en not_active IP Right Cessation
- 1985-06-13 IT IT8548210A patent/IT1200080B/en active
- 1985-06-13 LU LU85946A patent/LU85946A1/en unknown
- 1985-06-13 SE SE8502950A patent/SE504583C2/en not_active IP Right Cessation
-
1987
- 1987-11-19 GB GB8727056A patent/GB2196852B/en not_active Expired
- 1987-11-19 GB GB8727055A patent/GB2196851B/en not_active Expired
-
1989
- 1989-11-09 AU AU44543/89A patent/AU4454389A/en not_active Abandoned
-
1992
- 1992-04-02 HK HK251/92A patent/HK25192A/en not_active IP Right Cessation
- 1992-11-06 CY CY1635A patent/CY1635A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE20 | Patent expired |
Owner name: *NOVARTIS A.G. Effective date: 20050610 |
|
RE20 | Patent expired |
Owner name: *NOVARTIS A.G. Effective date: 20050610 |